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Literature summary extracted from

  • Minchenko, O.H.; Ogura, T.; Opentanova, I.L.; Minchenko, D.O.; Esumi, H.
    Splice isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4: expression and hypoxic regulation (2005), Mol. Cell. Biochem., 280, 227-234.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.46 gene PFKFB4, DNA and amino acid sequence determination, expression analysis in DB-1 melanoma cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.46 dimethyloxalylglycine inhibits the splice isozyme PFKFB-4 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O Homo sapiens the enzyme is responsible for regulation of intracellular beta-D-fructose 2,6-bisphosphate level, which is a major allosteric activator of 6-phosphofructo 1-kinase, a key regulatory enzyme in glycolysis, the minor splice isozyme PFKFB-4 is responsible for hypoxia and dimethyloxalylglycine inhibition D-fructose 6-phosphate + phosphate
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?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.46 Homo sapiens Q16877 PFKFB4 gene, promoter region, and 5' untranslated region, partial sequence; minor splice isozyme PFKFB-4, major isozyme PFKFB-3
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.46 DB-1 cell melanoma cell line, minor splice isozyme PFKFB-4, major isozyme is PFKFB-3, isozyme PFKFB-4 is overexpressed in hypoxic conditions Homo sapiens
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3.1.3.46 melanoma cell minor splice isozyme PFKFB-4, major isozyme is PFKFB-3 Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O the enzyme is responsible for regulation of intracellular beta-D-fructose 2,6-bisphosphate level, which is a major allosteric activator of 6-phosphofructo 1-kinase, a key regulatory enzyme in glycolysis, the minor splice isozyme PFKFB-4 is responsible for hypoxia and dimethyloxalylglycine inhibition Homo sapiens D-fructose 6-phosphate + phosphate
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.46 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
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Homo sapiens
3.1.3.46 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4
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Homo sapiens
3.1.3.46 More bifunctional enzyme, cf. EC 2.7.1.105 Homo sapiens
3.1.3.46 PFKFB
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Homo sapiens