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Literature summary extracted from

  • Vijayan, K.V.; Liu, Y.; Sun, W.; Ito, M.; Bray, P.F.
    The Pro33 isoform of integrin beta3 enhances outside-in signaling in human platelets by regulating the activation of serine/threonine phosphatases (2005), J. Biol. Chem., 280, 21756-21762.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.16 okadaic acid
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.16 additional information Homo sapiens the Pro33 isoform of integrin beta3 enhances outside-in signaling in platelets by regulating the activation of serine/threonine phosphatases ?
-
 ?
3.1.3.16 phosphorylated ERK2 + H2O Homo sapiens
-
 ERK2 + phosphate
-
 ?
3.1.3.16 phosphorylated myosin light chain + H2O Homo sapiens dephosphorylation at Thr696 myosin light chain + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.16 Homo sapiens
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.1.3.16 [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate the enzyme also performs the reaction of EC 3.1.3.53, myosin-light-chain-phosphatase Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.16 blood platelet Pro33-isozyme positive platelets show increased MLC and ERK phosphorylation and reduced protein phosphatase activity, and vice versa in Pro33-isozyme negative platelets, overview Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.16 additional information the Pro33 isoform of integrin beta3 enhances outside-in signaling in platelets by regulating the activation of serine/threonine phosphatases Homo sapiens ?
-
 ?
3.1.3.16 phosphorylated ERK2 + H2O
-
 Homo sapiens ERK2 + phosphate
-
 ?
3.1.3.16 phosphorylated myosin light chain + H2O dephosphorylation at Thr696 Homo sapiens myosin light chain + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.16 More EC 3.1.3.53, myosin-light-chain-phosphatase Homo sapiens
3.1.3.16 serine/threonine phosphatase
-
 Homo sapiens