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Literature summary extracted from

  • Nguyen, S.D.; Sok, D.E.
    Effect of 3,4-dihydroxyphenylalanine on Cu2+-induced inactivation of HDL-associated paraoxonase1 and oxidation of HDL; inactivation of paraoxonase1 activity independent of HDL lipid oxidation (2004), Free Radic. Res., 38, 969-976.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.2 butylated hydroxytoluene
-
Homo sapiens
3.1.1.2 Cu2+ oxidizes HDL and inactivates HDL-associated paraoxonase1, relationship, overview, the inactivation is enhanced catecholamines, such as 3,4-dihydroxyphenylalanine, dopamine, or norepinephrine, but not by uric acid or homocysteine, low enhancement of Cu2+-mediated enzyme inactivation by catecholamines caffeic acid and pyrocatechol, and by ascorbate, effects on activity of purified enzyme and HDL-complexed enzyme, overview, the inactivation in prevented by several compounds, e.g. by catalase, ethanol, oleic acid, substrate paraoxon, phenylacetate, and slightly by quercetin, mannitol, and DMSO in presence of 1 mM Ca2+ Homo sapiens
3.1.1.2 EDTA
-
Homo sapiens
3.1.1.2 additional information the enzyme is sensitive to oxidative stress Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.2 extracellular from plasma Homo sapiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.1.2 CaCl2 added to assay Homo sapiens
3.1.1.2 NaCl added to assay Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.2 additional information Homo sapiens the enzyme is one of the HDL-associated antioxidant proteins, overview ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.2 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.2 native enzyme from plasma of fasted humans by sequential chromatographic steps Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.2 blood plasma
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.2 additional information the enzyme is one of the HDL-associated antioxidant proteins, overview Homo sapiens ?
-
?
3.1.1.2 phenyl acetate + H2O
-
Homo sapiens phenol + acetate
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.2 HDL-PON1
-
Homo sapiens
3.1.1.2 paraoxonase1
-
Homo sapiens
3.1.1.2 PON1
-
Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.2 38
-
assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.2 7.4
-
assay at Homo sapiens