Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • van Meeteren, L.A.; Ruurs, P.; Christodoulou, E.; Goding, J.W.; Takakusa, H.; Kikuchi, K.; Perrakis, A.; Nagano, T.; Moolenaar, W.H.
    Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate (2005), J. Biol. Chem., 280, 21155-21161.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.4.39 medicine promotes tumor cell motility, experimental metastasis, and angiogenesis Streptomyces chromofuscus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.39 expression in Bac-to-Bac baculovirus in Sf9 insect cells Streptomyces chromofuscus

Protein Variants

EC Number Protein Variants Comment Organism
3.1.4.39 T210A inactive mutant Streptomyces chromofuscus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.39 1-myristoyl-lysophosphatidic acid
-
 Streptomyces chromofuscus
3.1.4.39 1-oleoyl-lysophosphatidic acid
-
 Streptomyces chromofuscus
3.1.4.39 1-palmitoyl-lysophosphatidic acid
-
 Streptomyces chromofuscus
3.1.4.39 bis(para-nitrophenyl)phosphate inhibition above a concentration of 1 mM Streptomyces chromofuscus
3.1.4.39 lysophosphatidic acid 0.001 mM, complexed to albumin, competitive and noncompetitive components Streptomyces chromofuscus
3.1.4.39 additional information not affected by dioleoylphosphatidic acid, 1-oleoyl-glycerol, sphingosine, glycerol 3-phosphate Streptomyces chromofuscus
3.1.4.39 sphingosine-1-phosphate 0.001 mM, complexed to albumin Streptomyces chromofuscus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.4.39 0.15
-
 lysophosphatidylcholine
-
 Streptomyces chromofuscus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.39 cytoplasmic vesicle
-
 Streptomyces chromofuscus 31410
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.4.39 125000
-
 SDS-PAGE Streptomyces chromofuscus

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.39 Streptomyces chromofuscus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.39 4-nitrophenyl thymidine 5'-phosphate + H2O
-
 Streptomyces chromofuscus 4-nitrophenol + thymidine 5'-phosphate
-
 ?
3.1.4.39 bis(para-nitrophenyl)phosphate + H2O
-
 Streptomyces chromofuscus ?
-
 ?
3.1.4.39 CPF4 + H2O bis-pNPP-derived probe, in which both phenyl moieties are linked to coumarin and fluorescein, respectively Streptomyces chromofuscus ?
-
 ?
3.1.4.39 lysophosphatidylcholine + H2O
-
 Streptomyces chromofuscus lysophosphatidic acid + choline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.39 ATX
-
 Streptomyces chromofuscus
3.1.4.39 autotaxin
-
 Streptomyces chromofuscus
3.1.4.39 NPP2
-
 Streptomyces chromofuscus
3.1.4.39 PLD
-
 Streptomyces chromofuscus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.4.39 0.00011
-
 lysophosphatidic acid
-
 Streptomyces chromofuscus