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Literature summary extracted from

  • Pasquare, S.J.; Salvador, G.A.; Giusto, N.M.
    Phospholipase D and phosphatidate phosphohydrolase activities in rat cerebellum during aging (2004), Lipids, 39, 553-560.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.4 NEM isozyme PAP1 is sensitive to NEM, while isozyme PAP2 is not Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.4 cytosol isozyme PAP2 Rattus norvegicus 5829
-
3.1.3.4 microsome PAP1 Rattus norvegicus
-
-
3.1.3.4 additional information isozyme PAP1 is located in all subcellular compartments, alterations in isozymes content in different subcellular compartments during aging, comparison of subcellular distribution in adult and aged rat cerebellum, overview Rattus norvegicus
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-
3.1.4.4 additional information enzyme activity is identical in adult and aged nuclear fraction, increases by 25% from adult to aged cerebellum in mitochondrial-synaptosomal fraction, decreases by 18% from adult to aged cerebellum in the microsomal fraction and increases by 14% from adult to aged cerebellum in cytosolic fraction Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.4 Mg2+ isozyme PAP1 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.4 additional information Rattus norvegicus the enzyme activity is involved in generation of phosphatidic acid and diaclyglycerol implicated in signal transduction, and in aging, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.4 Rattus norvegicus
-
-
-
3.1.4.4 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.4 cerebellum isozyme PAP1 in all subcellular fractions, isozyme PAP2 in cytosol Rattus norvegicus
-
3.1.4.4 cerebellum development of phospholipase D activity during ageing. Enzyme activity is identical in adult and aged nuclear fraction, increases by 25% from adult to aged cerebellum in mitochondrial-synaptosomal fraction, decreases by 18% from adult to aged cerebellum in the microsomal fraction and increases by 14% from adult to aged cerebellum in cytosolic fraction Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.4 additional information the enzyme activity is involved in generation of phosphatidic acid and diaclyglycerol implicated in signal transduction, and in aging, overview Rattus norvegicus ?
-
 ?
3.1.4.4 phosphatidylcholine + H2O
-
 Rattus norvegicus 1,2-diacylglycerophosphate + choline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.4 PAP
-
 Rattus norvegicus
3.1.3.4 phosphatidate phosphohydrolase
-
 Rattus norvegicus
3.1.4.4 PIP2-PLD
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.3.4 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.3.4 6.5
-
 assay at Rattus norvegicus