EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.17 | Calmodulin | dependent on | Mus musculus | |
2.7.11.17 | Calmodulin | dependent on | Rattus norvegicus | |
2.7.11.17 | additional information | activating phosphorylation by calmodulin-dependent kinase kinase is required for CaMKI function in long-term potentiation, and learning and memory | Mus musculus | |
2.7.11.17 | additional information | activating phosphorylation by calmodulin-dependent kinase kinase is required for CaMKI function in long-term potentiation, and learning and memory | Rattus norvegicus |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.17 | Ca2+ | has a regulatory function for CaMKI activity | Mus musculus | |
2.7.11.17 | Ca2+ | has a regulatory function for CaMKI activity | Rattus norvegicus | |
2.7.11.17 | Mg2+ | - |
Mus musculus | |
2.7.11.17 | Mg2+ | - |
Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.17 | additional information | Mus musculus | calmodulin-dependent kinase kinase/calmodulin kinase I activity, not CaMKIV or CaMKII, gates extracellular-signal-regulated kinase-dependent long-term potentiation required for learning and memory, Ras-GRF1 and ERK are also involved, NMDA-dependent activation of ERK, CaMKK pathway regulation, overview | ? | - |
? | |
2.7.11.17 | additional information | Rattus norvegicus | calmodulin-dependent kinase kinase/calmodulin kinase I activity, not CaMKIV or CaMKII, gates extracellular-signal-regulated kinase-dependent long-term potentiation required for learning and memory, Ras-GRF1 and ERK are also involved, NMDA-dependent activation of ERK, CaMKK pathway regulation, overview | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.11.17 | Mus musculus | - |
male C57BL/6 mice | - |
2.7.11.17 | Rattus norvegicus | - |
Sprague-Dawley rats | - |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
2.7.11.17 | phosphoprotein | activating phosphorylation by calmodulin-dependent kinase kinase is required for CaMKI function in long-term potentiation, and learning and memory | Mus musculus |
2.7.11.17 | phosphoprotein | activating phosphorylation by calmodulin-dependent kinase kinase is required for CaMKI function in long-term potentiation, and learning and memory | Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.11.17 | brain | - |
Mus musculus | - |
2.7.11.17 | brain | - |
Rattus norvegicus | - |
2.7.11.17 | hippocampus | neurons | Mus musculus | - |
2.7.11.17 | hippocampus | neurons | Rattus norvegicus | - |
2.7.11.17 | neuron | - |
Mus musculus | - |
2.7.11.17 | neuron | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.17 | additional information | calmodulin-dependent kinase kinase/calmodulin kinase I activity, not CaMKIV or CaMKII, gates extracellular-signal-regulated kinase-dependent long-term potentiation required for learning and memory, Ras-GRF1 and ERK are also involved, NMDA-dependent activation of ERK, CaMKK pathway regulation, overview | Mus musculus | ? | - |
? | |
2.7.11.17 | additional information | calmodulin-dependent kinase kinase/calmodulin kinase I activity, not CaMKIV or CaMKII, gates extracellular-signal-regulated kinase-dependent long-term potentiation required for learning and memory, Ras-GRF1 and ERK are also involved, NMDA-dependent activation of ERK, CaMKK pathway regulation, overview | Rattus norvegicus | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.11.17 | calmodulin kinase I | - |
Mus musculus |
2.7.11.17 | calmodulin kinase I | - |
Rattus norvegicus |
2.7.11.17 | CaMKI | - |
Mus musculus |
2.7.11.17 | CaMKI | - |
Rattus norvegicus |
2.7.11.17 | CaMKII | - |
Mus musculus |
2.7.11.17 | CaMKII | - |
Rattus norvegicus |
2.7.11.17 | CaMKIV | - |
Mus musculus |
2.7.11.17 | CaMKIV | - |
Rattus norvegicus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.17 | ATP | - |
Mus musculus | |
2.7.11.17 | ATP | - |
Rattus norvegicus |