Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Kong, J.Y.; Klassen, S.S.; Rabkin, S.W.
    Ceramide activates a mitochondrial p38 mitogen-activated protein kinase: a potential mechanism for loss of mitochondrial transmembrane potential and apoptosis (2005), Mol. Cell. Biochem., 278, 39-51.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.24 additional information p38 MAPK is activated by phosphorylation Gallus gallus
2.7.11.24 N-acetylsphingosine i.e. C2-ceramide, an intracellular mediator of apoptosis, cell-permeable N-acetylsphingosine activates mitochondrial p38 MAPK Gallus gallus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.24 additional information no inhibition by PD98059 Gallus gallus
2.7.11.24 SB202190 specific p38 MAPK inhibitor Gallus gallus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.24 cytosol p38 MAPK Gallus gallus 5829
-
2.7.11.24 mitochondrion p38 MAPK Gallus gallus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.24 additional information Gallus gallus ceramide activation of mitochondrial p38 mitogen-activated protein kinase is a potential mechanism for loss of mitochondrial transmembrane potential and apoptosis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.24 Gallus gallus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.24 phosphoprotein p38 MAPK is activated by phosphorylation Gallus gallus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.24 cardiac myocyte
-
 Gallus gallus
-
2.7.11.24 embryo ventricular cells Gallus gallus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.24 additional information ceramide activation of mitochondrial p38 mitogen-activated protein kinase is a potential mechanism for loss of mitochondrial transmembrane potential and apoptosis Gallus gallus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.24 p38 MAPK
-
 Gallus gallus