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Literature summary extracted from

  • Ma, E.B.; He, Y.P.; Zhu, K.Y.
    Comparative studies of acetylcholinesterases purified from two field populations of the oriental migratory locust (Locusta migratoria manilensis): implications of insecticide resistance (2004), Pestic. Biochem. Physiol., 78, 67-77.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.7 BW284c51 0.001 mM, almost complete inhibition Locusta migratoria manilensis
3.1.1.7 chlorpyrifos oxon enzyme from Huanghua population is 62fold less sensitive than from Pingshan population Locusta migratoria manilensis
3.1.1.7 demeton-S-methyl enzyme from Huanghua population is 2fold less sensitive than from Pingshan population Locusta migratoria manilensis
3.1.1.7 eserine 0.001 mM, almost complete inhibition Locusta migratoria manilensis
3.1.1.7 ethopropazine about 5% inhibition at 0.001 mM Locusta migratoria manilensis
3.1.1.7 paraoxon enzyme from Huanghua population is 1.6fold less sensitive than from Pingshan population Locusta migratoria manilensis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.1.7 0.012
-
 butyrylthiocholine pH 7.5, 24°C, Huanghua population Locusta migratoria manilensis
3.1.1.7 0.026
-
 butyrylthiocholine pH 7.5, 24°C, Pingshan population Locusta migratoria manilensis
3.1.1.7 0.043
-
 acetylthiocholine pH 7.5, 24°C, Pingshan population Locusta migratoria manilensis
3.1.1.7 0.044
-
 acetylthiocholine pH 7.5, 24°C, Huanghua population Locusta migratoria manilensis

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.7 Locusta migratoria manilensis
-
 collected from Huanghua and Pingshan County
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.7 purification factor and yield are significantly lower in Huanghua population than in Pingshan population Locusta migratoria manilensis

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.7 abdomen
-
 Locusta migratoria manilensis
-
3.1.1.7 femur
-
 Locusta migratoria manilensis
-
3.1.1.7 head
-
 Locusta migratoria manilensis
-
3.1.1.7 thorax
-
 Locusta migratoria manilensis
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.1.7 0.00066
-
 24°C, pH 7.5, Pingshan population, female, thorax Locusta migratoria manilensis
3.1.1.7 0.00078
-
 24°C, pH 7.5, Pingshan population, female, abdomen Locusta migratoria manilensis
3.1.1.7 0.00082
-
 24°C, pH 7.5, Pingshan population, female, femur Locusta migratoria manilensis
3.1.1.7 0.00104
-
 24°C, pH 7.5, Pingshan population, male, abdomen Locusta migratoria manilensis
3.1.1.7 0.0011
-
 24°C, pH 7.5, Pingshan population, male, thorax Locusta migratoria manilensis
3.1.1.7 0.00122
-
 24°C, pH 7.5, Pingshan population, male, femur Locusta migratoria manilensis
3.1.1.7 0.0022
-
 24°C, pH 7.5, Pingshan population, female, head Locusta migratoria manilensis
3.1.1.7 0.0038
-
 24°C, pH 7.5, Pingshan population, male, head Locusta migratoria manilensis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.7 acetylthiocholine + H2O
-
 Locusta migratoria manilensis thiocholine + acetate
-
 ?
3.1.1.7 butyrylthiocholine + H2O
-
 Locusta migratoria manilensis thiocholine + butanoate
-
 ?