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Literature summary extracted from

  • Zhen, X.; Goswami, S.; Abdali, S.A.; Gil, M.; Bakshi, K.; Friedman, E.
    Regulation of cyclin-dependent kinase 5 and calcium/calmodulin-dependent protein kinase II by phosphatidylinositol-linked dopamine receptor in rat brain (2004), Mol. Pharmacol., 66, 1500-1507.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.17 Calmodulin dependent on Rattus norvegicus
2.7.11.17 additional information 6-chloro-7,8-dihydroxy-3-methyl-1-(3-methyl-phenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine, i.e. SKF83959, induces transactivation of CaMK II via the brain phosphatidylinositol-linked dopamine receptor, which is inhibited by SCH23390 or U-73122 Rattus norvegicus
2.7.11.22 additional information 6-chloro-7,8-dihydroxy-3-methyl-1-(3-methyl-phenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine, i.e. SKF83959, induces transctivation of cdk5 via the brain phosphatidylinositol-linked dopamine receptor, which is inhibited by SCH23390 or U-73122 Rattus norvegicus
2.7.11.22 p35 regulatory activating cofactor of cdk5 Rattus norvegicus
2.7.11.22 p39 regulatory activating cofactor of cdk5 Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.17 2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)amino-N-(4-chlorocinnamyl)-N-methylbenzylamine i.e. KN-93 Rattus norvegicus
2.7.11.17 additional information R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, i.e. SCH23390, or the PLCbeta antagonist 1-[6-([17beta-methoxyestra-1,3,5(10)-trien-17-yl]amino)hexyl]-1H-pyrrole-2,5-dione, i.e. U-73122, inhibit CaMK II transactivation by SKF83959 via the brain phosphatidylinositol-linked dopamine receptor, the transactivation is attenuated by calphostin C or by intracellular calcium chelator BAPTA Rattus norvegicus
2.7.11.22 additional information R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, i.e. SCH23390, or the PLCbeta antagonist 1-[6-([17beta-methoxyestra-1,3,5(10)-trien-17-yl]amino)hexyl]-1H-pyrrole-2,5-dione, i.e. U-73122, inhibit cdk5 transactivation by SKF83959 via the brain phosphatidylinositol-linked dopamin receptor, the transactivation is attenuated by calphostin C or by intracellular calcium chelator BAPTA Rattus norvegicus
2.7.11.22 roscovitine
-
 Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.17 Ca2+ dependent on Rattus norvegicus
2.7.11.17 Mg2+
-
 Rattus norvegicus
2.7.11.22 Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.17 ATP + cAMP response element-binding protein Rattus norvegicus i.e. CREB, phosphorylation by CaMK II at Ser133 ADP + phosphorylated cAMP response element-binding protein
-
 ?
2.7.11.17 additional information Rattus norvegicus the phosphatidylinositol-linked dopamine receptor is involved in regulation of CaMK II enzyme activity in the brain ?
-
 ?
2.7.11.22 ATP + dopamine Rattus norvegicus phosphorylation by cdk5 ADP + phosphorylated dopamine
-
 ?
2.7.11.22 ATP + dopamine and cAMP-regulated phosphoprotein Rattus norvegicus i.e. DARPP-32, phosphorylation by cdk5 at Thr75 and Thr34 ADP + phosphorylated dopamine and cAMP-regulated phosphoprotein
-
 ?
2.7.11.22 additional information Rattus norvegicus the phosphatidylinositol-linked dopamine receptor is involved in regulation of cdk5 enzyme activity in the brain ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.17 Rattus norvegicus
-
-
-
2.7.11.22 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.17 brain frontal cortex Rattus norvegicus
-
2.7.11.22 brain frontal cortex Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.11.17 additional information
-
-
 Rattus norvegicus
2.7.11.22 additional information
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.17 ATP + cAMP response element-binding protein i.e. CREB, phosphorylation by CaMK II at Ser133 Rattus norvegicus ADP + phosphorylated cAMP response element-binding protein
-
 ?
2.7.11.17 additional information the phosphatidylinositol-linked dopamine receptor is involved in regulation of CaMK II enzyme activity in the brain Rattus norvegicus ?
-
 ?
2.7.11.22 ATP + dopamine phosphorylation by cdk5 Rattus norvegicus ADP + phosphorylated dopamine
-
 ?
2.7.11.22 ATP + dopamine and cAMP-regulated phosphoprotein i.e. DARPP-32, phosphorylation by cdk5 at Thr75 and Thr34 Rattus norvegicus ADP + phosphorylated dopamine and cAMP-regulated phosphoprotein
-
 ?
2.7.11.22 additional information the phosphatidylinositol-linked dopamine receptor is involved in regulation of cdk5 enzyme activity in the brain Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.17 calcium/calmodulin-dependent protein kinase II
-
 Rattus norvegicus
2.7.11.17 CaMK II
-
 Rattus norvegicus
2.7.11.22 Cdk5
-
 Rattus norvegicus
2.7.11.22 cyclin-dependent kinase 5
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.22 30
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.22 7.4
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.17 ATP
-
 Rattus norvegicus
2.7.11.22 ATP
-
 Rattus norvegicus