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Literature summary extracted from

  • Frederickson, M.; Roszak, A.W.; Coggins, J.R.; Lapthorn, A.J.; Abell, C.
    (1R,4S,5R)-3-Fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid: the fluoro analogue of the enolate intermediate in the reaction catalyzed by type II dehydroquinases (2004), Org. Biomol. Chem., 2, 1592-1596.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.10 (1R,4S,5R)-3,3-difluoro-1,4,5-trihydroxycyclohexane-1-carboxylic acid inhibitor is selective for the type II dehydroquinase over the type I dehydroquinase Mycobacterium tuberculosis
4.2.1.10 (1R,4S,5R)-3,3-difluoro-1,4,5-trihydroxycyclohexane-1-carboxylic acid
-
 Salmonella enterica subsp. enterica serovar Typhi
4.2.1.10 (1R,4S,5R)-3,3-difluoro-1,4,5-trihydroxycyclohexane-1-carboxylic acid inhibitor is selective for the type II dehydroquinase over the type I dehydroquinase Streptomyces coelicolor
4.2.1.10 (1R,4S,5R)-3-fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid inhibitor is selective for the type II dehydroquinase over the type I dehydroquinase Mycobacterium tuberculosis
4.2.1.10 (1R,4S,5R)-3-fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid
-
 Salmonella enterica subsp. enterica serovar Typhi
4.2.1.10 (1R,4S,5R)-3-fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid inhibitor is selective for the type II dehydroquinase over the type I dehydroquinase Streptomyces coelicolor

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.10 Mycobacterium tuberculosis P9WPX7
-
-
4.2.1.10 Mycobacterium tuberculosis H37Rv P9WPX7
-
-
4.2.1.10 Salmonella enterica subsp. enterica serovar Typhi
-
-
-
4.2.1.10 Streptomyces coelicolor P15474
-
-

Synonyms

EC Number Synonyms Comment Organism
4.2.1.10 Type I dehydroquinase
-
 Salmonella enterica subsp. enterica serovar Typhi
4.2.1.10 Type II dehydroquinase
-
 Mycobacterium tuberculosis
4.2.1.10 Type II dehydroquinase
-
 Streptomyces coelicolor

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.2.1.10 0.01
-
 (1R,4S,5R)-3-fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid
-
 Mycobacterium tuberculosis
4.2.1.10 0.015
-
 (1R,4S,5R)-3-fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid
-
 Streptomyces coelicolor
4.2.1.10 0.7
-
 (1R,4S,5R)-3,3-difluoro-1,4,5-trihydroxycyclohexane-1-carboxylic acid
-
 Mycobacterium tuberculosis
4.2.1.10 0.7
-
 (1R,4S,5R)-3,3-difluoro-1,4,5-trihydroxycyclohexane-1-carboxylic acid
-
 Streptomyces coelicolor
4.2.1.10 1.5
-
 (1R,4S,5R)-3-fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid
-
 Salmonella enterica subsp. enterica serovar Typhi
4.2.1.10 8
-
 (1R,4S,5R)-3,3-difluoro-1,4,5-trihydroxycyclohexane-1-carboxylic acid
-
 Salmonella enterica subsp. enterica serovar Typhi