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Literature summary extracted from

  • Mansour, M.; Tornhamre, S.
    Inhibition of 5-lipoxygenase and leukotriene C4 synthase in human blood cells by thymoquinone (2004), J. Enzyme Inhib. Med. Chem., 19, 431-436.
    View publication on PubMed

Application

EC Number Application Comment Organism
4.4.1.20 drug development leukotrienes are an important therapeutic target in asthma and inflammatory diseases Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.4.1.20 2-methyl-5-(1-methylethyl)cyclohexa-2,5-diene-1,4-dione
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.4.1.20 leukotriene C4 Homo sapiens
-
 leukotriene A4 + glutathione
-
 r

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.20 Homo sapiens Q16873
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.4.1.20 leukocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.20 leukotriene A4 + glutathione
-
 Homo sapiens leukotriene C4
-
 r
4.4.1.20 leukotriene C4
-
 Homo sapiens leukotriene A4 + glutathione
-
 r

Synonyms

EC Number Synonyms Comment Organism
4.4.1.20 leukotriene C4 synthase
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.4.1.20 0.01
-
 2-methyl-5-(1-methylethyl)cyclohexa-2,5-diene-1,4-dione IC50 value Homo sapiens