Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Draganov, D.I.; Teiber, J.F.; Speelman, A.; Osawa, Y.; Sunahara, R.; La Du, B.N.
    Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities (2005), J. Lipid Res., 46, 1239-1247.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.2 the recombinant enzyme is expressed in Trichoplusia ni High Five insect cells Homo sapiens
3.1.1.25 the recombinant enzyme is expressed in Trichoplusia ni High Five insect cells Homo sapiens
3.1.8.1 the recombinant enzyme is expressed in Trichoplusia ni High Five insect cells Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.1.2 39000
-
 2 * 39000, recombinant enzyme Homo sapiens
3.1.1.2 40000
-
 2 * 40000, SDS-PAGE Homo sapiens
3.1.1.2 42000
-
 3 * 42000, recombinant enzyme, SDS-PAGE Homo sapiens
3.1.1.2 91900
-
 serum PON1, nondenaturing PAGE Homo sapiens
3.1.1.2 94900
-
 recombinant enzyme, nondenaturing PAGE Homo sapiens
3.1.1.2 95600
-
 recombinant PON1, nondenaturing PAGE Homo sapiens
3.1.1.2 127500
-
 recombinant enzyme, nondenaturing PAGE Homo sapiens
3.1.1.25 17500
-
 recombinant enzyme, nondenaturing PAGE Homo sapiens
3.1.1.25 39000
-
 2 * 39000, recombinant enzyme Homo sapiens
3.1.1.25 40000
-
 2 * 40000, SDS-PAGE Homo sapiens
3.1.1.25 42000
-
 3 * 42000, recombinant enzyme, SDS-PAGE Homo sapiens
3.1.1.25 91900
-
 serum enzyme, nondenaturing PAGE Homo sapiens
3.1.1.25 94900
-
 recombinant enzyme, nondenaturing PAGE Homo sapiens
3.1.1.25 95600
-
 recombinant enzyme, nondenaturing PAGE Homo sapiens
3.1.8.1 39000
-
 2 * 39000, recombinant enzyme Homo sapiens
3.1.8.1 40000
-
 2 * 40000, recombinant enzyme, SDS-PAGE Homo sapiens
3.1.8.1 91900
-
 serum PON1, nondenaturing PAGE Homo sapiens
3.1.8.1 94900
-
 recombinant enzyme, nondenaturing PAGE Homo sapiens
3.1.8.1 95600
-
 recombinant PON1, nondenaturing PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.2 Homo sapiens P27169
-
-
3.1.1.2 Homo sapiens Q15165
-
-
3.1.1.2 Homo sapiens Q15166
-
-
3.1.1.25 Homo sapiens P27169
-
-
3.1.1.25 Homo sapiens Q15165
-
-
3.1.1.25 Homo sapiens Q15166
-
-
3.1.8.1 Homo sapiens P27169
-
-
3.1.8.1 Homo sapiens Q15166
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.1.2 glycoprotein
-
 Homo sapiens
3.1.1.25 glycoprotein
-
 Homo sapiens
3.1.8.1 glycoprotein
-
 Homo sapiens

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.2
-
 Homo sapiens
3.1.1.25
-
 Homo sapiens
3.1.8.1
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.2 blood serum
-
 Homo sapiens
-
3.1.1.25 blood serum
-
 Homo sapiens
-
3.1.8.1 blood serum
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.1.2 0.086
-
 pH 8.0, 25°C, substrate: phenyl acetate, purified recombinant enzyme Homo sapiens
3.1.1.2 0.7
-
 pH 8.0, 25°C, substrate: 4-nitrophenyl acetate, purified recombinant enzyme Homo sapiens
3.1.1.2 0.96
-
 pH 8.0, 25°C, substrate: 4-nitrophenyl propionate, purified recombinant enzyme Homo sapiens
3.1.1.2 1.3
-
 pH 8.0, 25°C, substrate: 4-nitrophenyl butyrate, purified recombinant enzyme Homo sapiens
3.1.1.2 1.4
-
 pH 8.0, 25°C, substrate: 4-nitrophenyl butyrate, purified recombinant enzyme Homo sapiens
3.1.1.2 4.1
-
 pH 8.0, 25°C, substrate: phenyl acetate, purified recombinant enzyme Homo sapiens
3.1.1.2 11.4
-
 pH 8.0, 25°C, substrate: 4-nitrophenyl butyrate, purified recombinant enzyme Homo sapiens
3.1.1.2 13.6
-
 pH 8.0, 25°C, substrate: 4-nitrophenyl propionate, purified recombinant enzyme Homo sapiens
3.1.1.2 15
-
 pH 8.0, 25°C, substrate: 4-nitrophenyl acetate, purified recombinant enzyme Homo sapiens
3.1.1.2 20.7
-
 pH 8.0, 25°C, substrate: 4-nitrophenyl propionate, purified recombinant enzyme Homo sapiens
3.1.1.2 39
-
 pH 8.0, 25°C, substrate: 4-nitrophenyl acetate, purified recombinant enzyme Homo sapiens
3.1.1.2 1120
-
 pH 8.0, 25°C, substrate: phenyl acetate, purified recombinant enzyme Homo sapiens
3.1.1.25 0.0035
-
 pH 8.0, 25°C, substrate: DL-tetradecanoyl-homoserine lactone, purified recombinant enzyme Homo sapiens
3.1.1.25 0.0036
-
 pH 8.0, 25°C, substrate: DL-heptanoyl-homoserine lactone, purified recombinant enzyme Homo sapiens
3.1.1.25 0.0049
-
 pH 8.0, 25°C, substrate: DL-heptanoyl-homoserine lactone, purified recombinant enzyme Homo sapiens
3.1.1.25 0.011
-
 pH 8.0, 25°C, substrate: spironolactone, purified recombinant enzyme Homo sapiens
3.1.1.25 0.013
-
 pH 8.0, 25°C, substrate: canrenone, purified recombinant enzyme Homo sapiens
3.1.1.25 0.0167
-
 pH 8.0, 25°C, substrate: DL-dodecanoyl-homoserine lactone, purified recombinant enzyme Homo sapiens
3.1.1.25 0.0255
-
 pH 8.0, 25°C, substrate: DL-tetradecanoyl-homoserine lactone, purified recombinant enzyme Homo sapiens
3.1.1.25 0.0268
-
 pH 8.0, 25°C, substrate: DL-3-oxo-hexanoyl-homoserine lactone, purified recombinant enzyme Homo sapiens
3.1.1.25 0.0311
-
 pH 8.0, 25°C, substrate: DL-heptanoyl-homoserine lactone, purified recombinant enzyme Homo sapiens
3.1.1.25 0.0334
-
 pH 8.0, 25°C, substrate: DL-3-oxo-hexanoyl-homoserine lactone, purified recombinant enzyme Homo sapiens
3.1.1.25 0.0977
-
 pH 8.0, 25°C, substrate: DL-dodecanoyl-homoserine lactone, purified recombinant enzyme Homo sapiens
3.1.1.25 0.266
-
 pH 8.0, 25°C, substrate: lovastatin, purified recombinant enzyme Homo sapiens
3.1.1.25 0.4239
-
 pH 8.0, 25°C, substrate: DL-tetradecanoyl-homoserine lactone, purified recombinant enzyme Homo sapiens
3.1.1.25 0.4588
-
 pH 8.0, 25°C, substrate: DL-dodecanoyl-homoserine lactone, purified recombinant enzyme Homo sapiens
3.1.1.25 0.68
-
 pH 8.0, 25°C, substrate: gamma-phenyl-gamma-butyrolactone, purified recombinant enzyme Homo sapiens
3.1.1.25 0.81
-
 pH 8.0, 25°C, substrate: gamma-butyrolactone, purified recombinant enzyme Homo sapiens
3.1.1.25 1.83
-
 pH 8.0, 25°C, substrate: 5-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid 1,5-lactone, purified recombinant enzyme Homo sapiens
3.1.1.25 3.1
-
 pH 8.0, 25°C, substrate: dihydrocoumarin, purified recombinant enzyme Homo sapiens
3.1.1.25 6.2
-
 pH 8.0, 25°C, substrate: gamma-valerolactone, purified recombinant enzyme Homo sapiens
3.1.1.25 10.9
-
 pH 8.0, 25°C, substrate: 2-coumaranone, purified recombinant enzyme Homo sapiens
3.1.1.25 11.1
-
 pH 8.0, 25°C, substrate: delta-nonalactone, purified recombinant enzyme Homo sapiens
3.1.1.25 11.4
-
 pH 8.0, 25°C, substrate: gamma-phenyl-gamma-butyrolactone, purified recombinant enzyme Homo sapiens
3.1.1.25 11.7
-
 pH 8.0, 25°C, substrate: delta-hexalactone, purified recombinant enzyme Homo sapiens
3.1.1.25 14.5
-
 pH 8.0, 25°C, substrate: delta-valerolactone, purified recombinant enzyme Homo sapiens
3.1.1.25 20.7
-
 pH 8.0, 25°C, substrate: alpha-angelicalactone, purified recombinant enzyme Homo sapiens
3.1.1.25 22.7
-
 pH 8.0, 25°C, substrate: delta-tetradecanolactone, purified recombinant enzyme Homo sapiens
3.1.1.25 23.9
-
 pH 8.0, 25°C, substrate: gamma-hexalactone, purified recombinant enzyme Homo sapiens
3.1.1.25 25.6
-
 pH 8.0, 25°C, substrate: gamma-octalactone, purified recombinant enzyme Homo sapiens
3.1.1.25 27.5
-
 pH 8.0, 25°C, substrate: 5-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid 1,5-lactone, purified recombinant enzyme Homo sapiens
3.1.1.25 27.7
-
 pH 8.0, 25°C, substrate: gamma-heptalactone, purified recombinant enzyme Homo sapiens
3.1.1.25 30.9
-
 pH 8.0, 25°C, substrate: gamma-nonalactone, purified recombinant enzyme Homo sapiens
3.1.1.25 32.1
-
 pH 8.0, 25°C, substrate: gamma-butyrolactone, purified recombinant enzyme Homo sapiens
3.1.1.25 40.7
-
 pH 8.0, 25°C, substrate: 2-coumaranone, purified recombinant enzyme Homo sapiens
3.1.1.25 44.3
-
 pH 8.0, 25°C, substrate: delta-decanolactone, purified recombinant enzyme Homo sapiens
3.1.1.25 45
-
 pH 8.0, 25°C, substrate: gamma-valerolactone, purified recombinant enzyme Homo sapiens
3.1.1.25 45.6
-
 pH 8.0, 25°C, substrate: gamma-decanolactone, purified recombinant enzyme Homo sapiens
3.1.1.25 51.7
-
 pH 8.0, 25°C, substrate: gamma-hexalactone, purified recombinant enzyme Homo sapiens
3.1.1.25 57.2
-
 pH 8.0, 25°C, substrate: gamma-heptalactone, purified recombinant enzyme Homo sapiens
3.1.1.25 63
-
 pH 8.0, 25°C, substrate: gamma-phenyl-gamma-butyrolactone, purified recombinant enzyme Homo sapiens
3.1.1.25 69.2
-
 pH 8.0, 25°C, substrate: gamma-octalactone, purified recombinant enzyme Homo sapiens
3.1.1.25 71.4
-
 pH 8.0, 25°C, substrate: gamma-undecanolactone, purified recombinant enzyme Homo sapiens
3.1.1.25 72
-
 pH 8.0, 25°C, substrate: delta-hexalactone, purified recombinant enzyme Homo sapiens
3.1.1.25 75.4
-
 pH 8.0, 25°C, substrate: 5-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid 1,5-lactone, purified recombinant enzyme Homo sapiens
3.1.1.25 84.4
-
 pH 8.0, 25°C, substrate: delta-undecanolactone, purified recombinant enzyme Homo sapiens
3.1.1.25 126.1
-
 pH 8.0, 25°C, substrate: dihydrocoumarin, purified recombinant enzyme Homo sapiens
3.1.1.25 127.6
-
 pH 8.0, 25°C, substrate: gamma-undecanolactone, purified recombinant enzyme Homo sapiens
3.1.1.25 129.9
-
 pH 8.0, 25°C, substrate: dihydrocoumarin, purified recombinant enzyme Homo sapiens
3.1.1.25 135.7
-
 pH 8.0, 25°C, substrate: 2-coumaranone, purified recombinant enzyme Homo sapiens
3.1.1.25 144.7
-
 pH 8.0, 25°C, substrate: gamma-nonalactone, purified recombinant enzyme Homo sapiens
3.1.1.25 150
-
 pH 8.0, 25°C, substrate: delta-nonalactone, purified recombinant enzyme Homo sapiens
3.1.1.25 154
-
 pH 8.0, 25°C, substrate: delta-tetradecanolactone, purified recombinant enzyme Homo sapiens
3.1.1.25 173.8
-
 pH 8.0, 25°C, substrate: gamma-decanolactone, purified recombinant enzyme Homo sapiens
3.1.1.25 183
-
 pH 8.0, 25°C, substrate: alpha-angelicalactone, purified recombinant enzyme Homo sapiens
3.1.1.25 251
-
 pH 8.0, 25°C, substrate: delta-decanolactone, purified recombinant enzyme Homo sapiens
3.1.1.25 287
-
 pH 8.0, 25°C, substrate: delta-undecanolactone, purified recombinant enzyme Homo sapiens
3.1.1.25 329.5
-
 pH 8.0, 25°C, substrate: homogentisic acid lactone, purified recombinant enzyme Homo sapiens
3.1.1.25 671
-
 pH 8.0, 25°C, substrate: delta-valerolactone, purified recombinant enzyme Homo sapiens
3.1.8.1 0.205
-
 pH 8.5, 25°C, substrate: paraoxon, purified recombinant enzyme Homo sapiens
3.1.8.1 1.94
-
 pH 8.5, 25°C, substrate: paraoxon, purified recombinant enzyme Homo sapiens
3.1.8.1 40.9
-
 pH 8.5, 25°C, substrate: chlorpyrifos oxon, purified recombinant enzyme Homo sapiens
3.1.8.1 113
-
 pH 8.5, 25°C, substrate: diazoxon, purified recombinant enzyme Homo sapiens

Storage Stability

EC Number Storage Stability Organism
3.1.1.2 4°C, 6 months, less than 15% loss of activity Homo sapiens
3.1.1.2 4°C, purified recombinant PON1 preparations typically lose about 20% of the arylesterase activity within the first month after purification, compared with less than 10% loss for the enzyme purified from serum. There is no further significant loss of the PON1 activity afterward, suggesting the existence of two pools in the purified PON1, a labile one and a stable one Homo sapiens
3.1.1.25 4°C, 6 months, less than 15% loss of activity Homo sapiens
3.1.1.25 4°C, purified recombinant enzyme preparations typically lose about 20% of the arylesterase activity within the first month after purification, compared with less than 10% loss for the enzyme purified from serum. There is no further significant loss of the enzyme activity afterward, suggesting the existence of two pools in the purified enzyme, a labile one and a stable one Homo sapiens
3.1.8.1 4°C, 6 months, less than 15% loss of activity Homo sapiens
3.1.8.1 4°C, purified recombinant PON1 preparations typically lose about 20% of the arylesterase activity within the first month after purification, compared with less than 10% loss for the enzyme purified from serum. There is no further significant loss of the PON1 activity afterward, suggesting the existence of two pools in the purified PON1, a labile one and a stable one Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.2 4-nitrophenyl acetate + H2O activity is 2.6fold higher than that with PON1 (P27169 (UniProt)) Homo sapiens 4-nitrophenol + acetate
-
 ?
3.1.1.2 4-nitrophenyl acetate + H2O activity is about 40% of the activity with PON3 (Q15166 (UniProt)) Homo sapiens 4-nitrophenol + acetate
-
 ?
3.1.1.2 4-nitrophenyl acetate + H2O activity is about 5% of that with PON1 (P27169 (UniProt)) Homo sapiens 4-nitrophenol + acetate
-
 ?
3.1.1.2 4-nitrophenyl butyrate + H2O activity is similar to that with PON1 (P27169 (UniProt)) Homo sapiens 4-nitrophenol + butyrate
-
 ?
3.1.1.2 4-nitrophenyl propionate + H2O activity is 1.5fold higher than that with PON1 (P27169 (UniProt)) Homo sapiens 4-nitrophenol + propionate
-
 ?
3.1.1.2 4-nitrophenyl propionate + H2O activity is 8.7fold higher than that with PON1 (P27169 (UniProt)) Homo sapiens 4-nitrophenol + propionate
-
 ?
3.1.1.2 4-nitrophenyl propionate + H2O activity is about 10% of the activity with PON3 (Q15166 (UniProt)) Homo sapiens 4-nitrophenol + propionate
-
 ?
3.1.1.2 4-nitrophenyl propionate + H2O activity is about 65% of the activity with PON3 (Q15166 (UniProt)) Homo sapiens 4-nitrophenol + propionate
-
 ?
3.1.1.2 4-nitrophenyl propionate + H2O activity is about 7% of that with PON1 (P27169 (UniProt)) Homo sapiens 4-nitrophenol + propionate
-
 ?
3.1.1.2 phenyl acetate + H2O activity is less than 1% of that with PON1 (P27169 (UniProt)) Homo sapiens phenol + acetate
-
 ?
3.1.1.2 phenyl acetate + H2O activity is more than 100fold higher than with PON2 (Q15165 (UniProt)) and PON3 (Q15166 (UniProt)) Homo sapiens phenol + acetate
-
 ?
3.1.1.25 2-coumaranone + H2O
-
 Homo sapiens (2-hydroxyphenyl)acetic acid
-
 ?
3.1.1.25 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoic acid 1,5-lactone + H2O
-
 Homo sapiens 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoic acid
-
 ?
3.1.1.25 5-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid 1,5-lactone + H2O
-
 Homo sapiens 5-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid
-
 ?
3.1.1.25 alpha-angelicalactone + H2O
-
 Homo sapiens 4-hydroxy-pent-3-enoic acid
-
 ?
3.1.1.25 alpha-angelicalactone + H2O
-
 Homo sapiens 4-hydroxypent-3-enoic acid
-
 ?
3.1.1.25 canrenone + H2O not hydrolyzed by PON1 (P27169 (UniProt)) and PON2 (Q15165 (UniProt)) Homo sapiens ?
-
 ?
3.1.1.25 delta-decanolactone + H2O
-
 Homo sapiens 5-hydroxydecanoic acid
-
 ?
3.1.1.25 delta-hexalactone + H2O
-
 Homo sapiens 5-hydroxyhexanoic acid
-
 ?
3.1.1.25 delta-nonalactone + H2O
-
 Homo sapiens 5-hydroxynonanoic acid
-
 ?
3.1.1.25 delta-tetradecanolactone + H2O
-
 Homo sapiens 5-hydroxytetradecanoic acid
-
 ?
3.1.1.25 delta-undecanolactone + H2O
-
 Homo sapiens 5-hydroxyundecanoic acid
-
 ?
3.1.1.25 delta-valerolactone + H2O
-
 Homo sapiens 5-hydroxypentanoic acid
-
 ?
3.1.1.25 dihydrocoumarin + H2O
-
 Homo sapiens 3-(2-hydroxyphenyl)propanoic acid
-
 ?
3.1.1.25 DL-3-oxo-hexanoyl-homoserine lactone + H2O
-
 Homo sapiens DL-3-oxo-hexanoyl-homoserine
-
 ?
3.1.1.25 DL-3-oxo-hexanoylhomoserine lactone + H2O
-
 Homo sapiens DL-3-oxo-hexanoylhomoserine
-
 ?
3.1.1.25 DL-dodecanoyl-homoserine lactone + H2O
-
 Homo sapiens DL-dodecanoyl-homoserine
-
 ?
3.1.1.25 DL-dodecanoylhomoserine lactone + H2O
-
 Homo sapiens DL-dodecanoylhomoserine
-
 ?
3.1.1.25 DL-heptanoyl-homoserine lactone + H2O
-
 Homo sapiens DL-heptanoyl-homoserine
-
 ?
3.1.1.25 DL-heptanoylhomoserine lactone + H2O
-
 Homo sapiens DL-heptanoylhomoserine
-
 ?
3.1.1.25 DL-tetradecanoyl-homoserine lactone + H2O
-
 Homo sapiens DL-tetradecanoyl-homoserine
-
 ?
3.1.1.25 DL-tetradecanoylhomoserine lactone + H2O
-
 Homo sapiens DL-tetradecanoyl-homoserine
-
 ?
3.1.1.25 DL-tetradecanoylhomoserine lactone + H2O
-
 Homo sapiens DL-tetradecanoylhomoserine
-
 ?
3.1.1.25 gamma-butyrolactone + H2O
-
 Homo sapiens 4-hydroxy-butyric acid
-
 ?
3.1.1.25 gamma-butyrolactone + H2O
-
 Homo sapiens 4-hydroxybutyric acid
-
 ?
3.1.1.25 gamma-decanolactone + H2O
-
 Homo sapiens 4-hydroxydecanoic acid
-
 ?
3.1.1.25 gamma-heptalactone + H2O
-
 Homo sapiens 4-hydroxyheptanoic acid
-
 ?
3.1.1.25 gamma-hexalactone + H2O
-
 Homo sapiens 4-hydroxyhexanoic acid
-
 ?
3.1.1.25 gamma-nonalactone + H2O
-
 Homo sapiens 4-hydroxynonanoic acid
-
 ?
3.1.1.25 gamma-octalactone + H2O
-
 Homo sapiens 4-hydroxyoctanoic acid
-
 ?
3.1.1.25 gamma-phenyl-gamma-butyrolactone + H2O
-
 Homo sapiens 4-hydroxy-4-phenyl-butanoic acid
-
 ?
3.1.1.25 gamma-phenyl-gamma-butyrolactone + H2O
-
 Homo sapiens 4-hydroxy-4-phenylbutanoic acid
-
 ?
3.1.1.25 gamma-undecanolactone + H2O
-
 Homo sapiens 4-hydroxyundecanoic acid
-
 ?
3.1.1.25 gamma-valerolactone + H2O
-
 Homo sapiens 4-hydroxypentanoic acid
-
 ?
3.1.1.25 homogentisic acid lactone + H2O
-
 Homo sapiens homogentisic acid
-
 ?
3.1.1.25 lovastatin + H2O not hydrolyzed by PON1 (P27169 (UniProt)) and PON2 (Q15165 (UniProt)) Homo sapiens ?
-
 ?
3.1.1.25 additional information no activity with homogentisic acid lactone and DL-3-oxo-hexanoyl-homoserine lactone Homo sapiens ?
-
 ?
3.1.1.25 additional information no activity with lovastatin, spironolactone or canrenone Homo sapiens ?
-
 ?
3.1.1.25 additional information no activity with lovastatin, spironolactone, canrenone, homogentisic acid lactone, gamma-butyrolactone, gamma-valerolactone, gamma-hexalactone, gamma-heptalactone, gamma-octalactone, gamma-nonalactone, gamma-decanolactone, gamma-undecanolactone, alpha-angelicalactone, delta-valerolactone, delta-hexalactone, delta-nonalactone, delta-decanolactone, delta-undecanolactone, delta-tetradecanolactone Homo sapiens ?
-
 ?
3.1.1.25 spironolactone + H2O not hydrolyzed by PON1 (P27169 (UniProt)) and PON2 (Q15165 (UniProt)) Homo sapiens ?
-
 ?
3.1.8.1 chlorpyrifos oxon + H2O
-
 Homo sapiens 3,5,6-trichloro-pyridin-2-ol + diethyl phosphate
-
 ?
3.1.8.1 diazoxon + H2O
-
 Homo sapiens ?
-
 ?
3.1.8.1 additional information no activity with chlorpyrifos oxon and diazoxon Homo sapiens ?
-
 ?
3.1.8.1 paraoxon + H2O
-
 Homo sapiens 4-nitrophenol + diethyl phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.1.2 dimer 2 * 40000, SDS-PAGE Homo sapiens
3.1.1.2 dimer 2 * 39000, recombinant enzyme Homo sapiens
3.1.1.2 trimer 3 * 42000, recombinant enzyme, SDS-PAGE Homo sapiens
3.1.1.25 dimer 2 * 40000, SDS-PAGE Homo sapiens
3.1.1.25 dimer 2 * 39000, recombinant enzyme Homo sapiens
3.1.1.25 trimer 3 * 42000, recombinant enzyme, SDS-PAGE Homo sapiens
3.1.8.1 dimer 2 * 40000, recombinant enzyme, SDS-PAGE Homo sapiens
3.1.8.1 dimer 2 * 39000, recombinant enzyme Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.1.8.1 PON1
-
 Homo sapiens
3.1.8.1 PON3
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.2 25
-
 assay at Homo sapiens
3.1.1.25 25
-
 assay at Homo sapiens
3.1.8.1 25
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.2 8
-
 assay at Homo sapiens
3.1.1.25 8
-
 assay at Homo sapiens
3.1.8.1 8.5
-
 assay at Homo sapiens