BRENDA - Enzyme Database

Lipid phosphate phosphatases and related proteins: signaling functions in development, cell division, and cancer

Brindley, D.N.; J. Cell. Biochem. 92, 900-912 (2004)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
3.1.3.4
additional information
treatment of HeLa cells with the epidermal growth factor leads to 3fold increased LPP-3 expression, while LPP-1 expression is unaffected, LPP-1 expression is increased in prostate adenocarcinoma cells treated with androgens
Homo sapiens
Cloned(Commentary)
EC Number
Commentary
Organism
3.1.3.4
overexpression of LPP-3 in HEK293 cells and in Xenopus laevis dorsal blastomeres of embryos causing a mild ventralizing effect
Homo sapiens
Engineering
EC Number
Amino acid exchange
Commentary
Organism
3.1.3.4
additional information
introduction of LPP-3 into Drosophila melanogaster germ cells causes aberrant migration and germ cell death
Homo sapiens
3.1.3.4
additional information
construction of several mouse models overexpressing or lacking LPP isozymes, e.g. overexpression of LPP-1 leads to defects in fertility in female mice and to increased accumulation of diacylglycerol, LPP-2 knockout mice are fertile and viable, whereas LPP-3 knockout mice show a severe phenotype failing to form a chorio-allantoic placenta and yolk sac vasculature, in addition, mutant embryos show a shortening of the anterior-posterior axis, overview, introduction of LPP-1 into Drosophila melanogaster germ cells has no effect on the germ-cell-specific factor in vivo
Mus musculus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.1.3.4
additional information
the enzymes act intra- and extracellularly
Drosophila melanogaster
-
-
3.1.3.4
additional information
the enzymes act intra- and extracellularly; the enzymes act intra- and extracellularly; the enzymes act intra- and extracellularly; the enzymes act intra- and extracellularly
Homo sapiens
-
-
3.1.3.4
additional information
the enzymes act intra- and extracellularly
Mus musculus
-
-
3.1.3.4
additional information
the enzymes act intra- and extracellularly
Rattus norvegicus
-
-
3.1.3.4
plasma membrane
the isozyme LPP-1 is partly expressed in the plama membrane with its C-terminal end located on the cell surface
Drosophila melanogaster
5886
-
3.1.3.4
plasma membrane
isozyme LPP-1, containing the apical sorting signal FDKTRL, is mainly located at the apical surface membrane, while isozyme LPP-3 is located at the basolateral membrane being targeted by the dityrosine motif in the second cytoplasmic portion; isozyme LPP-1, containing the apical sorting signal FDKTRL, is mainly located at the apical surface membrane, while isozyme LPP-3 is located at the basolateral membrane being targeted by the dityrosine motif in the second cytoplasmic portion; isozyme LPP-1, containing the apical sorting signal FDKTRL, is mainly located at the apical surface membrane, while isozyme LPP-3 is located at the basolateral membrane being targeted by the dityrosine motif in the second cytoplasmic portion; isozyme LPP-1, containing the apical sorting signal FDKTRL, is mainly located at the apical surface membrane, while isozyme LPP-3 is located at the basolateral membrane being targeted by the dityrosine motif in the second cytoplasmic portion
Homo sapiens
5886
-
3.1.3.4
plasma membrane
-
Mus musculus
5886
-
3.1.3.4
plasma membrane
-
Rattus norvegicus
5886
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.3.4
lysophosphatidic acid + H2O
Drosophila melanogaster
-
monoacylglycerol + phosphate
-
-
?
3.1.3.4
lysophosphatidic acid + H2O
Mus musculus
-
monoacylglycerol + phosphate
-
-
?
3.1.3.4
lysophosphatidic acid + H2O
Rattus norvegicus
-
monoacylglycerol + phosphate
-
-
?
3.1.3.4
lysophosphatidic acid + H2O
Homo sapiens
-
monoacylglycerol + phosphate
-
-
?
3.1.3.4
additional information
Homo sapiens
LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, LPP-3 is involved in embryonal axis patterning, overview
?
-
-
-
3.1.3.4
additional information
Mus musculus
LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, overview
?
-
-
-
3.1.3.4
additional information
Rattus norvegicus
LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, overview
?
-
-
-
3.1.3.4
additional information
Homo sapiens
LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, overview
?
-
-
-
3.1.3.4
additional information
Drosophila melanogaster
LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, Wunen and Wunen2 are essential for germ cell development, overview
?
-
-
-
3.1.3.4
additional information
Homo sapiens
LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, overview, expression of PRG-1 in neurons increases extracellular lysophosphatidic acid breakdown and attenuates LPA-induced axonal retraction, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, overview
?
-
-
-
3.1.3.4
sphingosine 1-phosphate + H2O
Drosophila melanogaster
-
sphingosine + phosphate
-
-
?
3.1.3.4
sphingosine 1-phosphate + H2O
Mus musculus
-
sphingosine + phosphate
-
-
?
3.1.3.4
sphingosine 1-phosphate + H2O
Rattus norvegicus
-
sphingosine + phosphate
-
-
?
3.1.3.4
sphingosine 1-phosphate + H2O
Homo sapiens
-
sphingosine + phosphate
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.1.3.4
Drosophila melanogaster
-
genes Wun and Wun2
-
3.1.3.4
Homo sapiens
Q6T4P5
LPR-3; LPR-3
-
3.1.3.4
Homo sapiens
Q7Z2D5
PRG-1 or LPR-4; PRG-1 or LPR-4
-
3.1.3.4
Homo sapiens
Q8TBJ4
PRG-3 or LPR-1; isozyme PRG-3 or LPR-1
-
3.1.3.4
Homo sapiens
Q96GM1
LPR-2 or PRG-4; PRG-4 or LPR-2
-
3.1.3.4
Mus musculus
-
several isozymes, e.g. isozyme PAP2A, i.e. LPP-1
-
3.1.3.4
Rattus norvegicus
-
-
-
Posttranslational Modification
EC Number
Posttranslational Modification
Commentary
Organism
3.1.3.4
glycoprotein
N-glycosylation
Drosophila melanogaster
3.1.3.4
glycoprotein
N-glycosylation; N-glycosylation; N-glycosylation; N-glycosylation
Homo sapiens
3.1.3.4
glycoprotein
N-glycosylation
Mus musculus
3.1.3.4
glycoprotein
N-glycosylation
Rattus norvegicus
Reaction
EC Number
Reaction
Commentary
Organism
3.1.3.4
a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate
the active site of plasma membrane LPP-1, LPP-2, and LPP-3 is outside the cell, the conserved phosphatase family amino acids are essential for catalytic activity
Drosophila melanogaster
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.3.4
aorta
-
Homo sapiens
-
3.1.3.4
bladder
-
Homo sapiens
-
3.1.3.4
brain
LPP-2 predominantly
Homo sapiens
-
3.1.3.4
heart
LPP-1a predominantly
Homo sapiens
-
3.1.3.4
HeLa cell
-
Homo sapiens
-
3.1.3.4
intestinal mucosa
epithelial differentiation of intestinal mucosa leads to increased Dri-42/LPP-3 expression
Rattus norvegicus
-
3.1.3.4
kidney
LPP-1 predominantly
Homo sapiens
-
3.1.3.4
liver
LPP-1 predominantly
Homo sapiens
-
3.1.3.4
lung
LPP-1 predominantly
Homo sapiens
-
3.1.3.4
additional information
tissue distribution; tissue distribution; tissue distribution; tissue distribution
Homo sapiens
-
3.1.3.4
neuron
expression of PRG-1
Homo sapiens
-
3.1.3.4
pancreas
LPP-2 predominantly
Homo sapiens
-
3.1.3.4
placenta
LPP-1 predominantly; LPP-2 predominantly
Homo sapiens
-
3.1.3.4
prostate adenocarcinoma cell
LPP-1
Homo sapiens
-
3.1.3.4
prostate gland
-
Homo sapiens
-
3.1.3.4
uterus
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.3.4
ceramide 1-phosphate + H2O
-
665805
Drosophila melanogaster
ceramide + phosphate
-
-
-
?
3.1.3.4
ceramide 1-phosphate + H2O
-
665805
Mus musculus
ceramide + phosphate
-
-
-
?
3.1.3.4
ceramide 1-phosphate + H2O
-
665805
Rattus norvegicus
ceramide + phosphate
-
-
-
?
3.1.3.4
ceramide 1-phosphate + H2O
-
665805
Homo sapiens
ceramide + phosphate
-
-
-
?
3.1.3.4
lysophosphatidic acid + H2O
-
665805
Drosophila melanogaster
monoacylglycerol + phosphate
-
-
-
?
3.1.3.4
lysophosphatidic acid + H2O
-
665805
Mus musculus
monoacylglycerol + phosphate
-
-
-
?
3.1.3.4
lysophosphatidic acid + H2O
-
665805
Rattus norvegicus
monoacylglycerol + phosphate
-
-
-
?
3.1.3.4
lysophosphatidic acid + H2O
-
665805
Homo sapiens
monoacylglycerol + phosphate
-
-
-
?
3.1.3.4
additional information
LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, LPP-3 is involved in embryonal axis patterning, overview
665805
Homo sapiens
?
-
-
-
-
3.1.3.4
additional information
LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, overview
665805
Mus musculus
?
-
-
-
-
3.1.3.4
additional information
LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, overview
665805
Rattus norvegicus
?
-
-
-
-
3.1.3.4
additional information
LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, overview
665805
Homo sapiens
?
-
-
-
-
3.1.3.4
additional information
LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, Wunen and Wunen2 are essential for germ cell development, overview
665805
Drosophila melanogaster
?
-
-
-
-
3.1.3.4
additional information
LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, overview, expression of PRG-1 in neurons increases extracellular lysophosphatidic acid breakdown and attenuates LPA-induced axonal retraction, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, overview
665805
Homo sapiens
?
-
-
-
-
3.1.3.4
additional information
Wunen does not interact with Wunen2
665805
Drosophila melanogaster
?
-
-
-
-
3.1.3.4
phosphatidic acid + H2O
-
665805
Drosophila melanogaster
diacylglycerol + phosphate
-
-
-
?
3.1.3.4
phosphatidic acid + H2O
-
665805
Mus musculus
diacylglycerol + phosphate
-
-
-
?
3.1.3.4
phosphatidic acid + H2O
-
665805
Rattus norvegicus
diacylglycerol + phosphate
-
-
-
?
3.1.3.4
phosphatidic acid + H2O
-
665805
Homo sapiens
diacylglycerol + phosphate
-
-
-
?
3.1.3.4
sphingosine 1-phosphate + H2O
-
665805
Drosophila melanogaster
sphingosine + phosphate
-
-
-
?
3.1.3.4
sphingosine 1-phosphate + H2O
-
665805
Mus musculus
sphingosine + phosphate
-
-
-
?
3.1.3.4
sphingosine 1-phosphate + H2O
-
665805
Rattus norvegicus
sphingosine + phosphate
-
-
-
?
3.1.3.4
sphingosine 1-phosphate + H2O
-
665805
Homo sapiens
sphingosine + phosphate
-
-
-
?
Subunits
EC Number
Subunits
Commentary
Organism
3.1.3.4
More
the LPPs contain three conserved active site domains and six conserved transmembrane domains
Drosophila melanogaster
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
3.1.3.4
additional information
treatment of HeLa cells with the epidermal growth factor leads to 3fold increased LPP-3 expression, while LPP-1 expression is unaffected, LPP-1 expression is increased in prostate adenocarcinoma cells treated with androgens
Homo sapiens
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
3.1.3.4
overexpression of LPP-3 in HEK293 cells and in Xenopus laevis dorsal blastomeres of embryos causing a mild ventralizing effect
Homo sapiens
Engineering (protein specific)
EC Number
Amino acid exchange
Commentary
Organism
3.1.3.4
additional information
introduction of LPP-3 into Drosophila melanogaster germ cells causes aberrant migration and germ cell death
Homo sapiens
3.1.3.4
additional information
construction of several mouse models overexpressing or lacking LPP isozymes, e.g. overexpression of LPP-1 leads to defects in fertility in female mice and to increased accumulation of diacylglycerol, LPP-2 knockout mice are fertile and viable, whereas LPP-3 knockout mice show a severe phenotype failing to form a chorio-allantoic placenta and yolk sac vasculature, in addition, mutant embryos show a shortening of the anterior-posterior axis, overview, introduction of LPP-1 into Drosophila melanogaster germ cells has no effect on the germ-cell-specific factor in vivo
Mus musculus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.1.3.4
additional information
the enzymes act intra- and extracellularly
Drosophila melanogaster
-
-
3.1.3.4
additional information
the enzymes act intra- and extracellularly
Homo sapiens
-
-
3.1.3.4
additional information
the enzymes act intra- and extracellularly
Mus musculus
-
-
3.1.3.4
additional information
the enzymes act intra- and extracellularly
Rattus norvegicus
-
-
3.1.3.4
plasma membrane
the isozyme LPP-1 is partly expressed in the plama membrane with its C-terminal end located on the cell surface
Drosophila melanogaster
5886
-
3.1.3.4
plasma membrane
isozyme LPP-1, containing the apical sorting signal FDKTRL, is mainly located at the apical surface membrane, while isozyme LPP-3 is located at the basolateral membrane being targeted by the dityrosine motif in the second cytoplasmic portion
Homo sapiens
5886
-
3.1.3.4
plasma membrane
-
Mus musculus
5886
-
3.1.3.4
plasma membrane
-
Rattus norvegicus
5886
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.3.4
lysophosphatidic acid + H2O
Drosophila melanogaster
-
monoacylglycerol + phosphate
-
-
?
3.1.3.4
lysophosphatidic acid + H2O
Mus musculus
-
monoacylglycerol + phosphate
-
-
?
3.1.3.4
lysophosphatidic acid + H2O
Rattus norvegicus
-
monoacylglycerol + phosphate
-
-
?
3.1.3.4
lysophosphatidic acid + H2O
Homo sapiens
-
monoacylglycerol + phosphate
-
-
?
3.1.3.4
additional information
Homo sapiens
LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, LPP-3 is involved in embryonal axis patterning, overview
?
-
-
-
3.1.3.4
additional information
Mus musculus
LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, overview
?
-
-
-
3.1.3.4
additional information
Rattus norvegicus
LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, overview
?
-
-
-
3.1.3.4
additional information
Homo sapiens
LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, overview
?
-
-
-
3.1.3.4
additional information
Drosophila melanogaster
LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, Wunen and Wunen2 are essential for germ cell development, overview
?
-
-
-
3.1.3.4
additional information
Homo sapiens
LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, overview, expression of PRG-1 in neurons increases extracellular lysophosphatidic acid breakdown and attenuates LPA-induced axonal retraction, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, overview
?
-
-
-
3.1.3.4
sphingosine 1-phosphate + H2O
Drosophila melanogaster
-
sphingosine + phosphate
-
-
?
3.1.3.4
sphingosine 1-phosphate + H2O
Mus musculus
-
sphingosine + phosphate
-
-
?
3.1.3.4
sphingosine 1-phosphate + H2O
Rattus norvegicus
-
sphingosine + phosphate
-
-
?
3.1.3.4
sphingosine 1-phosphate + H2O
Homo sapiens
-
sphingosine + phosphate
-
-
?
Posttranslational Modification (protein specific)
EC Number
Posttranslational Modification
Commentary
Organism
3.1.3.4
glycoprotein
N-glycosylation
Drosophila melanogaster
3.1.3.4
glycoprotein
N-glycosylation
Homo sapiens
3.1.3.4
glycoprotein
N-glycosylation
Mus musculus
3.1.3.4
glycoprotein
N-glycosylation
Rattus norvegicus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.3.4
aorta
-
Homo sapiens
-
3.1.3.4
bladder
-
Homo sapiens
-
3.1.3.4
brain
LPP-2 predominantly
Homo sapiens
-
3.1.3.4
brain
-
Homo sapiens
-
3.1.3.4
heart
-
Homo sapiens
-
3.1.3.4
heart
LPP-1a predominantly
Homo sapiens
-
3.1.3.4
HeLa cell
-
Homo sapiens
-
3.1.3.4
intestinal mucosa
epithelial differentiation of intestinal mucosa leads to increased Dri-42/LPP-3 expression
Rattus norvegicus
-
3.1.3.4
kidney
-
Homo sapiens
-
3.1.3.4
kidney
LPP-1 predominantly
Homo sapiens
-
3.1.3.4
liver
-
Homo sapiens
-
3.1.3.4
liver
LPP-1 predominantly
Homo sapiens
-
3.1.3.4
lung
-
Homo sapiens
-
3.1.3.4
lung
LPP-1 predominantly
Homo sapiens
-
3.1.3.4
additional information
tissue distribution
Homo sapiens
-
3.1.3.4
neuron
expression of PRG-1
Homo sapiens
-
3.1.3.4
pancreas
LPP-2 predominantly
Homo sapiens
-
3.1.3.4
pancreas
-
Homo sapiens
-
3.1.3.4
placenta
LPP-2 predominantly
Homo sapiens
-
3.1.3.4
placenta
-
Homo sapiens
-
3.1.3.4
placenta
LPP-1 predominantly
Homo sapiens
-
3.1.3.4
prostate adenocarcinoma cell
LPP-1
Homo sapiens
-
3.1.3.4
prostate gland
-
Homo sapiens
-
3.1.3.4
uterus
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.3.4
ceramide 1-phosphate + H2O
-
665805
Drosophila melanogaster
ceramide + phosphate
-
-
-
?
3.1.3.4
ceramide 1-phosphate + H2O
-
665805
Mus musculus
ceramide + phosphate
-
-
-
?
3.1.3.4
ceramide 1-phosphate + H2O
-
665805
Rattus norvegicus
ceramide + phosphate
-
-
-
?
3.1.3.4
ceramide 1-phosphate + H2O
-
665805
Homo sapiens
ceramide + phosphate
-
-
-
?
3.1.3.4
lysophosphatidic acid + H2O
-
665805
Drosophila melanogaster
monoacylglycerol + phosphate
-
-
-
?
3.1.3.4
lysophosphatidic acid + H2O
-
665805
Mus musculus
monoacylglycerol + phosphate
-
-
-
?
3.1.3.4
lysophosphatidic acid + H2O
-
665805
Rattus norvegicus
monoacylglycerol + phosphate
-
-
-
?
3.1.3.4
lysophosphatidic acid + H2O
-
665805
Homo sapiens
monoacylglycerol + phosphate
-
-
-
?
3.1.3.4
additional information
LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, LPP-3 is involved in embryonal axis patterning, overview
665805
Homo sapiens
?
-
-
-
-
3.1.3.4
additional information
LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, overview
665805
Mus musculus
?
-
-
-
-
3.1.3.4
additional information
LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, overview
665805
Rattus norvegicus
?
-
-
-
-
3.1.3.4
additional information
LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, overview
665805
Homo sapiens
?
-
-
-
-
3.1.3.4
additional information
LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, Wunen and Wunen2 are essential for germ cell development, overview
665805
Drosophila melanogaster
?
-
-
-
-
3.1.3.4
additional information
LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, overview, expression of PRG-1 in neurons increases extracellular lysophosphatidic acid breakdown and attenuates LPA-induced axonal retraction, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, overview
665805
Homo sapiens
?
-
-
-
-
3.1.3.4
additional information
Wunen does not interact with Wunen2
665805
Drosophila melanogaster
?
-
-
-
-
3.1.3.4
phosphatidic acid + H2O
-
665805
Drosophila melanogaster
diacylglycerol + phosphate
-
-
-
?
3.1.3.4
phosphatidic acid + H2O
-
665805
Mus musculus
diacylglycerol + phosphate
-
-
-
?
3.1.3.4
phosphatidic acid + H2O
-
665805
Rattus norvegicus
diacylglycerol + phosphate
-
-
-
?
3.1.3.4
phosphatidic acid + H2O
-
665805
Homo sapiens
diacylglycerol + phosphate
-
-
-
?
3.1.3.4
sphingosine 1-phosphate + H2O
-
665805
Drosophila melanogaster
sphingosine + phosphate
-
-
-
?
3.1.3.4
sphingosine 1-phosphate + H2O
-
665805
Mus musculus
sphingosine + phosphate
-
-
-
?
3.1.3.4
sphingosine 1-phosphate + H2O
-
665805
Rattus norvegicus
sphingosine + phosphate
-
-
-
?
3.1.3.4
sphingosine 1-phosphate + H2O
-
665805
Homo sapiens
sphingosine + phosphate
-
-
-
?
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
3.1.3.4
More
the LPPs contain three conserved active site domains and six conserved transmembrane domains
Drosophila melanogaster