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Literature summary extracted from

  • Du, J.; Cai, S.; Suzuki, H.; Akhand, A.A.; Ma, X.; Takagi, Y.; Miyata, T.; Nakashima, I.; Nagase, F.
    Involvement of MEKK1/ERK/p21Waf1/Cip1 signal transduction pathway in inhibition of IGF-I-mediated cell growth response by methylglyoxal (2003), J. Cell. Biochem., 88, 1235-1246.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.25 methylglyoxal induces the PI3K/PKC/Raf-1-independent MEK/ERK signaling pathway by activation of MEKK1, accumulates in case of diabetes Mus musculus
2.7.11.25 methylglyoxal induces the PI3K/PKC/Raf-1-independent MEK/ERK signaling pathway by activation of MEKK1, accumulates in case of diabetes Homo sapiens
2.7.11.25 additional information no effect on enzyme activity by RAF-1 Mus musculus
2.7.11.25 additional information no effect on enzyme activity by RAF-1 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.25 additional information no inhibition by LY294002 or bisindolylmaleimide Homo sapiens
2.7.11.25 additional information no inhibition by LY294002 or bisindolylmaleimide Mus musculus
2.7.11.25 PD98059
-
 Homo sapiens
2.7.11.25 PD98059
-
 Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.25 Mg2+
-
 Mus musculus
2.7.11.25 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.25 ATP + ERK Mus musculus PI3K/PKC/Raf-1-independent activation of the MEK/ERK signaling pathway ADP + phosphorylated ERK
-
 ?
2.7.11.25 ATP + ERK Homo sapiens PI3K/PKC/Raf-1-independent activation of the MEK/ERK signaling pathway ADP + phosphorylated ERK
-
 ?
2.7.11.25 ATP + MEK Mus musculus PI3K/PKC/Raf-1-independent activation of the MEK/ERK signaling pathway ADP + phosphorylated MEK
-
 ?
2.7.11.25 ATP + MEK Homo sapiens PI3K/PKC/Raf-1-independent activation of the MEK/ERK signaling pathway ADP + phosphorylated MEK
-
 ?
2.7.11.25 additional information Mus musculus alterations of the intracellular milieu induced by methylglyoxal through a MEKK1-mediated and PI3K/PKC/Raf-1-independent pathway results in the modification of cell response to IGF-I for the cyclin-dependent kinase inhibitor p21Waf1/Cip1-mediated growth arrest ?
-
 ?
2.7.11.25 additional information Homo sapiens alterations of the intracellular milieu induced by methylglyoxal through a MEKK1-mediated and PI3K/PKC/Raf-1-independent pathway results in the modification of cell response to IGF-I for the cyclin-dependent kinase inhibitor p21_Waf1/Cip1-mediated growth arrest, which may be one of the crucial mechanisms for methylglyoxal to promote the development of chronic clinical complications in diabetes in humans ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.25 Homo sapiens
-
-
-
2.7.11.25 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.25 HEK-293 cell embryonic kidney cell line Homo sapiens
-
2.7.11.25 NIH-3T3 cell fibroblast cell line Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.25 ATP + ERK
-
 Mus musculus ADP + phosphorylated ERK
-
 ?
2.7.11.25 ATP + ERK
-
 Homo sapiens ADP + phosphorylated ERK
-
 ?
2.7.11.25 ATP + ERK PI3K/PKC/Raf-1-independent activation of the MEK/ERK signaling pathway Mus musculus ADP + phosphorylated ERK
-
 ?
2.7.11.25 ATP + ERK PI3K/PKC/Raf-1-independent activation of the MEK/ERK signaling pathway Homo sapiens ADP + phosphorylated ERK
-
 ?
2.7.11.25 ATP + MEK
-
 Mus musculus ADP + phosphorylated MEK
-
 ?
2.7.11.25 ATP + MEK
-
 Homo sapiens ADP + phosphorylated MEK
-
 ?
2.7.11.25 ATP + MEK PI3K/PKC/Raf-1-independent activation of the MEK/ERK signaling pathway Mus musculus ADP + phosphorylated MEK
-
 ?
2.7.11.25 ATP + MEK PI3K/PKC/Raf-1-independent activation of the MEK/ERK signaling pathway Homo sapiens ADP + phosphorylated MEK
-
 ?
2.7.11.25 ATP + MKK4 a MAPKK Mus musculus ADP + phosphorylated MKK4
-
 ?
2.7.11.25 ATP + MKK4 a MAPKK Homo sapiens ADP + phosphorylated MKK4
-
 ?
2.7.11.25 additional information alterations of the intracellular milieu induced by methylglyoxal through a MEKK1-mediated and PI3K/PKC/Raf-1-independent pathway results in the modification of cell response to IGF-I for the cyclin-dependent kinase inhibitor p21Waf1/Cip1-mediated growth arrest Mus musculus ?
-
 ?
2.7.11.25 additional information alterations of the intracellular milieu induced by methylglyoxal through a MEKK1-mediated and PI3K/PKC/Raf-1-independent pathway results in the modification of cell response to IGF-I for the cyclin-dependent kinase inhibitor p21_Waf1/Cip1-mediated growth arrest, which may be one of the crucial mechanisms for methylglyoxal to promote the development of chronic clinical complications in diabetes in humans Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.25 MEK kinase 1
-
 Mus musculus
2.7.11.25 MEK kinase 1
-
 Homo sapiens
2.7.11.25 MEKK1
-
 Mus musculus
2.7.11.25 MEKK1
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.25 30
-
 assay at Mus musculus
2.7.11.25 30
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.25 7.4
-
 assay at Mus musculus
2.7.11.25 7.4
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.25 ATP
-
 Mus musculus
2.7.11.25 ATP
-
 Homo sapiens