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Literature summary extracted from

  • Shleper, M.; Kartvelishvily, E.; Wolosker, H.
    D-Serine is the dominant endogenous coagonist for NMDA receptor neurotoxicity in organotypic hippocampal slices (2005), J. Neurosci., 25, 9413-9417.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
4.3.1.18 degradation the enzyme is applied to remove endogenous D-serine from organotypic hippocampal slices. Complete removal of D-serine virtually abolishes NMDA-elicited neurotoxicity Escherichia coli

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.3.1.18 expression in Escherichia coli Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.3.1.18 0.1
-
 D-serine
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.3.1.18 D-serine Escherichia coli
-
 pyruvate + NH3
-
 ?
4.3.1.18 D-serine Escherichia coli CFT073
-
 pyruvate + NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.3.1.18 Escherichia coli
-
 recombinant enzyme
-
4.3.1.18 Escherichia coli CFT073
-
 recombinant enzyme
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.3.1.18 to homogeneity Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.3.1.18 D-serine
-
 Escherichia coli pyruvate + NH3
-
 ?
4.3.1.18 D-serine
-
 Escherichia coli CFT073 pyruvate + NH3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.3.1.18 D-Serine deaminase
-
 Escherichia coli
4.3.1.18 DsdA
-
 Escherichia coli

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.3.1.18 15.7
-
 D-serine
-
 Escherichia coli