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Literature summary extracted from

  • Robison, A.J.; Bass, M.A.; Jiao, Y.; MacMillan, L.B.; Carmody, L.C.; Bartlett, R.K.; Colbran, R.J.
    Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2 (2005), J. Biol. Chem., 280, 35329-35336.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.17 Calmodulin dependent on Mus musculus
2.7.11.17 Calmodulin dependent on Rattus norvegicus
2.7.11.17 Calmodulin dependent on Sus scrofa
2.7.11.17 Calmodulin dependent on Xenopus laevis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.17 synapse dendritic CaMKII is dynamically targeted to the synapse Rattus norvegicus 45202
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.17 Ca2+ dependent on Mus musculus
2.7.11.17 Ca2+ dependent on Rattus norvegicus
2.7.11.17 Ca2+ dependent on Sus scrofa
2.7.11.17 Ca2+ dependent on Xenopus laevis
2.7.11.17 Mg2+
-
 Mus musculus
2.7.11.17 Mg2+
-
 Rattus norvegicus
2.7.11.17 Mg2+
-
 Sus scrofa
2.7.11.17 Mg2+
-
 Xenopus laevis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.17 additional information Mus musculus Thr286-autophosphorylated CaMKII is associated with CaMKII-binding proteins densin-180, the N-methyl-D-aspartate receptor NR2B subunit, and alpha-actinin-2 in postsynaptic density-enriched rat brain fractions, the proteins influence each other in binding to CaMKII, interaction of binding proteins with CaMKII splicing variants, overview ?
-
 ?
2.7.11.17 additional information Rattus norvegicus Thr286-autophosphorylated CaMKII is associated with CaMKII-binding proteins densin-180, the N-methyl-D-aspartate receptor NR2B subunit, and alpha-actinin-2 in postsynaptic density-enriched rat brain fractions, the proteins influence each other in binding to CaMKII, interaction of binding proteins with CaMKII splicing variants, overview ?
-
 ?
2.7.11.17 additional information Sus scrofa Thr286-autophosphorylated CaMKII is associated with CaMKII-binding proteins densin-180, the N-methyl-D-aspartate receptor NR2B subunit, and alpha-actinin-2 in postsynaptic density-enriched rat brain fractions, the proteins influence each other in binding to CaMKII, interaction of binding proteins with CaMKII splicing variants, overview ?
-
 ?
2.7.11.17 additional information Xenopus laevis Thr286-autophosphorylated CaMKII is associated with CaMKII-binding proteins densin-180, the N-methyl-D-aspartate receptor NR2B subunit, and alpha-actinin-2 in postsynaptic density-enriched rat brain fractions, the proteins influence each other in binding to CaMKII, interaction of binding proteins with CaMKII splicing variants, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.17 Mus musculus
-
 isozyme CaMKIIalpha
-
2.7.11.17 Rattus norvegicus
-
 isozyme CaMKIIalpha
-
2.7.11.17 Sus scrofa
-
 isozyme CaMKIIgammaB
-
2.7.11.17 Xenopus laevis
-
 isozyme CaMKIIbeta
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.17 phosphoprotein isozyme CaMKIIalpha is autophosphorylated at Thr286 and Thr287 which allows it to bind to the C-terminal CaMKII-binding site at residues 819-894 of alpha-actinin-2, to residues 1260-1339 of receptor subunit NR2B, or to residues 1247-1495 of densin-180, overview Mus musculus
2.7.11.17 phosphoprotein isozyme CaMKIIalpha is autophosphorylated at Thr286 and Thr287 which allows it to bind to the C-terminal CaMKII-binding site at residues 819-894 of alpha-actinin-2, to residues 1260-1339 of receptor subunit NR2B, or to residues 1247-1495 of densin-180, overview Rattus norvegicus
2.7.11.17 phosphoprotein isozyme CaMKIIalpha is autophosphorylated at Thr286 and Thr287 which allows it to bind to the C-terminal CaMKII-binding site at residues 819-894 of alpha-actinin-2, to residues 1260-1339 of receptor subunit NR2B, or to residues 1247-1495 of densin-180, overview Sus scrofa
2.7.11.17 phosphoprotein isozyme CaMKIIalpha is autophosphorylated at Thr286 and Thr287 which allows it to bind to the C-terminal CaMKII-binding site at residues 819-894 of alpha-actinin-2, to residues 1260-1339 of receptor subunit NR2B, or to residues 1247-1495 of densin-180, overview Xenopus laevis

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.17 forebrain
-
 Rattus norvegicus
-
2.7.11.17 additional information CaMKIIalpha is associated with CaMKII-binding proteins densin-180, the N-methyl-D-aspartate receptor NR2B subunit, and alpha-actinin-2 in postsynaptic density-enriched rat brain fractions Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.17 additional information Thr286-autophosphorylated CaMKII is associated with CaMKII-binding proteins densin-180, the N-methyl-D-aspartate receptor NR2B subunit, and alpha-actinin-2 in postsynaptic density-enriched rat brain fractions, the proteins influence each other in binding to CaMKII, interaction of binding proteins with CaMKII splicing variants, overview Mus musculus ?
-
 ?
2.7.11.17 additional information Thr286-autophosphorylated CaMKII is associated with CaMKII-binding proteins densin-180, the N-methyl-D-aspartate receptor NR2B subunit, and alpha-actinin-2 in postsynaptic density-enriched rat brain fractions, the proteins influence each other in binding to CaMKII, interaction of binding proteins with CaMKII splicing variants, overview Rattus norvegicus ?
-
 ?
2.7.11.17 additional information Thr286-autophosphorylated CaMKII is associated with CaMKII-binding proteins densin-180, the N-methyl-D-aspartate receptor NR2B subunit, and alpha-actinin-2 in postsynaptic density-enriched rat brain fractions, the proteins influence each other in binding to CaMKII, interaction of binding proteins with CaMKII splicing variants, overview Sus scrofa ?
-
 ?
2.7.11.17 additional information Thr286-autophosphorylated CaMKII is associated with CaMKII-binding proteins densin-180, the N-methyl-D-aspartate receptor NR2B subunit, and alpha-actinin-2 in postsynaptic density-enriched rat brain fractions, the proteins influence each other in binding to CaMKII, interaction of binding proteins with CaMKII splicing variants, overview Xenopus laevis ?
-
 ?
2.7.11.17 additional information isozyme-selective CaMKII binding sequence for interaction with ligand proteins, overview Mus musculus ?
-
 ?
2.7.11.17 additional information isozyme-selective CaMKII binding sequence for interaction with ligand proteins, overview Rattus norvegicus ?
-
 ?
2.7.11.17 additional information isozyme-selective CaMKII binding sequence for interaction with ligand proteins, overview Sus scrofa ?
-
 ?
2.7.11.17 additional information isozyme-selective CaMKII binding sequence for interaction with ligand proteins, overview Xenopus laevis ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.17 calcium/calmodulin-dependent protein kinase II
-
 Mus musculus
2.7.11.17 calcium/calmodulin-dependent protein kinase II
-
 Rattus norvegicus
2.7.11.17 calcium/calmodulin-dependent protein kinase II
-
 Sus scrofa
2.7.11.17 calcium/calmodulin-dependent protein kinase IIbeta
-
 Xenopus laevis
2.7.11.17 CaMKIIalpha
-
 Mus musculus
2.7.11.17 CaMKIIalpha
-
 Rattus norvegicus
2.7.11.17 CaMKIIbeta
-
 Xenopus laevis
2.7.11.17 CaMKIIgammaB
-
 Sus scrofa

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.17 30
-
 assay at Mus musculus
2.7.11.17 30
-
 assay at Rattus norvegicus
2.7.11.17 30
-
 assay at Sus scrofa
2.7.11.17 30
-
 assay at Xenopus laevis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.17 7.5
-
 assay at Mus musculus
2.7.11.17 7.5
-
 assay at Rattus norvegicus
2.7.11.17 7.5
-
 assay at Sus scrofa
2.7.11.17 7.5
-
 assay at Xenopus laevis

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.17 ATP
-
 Mus musculus
2.7.11.17 ATP
-
 Rattus norvegicus
2.7.11.17 ATP
-
 Sus scrofa
2.7.11.17 ATP
-
 Xenopus laevis