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Literature summary extracted from

  • Oka, S.; Kato, J.; Moss, J.
    Identification and characterization of a mammalian 39-kDa poly(ADP-ribose) glycohydrolase (2006), J. Biol. Chem., 281, 705-713.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.2.1.143 dithiothreitol activation Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.2.1.143 D77N/D78N no enzymic activity, binding of ADP-ribose is similar to wild-type Mus musculus
3.2.1.143 E238Q/E239Q catalytic activity similar to wild-type Mus musculus
3.2.1.143 E261Q/E262Q catalytic activity similar to wild-type Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.2.1.143 cytosol
-
 Mus musculus 5829
-
3.2.1.143 cytosol
-
 Homo sapiens 5829
-
3.2.1.143 nucleus
-
 Mus musculus 5634
-
3.2.1.143 nucleus
-
 Homo sapiens 5634
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.2.1.143 MgCl2 10 mM, activation Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.2.1.143 39000
-
 x * 39000, SDS-PAGE Mus musculus
3.2.1.143 39000
-
 x * 39000, SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.143 Homo sapiens Q9NX46
-
-
3.2.1.143 Mus musculus Q8CG72
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.143 brain high abundance Mus musculus
-
3.2.1.143 liver high abundance Mus musculus
-
3.2.1.143 additional information present in all tissues tested Mus musculus
-
3.2.1.143 ovary high abundance Mus musculus
-
3.2.1.143 spleen high abundance Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.143 additional information no substrate: mono-ADP-ribosylated proteins, ADP-ribose-arginine, ADP-ribose-cysteine, ADP-ribose-diphthaminde, ADP-ribose-asparagine Mus musculus ?
-
 ?
3.2.1.143 poly(ADP-ribose)n + H2O
-
 Mus musculus ADP-ribose and lower molecular weight poly(ADP-ribose)n fragment products, no product: phosphoribosyl-AMP ?
3.2.1.143 poly(ADP-ribose)n + H2O
-
 Homo sapiens ADP-ribose and lower molecular weight poly(ADP-ribose)n fragment products, no product: phosphoribosyl-AMP ?
3.2.1.143 poly(ADP-ribose)n-poly(ADP-ribose) polymerase + H2O
-
 Homo sapiens ADP-ribose + poly(ADP-ribose) polymerase
-
 ?

Subunits

EC Number Subunits Comment Organism
3.2.1.143 ? x * 39000, SDS-PAGE Mus musculus
3.2.1.143 ? x * 39000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.2.1.143 ARH3
-
 Mus musculus
3.2.1.143 ARH3
-
 Homo sapiens