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Literature summary extracted from

  • Straeter, N.; Lipscomb, W.N.
    Leucine aminopeptidase (2004), Handbook of Metalloproteins (Messerschmidt, A. ; Huber, R. ; Wieghardt, K. ; Palos, T. , eds. ), 3, 199-207.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.11.10 bicarbonate activates Escherichia coli

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.4.11.10 crystallization at pH 8.0 of enzyme in high salt Tris buffer against low salt concentration, X-ray diffraction crystal structure determination and analysis at 2.5 A resolution Escherichia coli

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.11.10 Zn2+ metallopeptidase, dimetal site structure, overview Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.11.10 additional information Escherichia coli PepA acts as DNA-binding protein in Xer site-specific DNA recombination serving as accessory protein ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.10 Escherichia coli
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.4.11.10 Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids. catalytic mechanism Escherichia coli
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.10 L-Leu-4-nitroanilide + H2O
-
 Escherichia coli L-Leu + 4-nitroaniline
-
 ?
3.4.11.10 additional information PepA acts as DNA-binding protein in Xer site-specific DNA recombination serving as accessory protein Escherichia coli ?
-
 ?
3.4.11.10 additional information PepA binds DNA probably along the large groove that runs from the lower trimer face across the twofold molecular axis to the upper trimer face Escherichia coli ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.11.10 hexamer lens enzyme three-dimensional structure and protein fold, overview Escherichia coli

Synonyms

EC Number Synonyms Comment Organism
3.4.11.10 LAP
-
 Escherichia coli
3.4.11.10 leucine aminopeptidase
-
 Escherichia coli
3.4.11.10 More the enzyme belongs to the peptidase family M17 Escherichia coli
3.4.11.10 PepA
-
 Escherichia coli