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Literature summary extracted from

  • Urbaniak, M.D.; Crossman, A.; Chang, T.; Smith, T.K.; van Aalten, D.M.; Ferguson, M.A.
    The N-acetyl-D-glucosaminylphosphatidylinositol De-N-acetylase of glycosylphosphatidylinositol biosynthesis is a zinc metalloenzyme (2005), J. Biol. Chem., 280, 22831-22838.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.5.1.89 additional information a tightly bound divalent metal cation is essential for activity Trypanosoma brucei
3.5.1.89 additional information a tightly bound divalent metal cation is essential for activity Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.5.1.89 expression in Escherichia coli Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.5.1.89 membrane
-
 Trypanosoma brucei 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.5.1.89 Co2+ can replace Zn2+ Trypanosoma brucei
3.5.1.89 Co2+ can replace Zn2+ Rattus norvegicus
3.5.1.89 Cu2+ can replace Zn2+ Trypanosoma brucei
3.5.1.89 Cu2+ can replace Zn2+ Rattus norvegicus
3.5.1.89 Mg2+ can replace Zn2+ Trypanosoma brucei
3.5.1.89 Mg2+ can replace Zn2+ Rattus norvegicus
3.5.1.89 Ni2+ can replace Zn2+ Trypanosoma brucei
3.5.1.89 Ni2+ can replace Zn2+ Rattus norvegicus
3.5.1.89 Zn2+ essential for activity Trypanosoma brucei
3.5.1.89 Zn2+ essential for activity Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.89 Rattus norvegicus O35790
-
-
3.5.1.89 Trypanosoma brucei Q382X3
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.89 N-Acetyl-D-glucosaminylphosphatidylinositol + H2O 30°C, pH 7.4, 50 mM KCl, 10 mM dithiothreitol, 0.1 mM 1-chloro-3-tosylamido-7-amino-2-heptanone, 1 microg/ml leupeptin Trypanosoma brucei D-Glucosaminylphosphatidylinositol + acetate
-
 ?
3.5.1.89 N-Acetyl-D-glucosaminylphosphatidylinositol + H2O 37°C Rattus norvegicus D-Glucosaminylphosphatidylinositol + acetate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.89 GlcNAc-PI de-N-acetylase
-
 Trypanosoma brucei
3.5.1.89 GlcNAc-PI de-N-acetylase
-
 Rattus norvegicus
3.5.1.89 N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase
-
 Trypanosoma brucei
3.5.1.89 N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase
-
 Rattus norvegicus