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Literature summary extracted from

  • Rinner, O.; Makhankov, Y.V.; Biehlmaier, O.; Neuhauss, S.C.F.
    Knockdown of cone-specific kinase GRK7 in larval zebrafish leads to impaired cone response recovery and delayed dark adaptation (2005), Neuron, 47, 231-242.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.14 light
-
 Danio rerio

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.14 gene grk7a, DNA and amino acid sequence determination and analysis Danio rerio
2.7.11.14 gene grk7b, DNA and amino acid sequence determination and analysis Danio rerio

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.14 additional information construction of grk7a-knockout fish mutants, mutant larvae are delayed in electroretinographic measurements and temporal contrast sensitivity is reduced compared to the wild-type, overview Danio rerio

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.14 membrane
-
 Danio rerio 16020
-
2.7.11.14 photoreceptor outer segment
-
 Danio rerio 1750
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.14 ATP + cone opsin Danio rerio light-dependent phosphorylation ADP + phosphorylated cone opsin
-
 ?
2.7.11.14 additional information Danio rerio cone-specific kinase GRK7 is essential for cone vision ?
-
 ?
2.7.11.14 additional information Danio rerio for cone vision GRK1 is not essential ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.14 Danio rerio
-
 i.e. Brachydanio rerio, zebrafish
-
2.7.11.14 Danio rerio Q49HM8 gene grk7b; i.e. Brachydanio rerio, zebrafish
-
2.7.11.14 Danio rerio Q49HM9 gene grk7a; i.e. Brachydanio rerio, zebrafish
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.14 larva
-
 Danio rerio
-
2.7.11.14 photoreceptor
-
 Danio rerio
-
2.7.11.14 retinal cone outer segment Danio rerio
-
2.7.11.14 retinal cone outer segment GRK1-homologue GRK7a Danio rerio
-
2.7.11.14 retinal cone outer segment GRK1-homologue GRK7b Danio rerio
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.14 ATP + cone opsin light-dependent phosphorylation Danio rerio ADP + phosphorylated cone opsin
-
 ?
2.7.11.14 additional information cone-specific kinase GRK7 is essential for cone vision Danio rerio ?
-
 ?
2.7.11.14 additional information for cone vision GRK1 is not essential Danio rerio ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.14 cone-specific kinase GRK7
-
 Danio rerio
2.7.11.14 G-protein coupled protein kinase 7a
-
 Danio rerio
2.7.11.14 G-protein coupled protein kinase 7b
-
 Danio rerio
2.7.11.14 GRK1
-
 Danio rerio

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.14 ATP
-
 Danio rerio