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Literature summary extracted from

  • Kashii, T.; Gomi, T.; Oya, T.; Ishii, Y.; Oda, H.; Maruyama, M.; Kobayashi, M.; Masuda, T.; Yamazaki, M.; Nagata, T.; Tsukada, K.; Nakajima, A.; Tatsu, K.; Mori, H.; Takusagawa, F.; Ogawa, H.; Pitot, H.C.
    Some biochemical and histochemical properties of human liver serine dehydratase (2005), Int. J. Biochem. Cell Biol., 37, 574-589.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.3.1.17 45
-
 L-serine pH 8.3, 37°C Rattus norvegicus
4.3.1.17 50
-
 L-serine pH 8.3, 37°C Homo sapiens
4.3.1.17 57
-
 L-threonine pH 8.3, 37°C Rattus norvegicus
4.3.1.17 57
-
 L-threonine pH 8.3, 37°C Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.3.1.17 33000
-
 2 * 33000, SDS-PAGE, 2 * 34702, calculated Homo sapiens
4.3.1.17 34702
-
 2 * 33000, SDS-PAGE, 2 * 34702, calculated Homo sapiens
4.3.1.17 60000
-
 gel filtration Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
4.3.1.17 Homo sapiens P20132
-
-
4.3.1.17 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.3.1.17 recombinant protein expressed in Escherichia coli Rattus norvegicus
4.3.1.17 recombinant protein expressed in Escherichia coli Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.3.1.17 liver confined to periportal region Rattus norvegicus
-
4.3.1.17 liver predominantly localized in perivenous region Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.3.1.17 96
-
 substrate L-threonine, pH 8.3, 37°C Homo sapiens
4.3.1.17 116
-
 substrate L-threonine, pH 8.3, 37°C Rattus norvegicus
4.3.1.17 137
-
 substrate L-serine, pH 8.3, 37°C Homo sapiens
4.3.1.17 200
-
 substrate L-serine, pH 8.3, 37°C Rattus norvegicus

Storage Stability

EC Number Storage Stability Organism
4.3.1.17 -80°C, stable for more than 2 weeks Homo sapiens
4.3.1.17 0°C, stable for at least 2 weeks Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.3.1.17 L-serine
-
 Rattus norvegicus pyruvate + NH3
-
 ?
4.3.1.17 L-serine
-
 Homo sapiens pyruvate + NH3
-
 ?
4.3.1.17 L-threonine
-
 Rattus norvegicus 2-oxobutyrate + NH3
-
 ?
4.3.1.17 L-threonine
-
 Homo sapiens 2-oxobutyrate + NH3
-
 ?

Subunits

EC Number Subunits Comment Organism
4.3.1.17 dimer 2 * 33000, SDS-PAGE, 2 * 34702, calculated Homo sapiens