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Literature summary extracted from

  • Chen, X.; Jhee, K.H.; Kruger, W.D.
    Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine (2004), J. Biol. Chem., 279, 52082-52086.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.1.22 expression in yeast or in Escherichia coli Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.2.1.22 1.74
-
 L-serine pH 8.6 Homo sapiens
4.2.1.22 6.11
-
 L-cysteine pH 8.6 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.22 Homo sapiens
-
 recombinant
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.22 L-Cysteine + DL-homocysteine full-length enzyme and truncated enzyme form lacking the C-terminal regulatory domain Homo sapiens Cystathionine + H2S
-
 ?
4.2.1.22 L-Serine + homocysteine
-
 Homo sapiens Cystathionine + H2O
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.2.1.22 3.13
-
 L-cysteine pH 8.6 Homo sapiens
4.2.1.22 4.39
-
 L-cysteine pH 8.6 Homo sapiens
4.2.1.22 10.2
-
 L-serine pH 8.6 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
4.2.1.22 S-adenosyl-L-methionine stimulates Homo sapiens