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Literature summary extracted from

  • Makris, G.; Wright, J.D.; Ingham, E.; Holland, K.T.
    The hyaluronate lyase of Staphylococcus aureus - a virulence factor? (2004), Microbiology, 150, 2005-2013.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.2.1 complementation of an enzyme-deficient mutant strain by expression of hysA Staphylococcus aureus

Protein Variants

EC Number Protein Variants Comment Organism
4.2.2.1 additional information inactivation of gene hysA by insertion of ermC, encoding the erythromycin determinant, from plasmid pE194 resulting in mutant strains HL-6, HL-13T, and HL-16T, determination of virulence and pathogenicity of wild-type strain 8325-4, and mutant strains HL-6, HL-13T, and HL-16T, WA250, deficient in regulator agr, and PC1839, deficient in regulator sar, in mice, overview Staphylococcus aureus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.2.1 hyaluronic acid Staphylococcus aureus degradation of hyaluronate in connective tissue of hosts to facilitate invasion by subcutaneous infection, the enzyme is an essential bacterial virulence factor hyaluronic acid oligomers
-
 ?
4.2.2.1 hyaluronic acid Staphylococcus aureus NCTC 8325 degradation of hyaluronate in connective tissue of hosts to facilitate invasion by subcutaneous infection, the enzyme is an essential bacterial virulence factor hyaluronic acid oligomers
-
 ?
4.2.2.1 additional information Staphylococcus aureus global regulators sar and agr are involved in enzyme regulation ?
-
 ?
4.2.2.1 additional information Staphylococcus aureus NCTC 8325 global regulators sar and agr are involved in enzyme regulation ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.2.1 Staphylococcus aureus
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 strain 8325-4, gene hysA
-
4.2.2.1 Staphylococcus aureus NCTC 8325
-
 strain 8325-4, gene hysA
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.2.1 additional information wild-type enzyme expression is maximal during mid-exponential growth phase Staphylococcus aureus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.2.1 hyaluronic acid degradation Staphylococcus aureus hyaluronic acid oligomers
-
 ?
4.2.2.1 hyaluronic acid degradation of hyaluronate in connective tissue of hosts to facilitate invasion by subcutaneous infection, the enzyme is an essential bacterial virulence factor Staphylococcus aureus hyaluronic acid oligomers
-
 ?
4.2.2.1 hyaluronic acid degradation Staphylococcus aureus NCTC 8325 hyaluronic acid oligomers
-
 ?
4.2.2.1 hyaluronic acid degradation of hyaluronate in connective tissue of hosts to facilitate invasion by subcutaneous infection, the enzyme is an essential bacterial virulence factor Staphylococcus aureus NCTC 8325 hyaluronic acid oligomers
-
 ?
4.2.2.1 additional information global regulators sar and agr are involved in enzyme regulation Staphylococcus aureus ?
-
 ?
4.2.2.1 additional information global regulators sar and agr are involved in enzyme regulation Staphylococcus aureus NCTC 8325 ?
-
 ?