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Literature summary extracted from

  • Jansen, S.; Stefan, C.; Creemers, J.W.; Waelkens, E.; Van Eynde, A.; Stalmans, W.; Bollen, M.
    Proteolytic maturation and activation of autotaxin (NPP2), a secreted metastasis-enhancing lysophospholipase D (2005), J. Cell Sci., 118, 3081-3089.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.4.39 medicine stimulates cell proliferation, cell motility and angiogenesis Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.39 expression in Escherichia coli DH5alpha Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.39 extracellular
-
 Rattus norvegicus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.4.39 120000
-
 immunoblotting, lysate and medium Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.39 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.4.39 proteolytic modification proteolytically processed protein is secreted, secreted and cell-associated NPP2 are differently glycosylated Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.39 lysophosphatidylcholine + H2O
-
 Rattus norvegicus lysophosphatidic acid + choline
-
 ?
3.1.4.39 sphingosylphosphorylcholine + H2O
-
 Rattus norvegicus sphingosine-1-phosphate + choline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.39 ATX
-
 Rattus norvegicus
3.1.4.39 autotaxin
-
 Rattus norvegicus
3.1.4.39 NPP2
-
 Rattus norvegicus