EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.17 | Calmodulin | dependent on, Ca2+/calmodulin-dependent, reversible enzyme clustering by self-association of the recombinant CaMKII, which might be hindered by autophosphorylation at Thr286, mechanism, overview | Rattus norvegicus | |
2.7.11.17 | ionomycin | - |
Rattus norvegicus |
EC Number | Cloned (Comment) | Organism |
---|---|---|
2.7.11.17 | expression of GFP-tagged wild-type and mutant CaMKII in neuronal cultures and in HEK-293 cells, pH-dependent, Ca2+/calmodulin-dependent, reversible enzyme clustering by self-association of the recombinant CaMKII, which might be hindered by autophosphorylation at Thr286, mechanism, overview | Rattus norvegicus |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.7.11.17 | I205K | site-directed mutagenesis, the mutant CaMKII does not undergo self-association in recombinant HEK-293 cells | Rattus norvegicus |
2.7.11.17 | T286D | site-directed mutagenesis, the mutant CaMKII exhibits poor self-association in recombinant HEK-293 cells and is impaired in autophosphorylation | Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.7.11.17 | endoplasmic reticulum | perinuclear, a nonsynaptic site | Rattus norvegicus | 5783 | - |
2.7.11.17 | additional information | glutamate receptor stimulation induces Ca2+-dependent CaMKII translocation to synaptic and nonsynaptic sites | Rattus norvegicus | - |
- |
2.7.11.17 | perinuclear space | endoplasmic reticulum | Rattus norvegicus | - |
- |
2.7.11.17 | synapse | - |
Rattus norvegicus | 45202 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.17 | Ca2+ | dependent on, Ca2+/calmodulin-dependent, reversible enzyme clustering by self-association of the recombinant CaMKII, which might be hindered by autophosphorylation at Thr286, mechanism, overview | Rattus norvegicus | |
2.7.11.17 | Mg2+ | - |
Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.17 | additional information | Rattus norvegicus | glutamate receptor stimulation induces Ca2+-dependent CaMKII translocation to synaptic and nonsynaptic sites | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.11.17 | Rattus norvegicus | - |
isozyme CaMKIIalpha | - |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
2.7.11.17 | phosphoprotein | CaMKII is autophosphorylated at Thr286 | Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.11.17 | brain | - |
Rattus norvegicus | - |
2.7.11.17 | hippocampus | - |
Rattus norvegicus | - |
2.7.11.17 | neuron | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.17 | additional information | glutamate receptor stimulation induces Ca2+-dependent CaMKII translocation to synaptic and nonsynaptic sites | Rattus norvegicus | ? | - |
? | |
2.7.11.17 | additional information | CaMKII performs autophosphorylation at Thr286 | Rattus norvegicus | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.11.17 | alphaCaMKII | - |
Rattus norvegicus |
2.7.11.17 | Ca2+/calmodulin-dependent protein kinase II | - |
Rattus norvegicus |
2.7.11.17 | CaMKII | - |
Rattus norvegicus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.17 | ATP | - |
Rattus norvegicus |