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Literature summary extracted from

  • Luo, W.; Yu, Q.s.; Zhan, M.; Parrish, D.; Deschamps, J.R.; Kulkarni, S.S.; Holloway, H.W.; Alley, G.M.; Lahiri, D.K.; Brossi, A.; Greig, N.H.
    Novel anticholinesterases based on the molecular skeletons of furobenzofuran and methanobenzodioxepine (2005), J. Med. Chem., 48, 986-994.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.7 (3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo(2,3-b)indol-5-yl (2-methylphenyl)carbamate 50% inhibition at 10 nM Homo sapiens
3.1.1.7 (3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo(2,3-b)indol-5-yl (4-isopropylphenyl)carbamate 50% inhibition at 760 nM Homo sapiens
3.1.1.7 (3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo(2,3-b)indol-5-yl ethylcarbamate 50% inhibition at 94 nM Homo sapiens
3.1.1.7 (3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo(2,3-b)indol-5-yl methylcarbamate 50% inhibition at 28 nM Homo sapiens
3.1.1.7 (3aR)-3a,8-dimethyl-3,3a,8,8a-tetrahydro-2H-furo(2,3-b)indol-5-yl (2-methylphenyl)carbamate 50% inhibition at 13 nM Homo sapiens
3.1.1.7 (3aR)-3a,8-dimethyl-3,3a,8,8a-tetrahydro-2H-furo(2,3-b)indol-5-yl (4-isopropylphenyl)carbamate 50% inhibition at 3860 nM Homo sapiens
3.1.1.7 (3aR)-3a,8-dimethyl-3,3a,8,8a-tetrahydro-2H-furo(2,3-b)indol-5-yl ethylcarbamate 50% inhibition at 82 nM Homo sapiens
3.1.1.7 (3aR)-3a,8-dimethyl-3,3a,8,8a-tetrahydro-2H-furo(2,3-b)indol-5-yl methylcarbamate 50% inhibition at 27 nM Homo sapiens
3.1.1.7 1-methyl-8,10-dioxatricyclo(7.2.1.0 2,7)dodeca-2,4,6-trien-5-yl (2-methylphenyl)carbamate 50% inhibition at 56 nM Homo sapiens
3.1.1.7 1-methyl-8,10-dioxatricyclo(7.2.1.0 2,7)dodeca-2,4,6-trien-5-yl (4-isopropylphenyl)carbamate 50% inhibition at 4300 nM Homo sapiens
3.1.1.7 1-methyl-8,10-dioxatricyclo(7.2.1.0 2,7)dodeca-2,4,6-trien-5-yl ethylcarbamate 50% inhibition at 830 nM Homo sapiens
3.1.1.7 2'-ethylphenylgeneserine N-oxide 50% inhibition at 125 nM Homo sapiens
3.1.1.7 3a-methyl-2,3,3a,8a-tetrahydrofuro(2,3-b)(1)benzofuran-5-yl (2-methylphenyl)carbamate 50% inhibition at 23 nM Homo sapiens
3.1.1.7 3a-methyl-2,3,3a,8a-tetrahydrofuro(2,3-b)(1)benzofuran-5-yl (4-isopropylphenyl)carbamate 50% inhibition at 2650 nM Homo sapiens
3.1.1.7 3a-methyl-2,3,3a,8a-tetrahydrofuro(2,3-b)(1)benzofuran-5-yl ethylcarbamate 50% inhibition at 360 nM Homo sapiens
3.1.1.7 donepezil 50% inhibition at 22 nM Homo sapiens
3.1.1.7 eptastigmine 50% inhibition at 22 nM Homo sapiens
3.1.1.7 galanthamine 50% inhibition at 800 nM Homo sapiens
3.1.1.7 huperzine A 50% inhibition above 47 nM Homo sapiens
3.1.1.7 additional information comparison of 50% inhibitory concentration for EC 3.1.1.7 and EC 3.1.1.8 Homo sapiens
3.1.1.7 phenserine 50% inhibition at 22 nM Homo sapiens
3.1.1.7 rivastigmine 50% inhibition at 4150 nM Homo sapiens
3.1.1.7 tacrine 50% inhibition at 190 nM Homo sapiens
3.1.1.8 (3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo(2,3-b)indol-5-yl (2-methylphenyl)carbamate 50% inhibition at 1950 nM Homo sapiens
3.1.1.8 (3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo(2,3-b)indol-5-yl (4-isopropylphenyl)carbamate 50% inhibition at 50 nM Homo sapiens
3.1.1.8 (3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo(2,3-b)indol-5-yl ethylcarbamate 50% inhibition at 4 nM Homo sapiens
3.1.1.8 (3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo(2,3-b)indol-5-yl methylcarbamate 50% inhibition at 16 nM Homo sapiens
3.1.1.8 (3aR)-3a,8-dimethyl-3,3a,8,8a-tetrahydro-2H-furo(2,3-b)indol-5-yl (2-methylphenyl)carbamate 50% inhibition at 1560 nM Homo sapiens
3.1.1.8 (3aR)-3a,8-dimethyl-3,3a,8,8a-tetrahydro-2H-furo(2,3-b)indol-5-yl (4-isopropylphenyl)carbamate 50% inhibition at 17 nM Homo sapiens
3.1.1.8 (3aR)-3a,8-dimethyl-3,3a,8,8a-tetrahydro-2H-furo(2,3-b)indol-5-yl ethylcarbamate 50% inhibition at 2 nM Homo sapiens
3.1.1.8 (3aR)-3a,8-dimethyl-3,3a,8,8a-tetrahydro-2H-furo(2,3-b)indol-5-yl methylcarbamate 50% inhibition at 4 nM Homo sapiens
3.1.1.8 1-methyl-8,10-dioxatricyclo(7.2.1.0 2,7)dodeca-2,4,6-trien-5-yl (2-methylphenyl)carbamate 50% inhibition above 0.030 mM Homo sapiens
3.1.1.8 1-methyl-8,10-dioxatricyclo(7.2.1.0 2,7)dodeca-2,4,6-trien-5-yl (4-isopropylphenyl)carbamate 50% inhibition at 22 nM Homo sapiens
3.1.1.8 1-methyl-8,10-dioxatricyclo(7.2.1.0 2,7)dodeca-2,4,6-trien-5-yl ethylcarbamate 50% inhibition at 24 nM Homo sapiens
3.1.1.8 2'-ethylphenylgeneserine N-oxide 50% inhibition at 1700 nM Homo sapiens
3.1.1.8 3a-methyl-2,3,3a,8a-tetrahydrofuro(2,3-b)(1)benzofuran-5-yl (2-methylphenyl)carbamate 50% inhibition above 0.030 mM Homo sapiens
3.1.1.8 3a-methyl-2,3,3a,8a-tetrahydrofuro(2,3-b)(1)benzofuran-5-yl (4-isopropylphenyl)carbamate 50% inhibition at 27 nM Homo sapiens
3.1.1.8 3a-methyl-2,3,3a,8a-tetrahydrofuro(2,3-b)(1)benzofuran-5-yl ethylcarbamate 50% inhibition at 6 nM Homo sapiens
3.1.1.8 donepezil 50% inhibition at 4150 nM Homo sapiens
3.1.1.8 eptastigmine 50% inhibition at 5 nM Homo sapiens
3.1.1.8 galanthamine 50% inhibition at 7300 nM Homo sapiens
3.1.1.8 huperzine A 50% inhibition above 10000 nM Homo sapiens
3.1.1.8 additional information comparison of 50% inhibitory concentration for various inhibitors of EC 3.1.1.7 and EC 3.1.1.8 Homo sapiens
3.1.1.8 phenserine 50% inhibition at 1560 nM Homo sapiens
3.1.1.8 rivastigmine 50% inhibition at 37 nM Homo sapiens
3.1.1.8 tacrine 50% inhibition at 47 nM Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.7 Homo sapiens
-
-
-
3.1.1.8 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.7 erythrocyte
-
 Homo sapiens
-
3.1.1.8 blood plasma
-
 Homo sapiens
-