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Literature summary extracted from

  • Mehren, J.E.; Griffith, L.C.
    Calcium-independent calcium/calmodulin-dependent protein kinase II in the adult Drosophila CNS enhances the training of pheromonal cues (2004), J. Neurosci., 24, 10584-10593.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.17 Calmodulin the unphosphorylated CaMK1 is dependent on Ca2+ and calmodulin, while the autophosphorylated enzyme is not Drosophila melanogaster

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.17 T287D site-directed mutagenesis, the Ca2+-independent mutant expression leads to reduced viability of flies, the toxic effect can be rescued by tetracycline, expression of the mutant in brain mushroom bodies does not affect the immediate memory, overview Drosophila melanogaster

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.17 Ca2+ the unphosphorylated CaMK1 is dependent on Ca2+ and calmodulin, while the autophosphorylated enzyme is not Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.17 additional information Drosophila melanogaster CaMKII is crucial for cellular and behavioral plasticity, autophosphorylation renders the enzyme independent on Ca2+ and calmodulin, which allows it to act as a molecular memory switch, CaMKII is required for memory formation of the brain in specific neurons, Ca2+-independent CaMKII mutant T287D in the adult Drosophila melanogaster CNS enhances plasticity and the training of pheromonal cues, mechanism, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.17 Drosophila melanogaster
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.17 phosphoprotein the enzyme performs Ca2+/calmodulin-dependent autophosphorylation, which renders the enzyme independent on Ca2+ and calmodulin Drosophila melanogaster

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.17 brain
-
 Drosophila melanogaster
-
2.7.11.17 central nervous system
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.17 additional information CaMKII is crucial for cellular and behavioral plasticity, autophosphorylation renders the enzyme independent on Ca2+ and calmodulin, which allows it to act as a molecular memory switch, CaMKII is required for memory formation of the brain in specific neurons, Ca2+-independent CaMKII mutant T287D in the adult Drosophila melanogaster CNS enhances plasticity and the training of pheromonal cues, mechanism, overview Drosophila melanogaster ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.17 calcium-independent calcium/calmodulin-dependent protein kinase II
-
 Drosophila melanogaster
2.7.11.17 calcium/calmodulin-dependent protein kinase II
-
 Drosophila melanogaster
2.7.11.17 CaMKII
-
 Drosophila melanogaster

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.17 ATP
-
 Drosophila melanogaster