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Literature summary extracted from

  • Ejim, L.J.; D'Costa, V.M.; Elowe, N.H.; Loredo-Osti, J.C.; Malo, D.; Wright, G.D.
    Cystathionine beta-lyase is important for virulence of Salmonella enterica serovar Typhimurium (2004), Infect. Immun., 72, 3310-3314.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
4.4.1.13 medicine the enzyme is important for bacterial virulence and is therefor a potential target for antibacterial drug development Salmonella enterica

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.4.1.13 additional information the enzyme is not inhibited by pyridamine antimicrobial agents (pyrimethanil, cyprodinil or mepanipyrim) Salmonella enterica

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.4.1.13 0.38
-
cystathionine
-
Salmonella enterica

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.4.1.13 additional information Salmonella enterica the enzyme catalyzes the penultimate step in methionine biosynthesis. The enzyme is important for bacterial virulence ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.13 Salmonella enterica
-
serovar typhimurium
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.13 cystathionine + H2O
-
Salmonella enterica L-homocysteine + NH3 + pyruvate
-
?
4.4.1.13 additional information the enzyme catalyzes the penultimate step in methionine biosynthesis. The enzyme is important for bacterial virulence Salmonella enterica ?
-
?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.4.1.13 1.5
-
cystathionine
-
Salmonella enterica