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Literature summary extracted from

  • Tsui, J.; Inagaki, M.; Schulman, H.
    Calcium/calmodulin-dependent protein kinase II (CaMKII) localization acts in concert with substrate targeting to create spatial restriction for phosphorylation (2005), J. Biol. Chem., 280, 9210-9216.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.17 Calmodulin dependent on Homo sapiens
2.7.11.17 ionomycin activates both the wild-type and mutant I205K CaMKII Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.17 functional cytoplasmic co-expression of wild-type CaMKII with vimentin-NR2B, a construct of a vimentin peptide containing Ser82 fused to the NMDA receptor 2B subunit, an interaction partner of CaMKII, in HEK-293 cells, translocation of the Vin-NR2B construct to the membrane is regulated by lipid rafts resulting in reduced phosphorylation by CaMKII Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.17 I205K site-directed mutagenesis, the mutant CaMKII shows reduced activity with vimentin compared to the wild-type enzyme Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.17 BAPTA-AM
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.17 cytoplasm
-
 Homo sapiens 5737
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.17 Ca2+ dependent on Homo sapiens
2.7.11.17 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.17 ATP + vimentin Homo sapiens specific phosphorylation by CaMKII at Ser82 ADP + phosphorylated vimentin
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.17 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.17 brain
-
 Homo sapiens
-
2.7.11.17 HEK-293 cell
-
 Homo sapiens
-
2.7.11.17 neuron
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.17 ATP + vimentin specific phosphorylation by CaMKII at Ser82 Homo sapiens ADP + phosphorylated vimentin
-
 ?
2.7.11.17 ATP + vimentin specific phosphorylation by CaMKII at Ser82, wild-type vimentin protein and a construct of a vimentin peptide containing Ser82 fused to the NMDA receptor 2B subunit, an interaction partner of CaMKII Homo sapiens ADP + phosphorylated vimentin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.17 calcium/calmodulin-dependent protein kinase II
-
 Homo sapiens
2.7.11.17 CaMKII
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.17 ATP
-
 Homo sapiens