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Literature summary extracted from

  • Zhu, X.; Brown, B.; Li, A.; Mears, A.J.; Swaroop, A.; Craft, C.M.
    GRK1-dependent phosphorylation of S and M opsins and their binding to cone arrestin during cone phototransduction in the mouse retina (2003), J. Neurosci., 23, 6152-6160.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.14 light
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.14 additional information GRK1-dependent phosphorylation of cone opsins and binding to cone arrestin leads to association of cone arrestins to the membrane in a light-dependent manner Mus musculus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.14 ATP + M opsin Mus musculus M opsin binds to cone arrestin during cone phototransduction in the retina ADP + phosphorylated m opsin
-
 ?
2.7.11.14 ATP + M opsin Mus musculus C57/BL6J M opsin binds to cone arrestin during cone phototransduction in the retina ADP + phosphorylated m opsin
-
 ?
2.7.11.14 ATP + S opsin Mus musculus S opsin binds to cone arrestin during cone phototransduction in the retina ADP + phosphorylated S opsin
-
 ?
2.7.11.14 ATP + S opsin Mus musculus C57/BL6J S opsin binds to cone arrestin during cone phototransduction in the retina ADP + phosphorylated S opsin
-
 ?
2.7.11.14 additional information Mus musculus analysis of the deactivation of the cone phototransduction cascade in mouse retina and the role of GRK1, GRK1-dependent phosphorylation of cone opsins and binding to cone arrestin leads to association of cone arrestins to the membrane in a light-dependent manner ?
-
 ?
2.7.11.14 additional information Mus musculus C57/BL6J analysis of the deactivation of the cone phototransduction cascade in mouse retina and the role of GRK1, GRK1-dependent phosphorylation of cone opsins and binding to cone arrestin leads to association of cone arrestins to the membrane in a light-dependent manner ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.14 Mus musculus
-
 C57BL/6J mice
-
2.7.11.14 Mus musculus C57/BL6J
-
 C57BL/6J mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.14 photoreceptor S and M cone photoreceptors, expression of GRK1 Mus musculus
-
2.7.11.14 retina
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.14 ATP + M cone opsin light-dependent, multi-site phosphorylation Mus musculus ADP + phosphorylated M cone opsin
-
 ?
2.7.11.14 ATP + M cone opsin light-dependent, multi-site phosphorylation Mus musculus C57/BL6J ADP + phosphorylated M cone opsin
-
 ?
2.7.11.14 ATP + M opsin M opsin binds to cone arrestin during cone phototransduction in the retina Mus musculus ADP + phosphorylated m opsin
-
 ?
2.7.11.14 ATP + M opsin M opsin binds to cone arrestin during cone phototransduction in the retina Mus musculus C57/BL6J ADP + phosphorylated m opsin
-
 ?
2.7.11.14 ATP + S cone opsin light-dependent, multi-site phosphorylation Mus musculus ADP + phosphorylated S cone opsin
-
 ?
2.7.11.14 ATP + S cone opsin light-dependent, multi-site phosphorylation Mus musculus C57/BL6J ADP + phosphorylated S cone opsin
-
 ?
2.7.11.14 ATP + S opsin S opsin binds to cone arrestin during cone phototransduction in the retina Mus musculus ADP + phosphorylated S opsin
-
 ?
2.7.11.14 ATP + S opsin S opsin binds to cone arrestin during cone phototransduction in the retina Mus musculus C57/BL6J ADP + phosphorylated S opsin
-
 ?
2.7.11.14 additional information analysis of the deactivation of the cone phototransduction cascade in mouse retina and the role of GRK1, GRK1-dependent phosphorylation of cone opsins and binding to cone arrestin leads to association of cone arrestins to the membrane in a light-dependent manner Mus musculus ?
-
 ?
2.7.11.14 additional information analysis of the deactivation of the cone phototransduction cascade in mouse retina and the role of GRK1, GRK1-dependent phosphorylation of cone opsins and binding to cone arrestin leads to association of cone arrestins to the membrane in a light-dependent manner Mus musculus C57/BL6J ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.14 GPCR kinase 1
-
 Mus musculus
2.7.11.14 GRK1
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.14 ATP
-
 Mus musculus