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Literature summary extracted from

  • Takemoto-Kimura, S.; Terai, H.; Takamoto, M.; Ohmae, S.; Kikumura, S.; Segi, E.; Arakawa, Y.; Furuyashiki, T.; Narumiya, S.; Bito, H.
    Molecular cloning and characterization of CLICK-III/CaMKIg, a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase (CaMK) (2003), J. Biol. Chem., 278, 18597-18605.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.17 Calmodulin dependent on, the Ca2+/calmodulin-binding domain overlaps with the autoinhibition domain Homo sapiens
2.7.11.17 Calmodulin dependent on, the Ca2+/calmodulin-binding domain overlaps with the autoinhibition domain Mus musculus
2.7.11.17 additional information Thr178 is localized in the activation loop Homo sapiens
2.7.11.17 additional information Thr178 is localized in the activation loop Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.17 CaMKIgamma, DNA and amino acid sequence determination and analysis, expression as GFT-tagged protein in COS-7 cells with localization in the Golgi apparatus and the plasma membrane Mus musculus
2.7.11.17 CaMKIgamma, DNA and amino acid sequence determination and analysis, expression in COS-7 cells Homo sapiens
2.7.11.17 expression of CaMKIalpha in COS-7 cells with localization in the Golgi apparatus and the plasma membrane Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.17 additional information the Ca2+/calmodulin-binding domain overlaps with the autoinhibition domain Homo sapiens
2.7.11.17 additional information the Ca2+/calmodulin-binding domain overlaps with the autoinhibition domain Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.17 Golgi membrane
-
 Mus musculus 139
-
2.7.11.17 membrane anchored Homo sapiens 16020
-
2.7.11.17 membrane anchored Mus musculus 16020
-
2.7.11.17 plasma membrane
-
 Mus musculus 5886
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.17 Ca2+ dependent on, activates, the Ca2+/calmodulin-binding domain overlaps with the autoinhibition domain Homo sapiens
2.7.11.17 Ca2+ dependent on, activates, the Ca2+/calmodulin-binding domain overlaps with the autoinhibition domain Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.17 Homo sapiens Q96NX5 CaMKIgamma; isozyme CaMKIgamma or CLICK-III
-
2.7.11.17 Mus musculus Q91VB2 CaMKIgamma
-
2.7.11.17 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.17 brain
-
 Rattus norvegicus
-
2.7.11.17 brain isozyme CaMKIgamma, high expression level Homo sapiens
-
2.7.11.17 brain isozyme CaMKIgamma, high expression level Mus musculus
-
2.7.11.17 hippocampus
-
 Homo sapiens
-
2.7.11.17 hippocampus
-
 Mus musculus
-
2.7.11.17 neuron CA1 and CA3 hippocampal neurons Homo sapiens
-
2.7.11.17 neuron CA1 and CA3 hippocampal neurons Mus musculus
-

Synonyms

EC Number Synonyms Comment Organism
2.7.11.17 calcium/calmodulin-dependent protein kinase 1G
-
 Homo sapiens
2.7.11.17 calcium/calmodulin-dependent protein kinase 1G
-
 Mus musculus
2.7.11.17 CaM kinase IG
-
 Homo sapiens
2.7.11.17 CaM kinase IG
-
 Mus musculus
2.7.11.17 CaMK-like CREB kinase-III
-
 Homo sapiens
2.7.11.17 CaMK-like CREB kinase-III
-
 Mus musculus
2.7.11.17 CaMKIalpha
-
 Rattus norvegicus
2.7.11.17 CaMKIG
-
 Homo sapiens
2.7.11.17 CaMKIG
-
 Mus musculus
2.7.11.17 CaMKIgamma
-
 Homo sapiens
2.7.11.17 CaMKIgamma
-
 Mus musculus
2.7.11.17 CLICK-III
-
 Homo sapiens
2.7.11.17 CLICK-III
-
 Mus musculus
2.7.11.17 More CLICK-III belongs to the CaMKI family Homo sapiens
2.7.11.17 More CLICK-III belongs to the CaMKI family Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.17 ATP
-
 Homo sapiens
2.7.11.17 ATP
-
 Mus musculus