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Literature summary extracted from

  • Yamagata, Y.; Obata, K.
    Ca2+/calmodulin-dependent protein kinase II is reversibly autophosphorylated, inactivated and made sedimentable by acute neuronal excitation in rats in vivo (2004), J. Neurochem., 91, 745-754.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.17 Calmodulin kinase activity is dependent on Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.17 particle-bound particulate enzyme shows increased rate of inhibitory autophosphorylation during acute seizure in the brain induced by electroconvulsive treatment Rattus norvegicus
-
-
2.7.11.17 soluble soluble enzyme shows decreased rate of inhibitory autophosphorylation during acute seizure in the brain induced by electroconvulsive treatment Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.17 Ca2+ kinase activity is dependent on Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.17 additional information Rattus norvegicus CaMKII is reversibly, Ca2+/calmodulin-independently autophosphorylated at Thr286alpha and Thr287beta with inhibitory effect, inactivated and made sedimentable by acute neuronal excitation in rats in vivo, regulation, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.17 Rattus norvegicus
-
 male Wistar rats
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.17 phosphoprotein CaMKII performs reversible inhibitory, Ca2+/calmodulin-independent autophosphorylation at Thr286alpha and Thr287beta Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.17 brain hippocampus and parietal cortex Rattus norvegicus
-
2.7.11.17 central nervous system
-
 Rattus norvegicus
-
2.7.11.17 hippocampus
-
 Rattus norvegicus
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2.7.11.17 neuron
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.11.17 additional information
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.17 ATP + PLRRTLSVAA-amide glycogen synthase-derived peptide GSP Rattus norvegicus ADP + phosphorylated PLRRTLSVAA-amide
-
 ?
2.7.11.17 additional information CaMKII is reversibly, Ca2+/calmodulin-independently autophosphorylated at Thr286alpha and Thr287beta with inhibitory effect, inactivated and made sedimentable by acute neuronal excitation in rats in vivo, regulation, overview Rattus norvegicus ?
-
 ?
2.7.11.17 additional information CaMKII performs autophosphorylation Rattus norvegicus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.17 dimer alphabeta Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
2.7.11.17 Ca2+/calmodulin-dependent protein kinase II
-
 Rattus norvegicus
2.7.11.17 CaMKII
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.17 ATP
-
 Rattus norvegicus