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Literature summary extracted from

  • Wei, F.Y.; Tomizawa, K.; Ohshima, T.; Asada, A.; Saito, T.; Nguyen, C.; Bibb, J.A.; Ishiguro, K.; Kulkarni, A.B.; Pant, H.C.; Mikoshiba, K.; Matsui, H.; Hisanaga, S.
    Control of cyclin-dependent kinase 5 (Cdk5) activity by glutamatergic regulation of p35 stability (2005), J. Neurochem., 93, 502-512.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.22 Calmodulin Ca2+/calmodulin induce the phosphorylation of p35 by Cdk5 after stimulation of the Ca2+-permeable cation channels NMDA receptor and kainate receptor, leading to cleavage of p35 to p25 Mus musculus
2.7.11.22 p25 soluble cofactor of Cdk5, cleavage of p35 to p25 Mus musculus
2.7.11.22 p35 membrane-bound cofactor of Cdk5, levels in primary embryonal cortical neurons are reduced by glutamate-induced stimulation of NMDA or kainate receptors through NMDA or kainate, cleavage of p35 to p25, reduced p35 leads to inhibition of Cdk5 Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.22 additional information p35 null mutant mice have a longer threshold for long term potentiation, overview Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.22 additional information enzyme cofactor p35 levels in primary embryonal cortical neurons are reduced by glutamate-induced stimulation of NMDA or kainate receptors through NMDA or kainate, p35 is reduced via proteasomal degradation, reduced p35 leads to inhibition of Cdk5, no inhibition by casein kinase inhibitor CKI-7 Mus musculus
2.7.11.22 NMDA inactivates Cdk5 by modulation of Ser67 on the protein phosphatase inhibitor-I, overview Mus musculus
2.7.11.22 roscovitine inhibits Cdk5 activity, including the p35 phosphorylation activity Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.22 Ca2+ stimulates Cdk5, Ca2+/calmodulin induce the phosphorylation of p35 by Cdk5 after stimulation of the Ca2+-permeable cation channels NMDA receptor and kainate receptor, leading to cleavage of p35 to p25 Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.22 Mus musculus
-
 ICR mice
-
2.7.11.22 Mus musculus ICR
-
 ICR mice
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.22 phosphoprotein p35 is degraded by the proteasome after stimulation of NMDA or kainate receptors and subsequent Ca2+/calmodulin-dependent phosphorylation of p35 by Cdk5, reduced p35 leads to inhibition of Cdk5 Mus musculus
2.7.11.22 proteolytic modification p35 is degraded by the proteasome after stimulation of NMDA or kainate receptors and subsequent Ca2+/calmodulin-dependent phosphorylation of p35 by Cdk5, p35 is cleaved to p25, reduced p35 leads to inhibition of Cdk5, overview Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.22 brain
-
 Mus musculus
-
2.7.11.22 embryo
-
 Mus musculus
-
2.7.11.22 hippocampus
-
 Mus musculus
-
2.7.11.22 neuron from embryonic brain cortices Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.22 ATP + histone H1
-
 Mus musculus ADP + phosphorylated histone H1
-
 ?
2.7.11.22 ATP + histone H1
-
 Mus musculus ICR ADP + phosphorylated histone H1
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.22 Cdk5
-
 Mus musculus
2.7.11.22 cyclin-dependent kinase 5
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.22 ATP
-
 Mus musculus