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Literature summary extracted from

  • Testai, F.D.; Landek, M.A.; Goswami, R.; Ahmed, M.; Dawson, G.
    Acid sphingomyelinase and inhibition by phosphate ion: role of inhibition by phosphatidyl-myo-inositol 3,4,5-triphosphate in oligodendrocyte cell signaling (2004), J. Neurochem., 89, 636-644.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.12 3',5'-cAMP IC50: above 0.5 mM Homo sapiens
3.1.4.12 5-adenoylimino phosphate IC50: above 0.5 mM Homo sapiens
3.1.4.12 adeno 5'-diphosphate IC50: above 0.5 mM Homo sapiens
3.1.4.12 adeno-2',3'-cyclic phospho 5'-monophosphate IC50: 0.2 mM Homo sapiens
3.1.4.12 adeno-2',3'-cyclic phospho 5'-phosphosulfate IC50: 0.5 mM Homo sapiens
3.1.4.12 ADP IC50: 0.3 mM Homo sapiens
3.1.4.12 AMP IC50: 0.08 mM, non-competitive inhibition Homo sapiens
3.1.4.12 ATP IC50: 0.8 mM Homo sapiens
3.1.4.12 lysophosphatidic acid IC50: 0.04 mM Homo sapiens
3.1.4.12 NAD+ IC50: above 0.5 mM Homo sapiens
3.1.4.12 NADP+ IC50: above 0.5 mM Homo sapiens
3.1.4.12 phosphate IC50: 10 mM, non-competitive inhibition Homo sapiens
3.1.4.12 phosphatidyl-myo-inositol 3,4,5-triphosphate IC50: 0.003 mM Homo sapiens
3.1.4.12 phosphatidyl-myo-inositol 4,5-diphosphate IC50: 0.25 mM Homo sapiens
3.1.4.12 phosphatidylcholine IC50: 2 mM Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 HOG cell human oligodendroglioma cell Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 6-hexadecanoylamino-4-methylumbelliferyl-phosphocholine + H2O
-
 Homo sapiens 6-hexadecanoylamino-4-methylumbelliferone + choline phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 aSMase
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.4.12 0.003
-
 IC50: 0.003 mM Homo sapiens phosphatidyl-myo-inositol 3,4,5-triphosphate
3.1.4.12 0.04
-
 IC50: 0.04 mM Homo sapiens lysophosphatidic acid
3.1.4.12 0.08
-
 IC50: 0.08 mM, non-competitive inhibition Homo sapiens AMP
3.1.4.12 0.2
-
 IC50: 0.2 mM Homo sapiens adeno-2',3'-cyclic phospho 5'-monophosphate
3.1.4.12 0.25
-
 IC50: 0.25 mM Homo sapiens phosphatidyl-myo-inositol 4,5-diphosphate
3.1.4.12 0.3
-
 IC50: 0.3 mM Homo sapiens ADP
3.1.4.12 0.5
-
 IC50: 0.5 mM Homo sapiens adeno-2',3'-cyclic phospho 5'-phosphosulfate
3.1.4.12 0.5
-
 IC50: above 0.5 mM Homo sapiens NAD+
3.1.4.12 0.5
-
 IC50: above 0.5 mM Homo sapiens NADP+
3.1.4.12 0.5
-
 IC50: above 0.5 mM Homo sapiens 3',5'-cAMP
3.1.4.12 0.5
-
 IC50: above 0.5 mM Homo sapiens adeno 5'-diphosphate
3.1.4.12 0.5
-
 IC50: above 0.5 mM Homo sapiens 5-adenoylimino phosphate
3.1.4.12 0.8
-
 IC50: 0.8 mM Homo sapiens ATP
3.1.4.12 2
-
 IC50: 2 mM Homo sapiens phosphatidylcholine
3.1.4.12 10
-
 IC50: 10 mM, non-competitive inhibition Homo sapiens phosphate