Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Rodriguez-Mora, O.; LaHair, M.M.; Howe, C.J.; McCubrey, J.A.; Franklin, R.A.
    Calcium/calmodulin-dependent protein kinases as potential targets in cancer therapy (2005), Expert Opin. Ther. Targets, 9, 791-808.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.17 Calmodulin dependent on Mus musculus
2.7.11.17 Calmodulin dependent on Homo sapiens
2.7.11.17 Calmodulin dependent on Rattus norvegicus
2.7.11.17 additional information redox regulation of CaM-kinases, overview, CaM-KII and CaM-KIV activation mechanisms, overview Mus musculus
2.7.11.17 additional information redox regulation of CaM-kinases, overview, CaM-KII and CaM-KIV activation mechanisms, overview Homo sapiens
2.7.11.17 additional information redox regulation of CaM-kinases, overview, CaM-KII and CaM-KIV activation mechanisms, overview Rattus norvegicus

Application

EC Number Application Comment Organism
2.7.11.17 medicine CaM-kinases act as potential targets in cancer therapy, strategies, overview Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.17 Calmidazolium calmodulin antagonist Homo sapiens
2.7.11.17 Calmidazolium calmodulin antagonist Mus musculus
2.7.11.17 Calmidazolium calmodulin antagonist Rattus norvegicus
2.7.11.17 K252a inhibits CaM-KII Homo sapiens
2.7.11.17 K252a inhibits CaM-KII Mus musculus
2.7.11.17 K252a inhibits CaM-KII Rattus norvegicus
2.7.11.17 KN-62
-
 Homo sapiens
2.7.11.17 KN-62
-
 Mus musculus
2.7.11.17 KN-62
-
 Rattus norvegicus
2.7.11.17 KN-93
-
 Homo sapiens
2.7.11.17 KN-93
-
 Mus musculus
2.7.11.17 KN-93
-
 Rattus norvegicus
2.7.11.17 additional information no inhibition by KN-92, redox regulation of CaM-kinases, inhibition mechanisms, overview Homo sapiens
2.7.11.17 additional information no inhibition by KN-92, redox regulation of CaM-kinases, inhibition mechanisms, overview Mus musculus
2.7.11.17 additional information no inhibition by KN-92, redox regulation of CaM-kinases, inhibition mechanisms, overview Rattus norvegicus
2.7.11.17 trifluoperazine dimaleate calmodulin antagonist Homo sapiens
2.7.11.17 trifluoperazine dimaleate calmodulin antagonist Mus musculus
2.7.11.17 trifluoperazine dimaleate calmodulin antagonist Rattus norvegicus
2.7.11.17 W-13 calmodulin antagonist Homo sapiens
2.7.11.17 W-13 calmodulin antagonist Mus musculus
2.7.11.17 W-13 calmodulin antagonist Rattus norvegicus
2.7.11.17 W-7 calmodulin antagonist Homo sapiens
2.7.11.17 W-7 calmodulin antagonist Mus musculus
2.7.11.17 W-7 calmodulin antagonist Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.17 cytosol CaM-KIV Mus musculus 5829
-
2.7.11.17 cytosol CaM-KIV Homo sapiens 5829
-
2.7.11.17 cytosol CaM-KIV Rattus norvegicus 5829
-
2.7.11.17 nucleus CaM-KIV predominantly Mus musculus 5634
-
2.7.11.17 nucleus CaM-KIV predominantly Homo sapiens 5634
-
2.7.11.17 nucleus CaM-KIV predominantly Rattus norvegicus 5634
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.17 Ca2+ dependent on Mus musculus
2.7.11.17 Ca2+ dependent on Homo sapiens
2.7.11.17 Ca2+ dependent on Rattus norvegicus
2.7.11.17 Mg2+
-
 Mus musculus
2.7.11.17 Mg2+
-
 Homo sapiens
2.7.11.17 Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.17 ATP + I-kappaB Mus musculus substrate of CaM-KII in T-lymphocytes and neurons, phosphorylation leads to activation of I-kappa B, which mediates activation of NF-kappaB ADP + phosphorylated I-kappaB
-
 ?
2.7.11.17 ATP + I-kappaB Homo sapiens substrate of CaM-KII in T-lymphocytes and neurons, phosphorylation leads to activation of I-kappa B, which mediates activation of NF-kappaB ADP + phosphorylated I-kappaB
-
 ?
2.7.11.17 ATP + I-kappaB Rattus norvegicus substrate of CaM-KII in T-lymphocytes and neurons, phosphorylation leads to activation of I-kappa B, which mediates activation of NF-kappaB ADP + phosphorylated I-kappaB
-
 ?
2.7.11.17 additional information Mus musculus CaM-Ks are involved in cell cycle regulation and centrosome replication, as well as in development of cancer via calmodulin activity, overview, CaM-KI is involved in CDK4/cyclin D1 activity in fibroblasts, CaM-KIV induces CREB-dependent transcription, regulation mechanism, overview, CaM-kinase signaling pathways, it plays a role in anti-apoptotic signaling, overview ?
-
 ?
2.7.11.17 additional information Homo sapiens CaM-Ks are involved in cell cycle regulation and centrosome replication, as well as in development of cancer via calmodulin activity, overview, CaM-KI is involved in CDK4/cyclin D1 activity in fibroblasts, CaM-KIV induces CREB-dependent transcription, regulation mechanism, overview, CaM-kinase signaling pathways, it plays a role in anti-apoptotic signaling, overview ?
-
 ?
2.7.11.17 additional information Rattus norvegicus CaM-Ks are involved in cell cycle regulation and centrosome replication, as well as in development of cancer via calmodulin activity, overview, CaM-KI is involved in CDK4/cyclin D1 activity in fibroblasts, CaM-KIV induces CREB-dependent transcription, regulation mechanism, overview, CaM-kinase signaling pathways, it plays a role in anti-apoptotic signaling, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.17 Homo sapiens
-
 CaM-KII is encoded by four different genes encoding isozymes alpha-delta, alternative splicing results in 24 different enzyme variants
-
2.7.11.17 Mus musculus
-
 CaM-KII is encoded by four different genes encoding isozymes alpha-delta, alternative splicing results in 24 different enzyme variants
-
2.7.11.17 Rattus norvegicus
-
 CaM-KII is encoded by four different genes encoding isozymes alpha-delta, alternative splicing results in 24 different enzyme variants
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.17 phosphoprotein CaM-KIV is phosphorylated and activated by the CaM-K kinase at Thr200, CaM-KI is also phosphorylated by CaM-KK, CaM-kinases II and IV become reversibly autophosphorylated after Ca2+/calmodulin-dependent activation, which renders the enzyme activity autonomous, CaM-KII is phosphorylated in the pseudosubstrate domain Mus musculus
2.7.11.17 phosphoprotein CaM-KIV is phosphorylated and activated by the CaM-K kinase at Thr200, CaM-KI is also phosphorylated by CaM-KK, CaM-kinases II and IV become reversibly autophosphorylated after Ca2+/calmodulin-dependent activation, which renders the enzyme activity autonomous, CaM-KII is phosphorylated in the pseudosubstrate domain Homo sapiens
2.7.11.17 phosphoprotein CaM-KIV is phosphorylated and activated by the CaM-K kinase at Thr200, CaM-KI is also phosphorylated by CaM-KK, CaM-kinases II and IV become reversibly autophosphorylated after Ca2+/calmodulin-dependent activation, which renders the enzyme activity autonomous, CaM-KII is phosphorylated in the pseudosubstrate domain Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.17 brain
-
 Mus musculus
-
2.7.11.17 brain
-
 Homo sapiens
-
2.7.11.17 brain
-
 Rattus norvegicus
-
2.7.11.17 breast cancer cell
-
 Homo sapiens
-
2.7.11.17 fibroblast CaM-KI Mus musculus
-
2.7.11.17 fibroblast CaM-KI Homo sapiens
-
2.7.11.17 fibroblast CaM-KI Rattus norvegicus
-
2.7.11.17 HeLa cell
-
 Homo sapiens
-
2.7.11.17 hepatoma cell
-
 Homo sapiens
-
2.7.11.17 JURKAT cell
-
 Homo sapiens
-
2.7.11.17 liver CaM-KIV Mus musculus
-
2.7.11.17 liver CaM-KIV Homo sapiens
-
2.7.11.17 liver CaM-KIV Rattus norvegicus
-
2.7.11.17 neuron
-
 Mus musculus
-
2.7.11.17 neuron
-
 Homo sapiens
-
2.7.11.17 neuron
-
 Rattus norvegicus
-
2.7.11.17 prostate cancer cell
-
 Homo sapiens
-
2.7.11.17 T-lymphocyte high expression of CaM-KIV Mus musculus
-
2.7.11.17 T-lymphocyte high expression of CaM-KIV Homo sapiens
-
2.7.11.17 T-lymphocyte high expression of CaM-KIV Rattus norvegicus
-
2.7.11.17 testis high expression of CaM-KIV Mus musculus
-
2.7.11.17 testis high expression of CaM-KIV Homo sapiens
-
2.7.11.17 testis high expression of CaM-KIV Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.17 ATP + Akt substrate of CaM-KII, phosphorylation at Thr308 Mus musculus ADP + phosphorylated Akt
-
 ?
2.7.11.17 ATP + Akt substrate of CaM-KII, phosphorylation at Thr308 Homo sapiens ADP + phosphorylated Akt
-
 ?
2.7.11.17 ATP + Akt substrate of CaM-KII, phosphorylation at Thr308 Rattus norvegicus ADP + phosphorylated Akt
-
 ?
2.7.11.17 ATP + CREB i.e. cAMP-response element binding protein, substrate of CaM-KI, phosphorylation at Ser133 Mus musculus ADP + phosphorylated CREB
-
 ?
2.7.11.17 ATP + CREB i.e. cAMP-response element binding protein, substrate of CaM-KI, phosphorylation at Ser133 Homo sapiens ADP + phosphorylated CREB
-
 ?
2.7.11.17 ATP + CREB i.e. cAMP-response element binding protein, substrate of CaM-KI, phosphorylation at Ser133 Rattus norvegicus ADP + phosphorylated CREB
-
 ?
2.7.11.17 ATP + I-kappaB substrate of CaM-KII in T-lymphocytes and neurons, phosphorylation leads to activation of I-kappa B, which mediates activation of NF-kappaB Mus musculus ADP + phosphorylated I-kappaB
-
 ?
2.7.11.17 ATP + I-kappaB substrate of CaM-KII in T-lymphocytes and neurons, phosphorylation leads to activation of I-kappa B, which mediates activation of NF-kappaB Homo sapiens ADP + phosphorylated I-kappaB
-
 ?
2.7.11.17 ATP + I-kappaB substrate of CaM-KII in T-lymphocytes and neurons, phosphorylation leads to activation of I-kappa B, which mediates activation of NF-kappaB Rattus norvegicus ADP + phosphorylated I-kappaB
-
 ?
2.7.11.17 ATP + I-kappaB substrate of CaM-KII Mus musculus ADP + phosphorylated I-kappaB
-
 ?
2.7.11.17 ATP + I-kappaB substrate of CaM-KII Homo sapiens ADP + phosphorylated I-kappaB
-
 ?
2.7.11.17 ATP + I-kappaB substrate of CaM-KII Rattus norvegicus ADP + phosphorylated I-kappaB
-
 ?
2.7.11.17 ATP + synapsin I substrate of CaM-KI Mus musculus ADP + phosphorylated synapsin I
-
 ?
2.7.11.17 ATP + synapsin I substrate of CaM-KI Homo sapiens ADP + phosphorylated synapsin I
-
 ?
2.7.11.17 ATP + synapsin I substrate of CaM-KI Rattus norvegicus ADP + phosphorylated synapsin I
-
 ?
2.7.11.17 ATP + synapsin II substrate of CaM-KI Mus musculus ADP + phosphorylated synapsin II
-
 ?
2.7.11.17 ATP + synapsin II substrate of CaM-KI Homo sapiens ADP + phosphorylated synapsin II
-
 ?
2.7.11.17 ATP + synapsin II substrate of CaM-KI Rattus norvegicus ADP + phosphorylated synapsin II
-
 ?
2.7.11.17 additional information CaM-Ks are involved in cell cycle regulation and centrosome replication, as well as in development of cancer via calmodulin activity, overview, CaM-KI is involved in CDK4/cyclin D1 activity in fibroblasts, CaM-KIV induces CREB-dependent transcription, regulation mechanism, overview, CaM-kinase signaling pathways, it plays a role in anti-apoptotic signaling, overview Mus musculus ?
-
 ?
2.7.11.17 additional information CaM-Ks are involved in cell cycle regulation and centrosome replication, as well as in development of cancer via calmodulin activity, overview, CaM-KI is involved in CDK4/cyclin D1 activity in fibroblasts, CaM-KIV induces CREB-dependent transcription, regulation mechanism, overview, CaM-kinase signaling pathways, it plays a role in anti-apoptotic signaling, overview Homo sapiens ?
-
 ?
2.7.11.17 additional information CaM-Ks are involved in cell cycle regulation and centrosome replication, as well as in development of cancer via calmodulin activity, overview, CaM-KI is involved in CDK4/cyclin D1 activity in fibroblasts, CaM-KIV induces CREB-dependent transcription, regulation mechanism, overview, CaM-kinase signaling pathways, it plays a role in anti-apoptotic signaling, overview Rattus norvegicus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.17 multimer CaM-KII is a multimer of 10-12 catalytic subunits due to self-association Mus musculus
2.7.11.17 multimer CaM-KII is a multimer of 10-12 catalytic subunits due to self-association Homo sapiens
2.7.11.17 multimer CaM-KII is a multimer of 10-12 catalytic subunits due to self-association Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
2.7.11.17 calcium/calmodulin-dependent protein kinase
-
 Mus musculus
2.7.11.17 calcium/calmodulin-dependent protein kinase
-
 Homo sapiens
2.7.11.17 calcium/calmodulin-dependent protein kinase
-
 Rattus norvegicus
2.7.11.17 CaM-K I
-
 Mus musculus
2.7.11.17 CaM-K I
-
 Homo sapiens
2.7.11.17 CaM-K I
-
 Rattus norvegicus
2.7.11.17 CaM-K II
-
 Mus musculus
2.7.11.17 CaM-K II
-
 Homo sapiens
2.7.11.17 CaM-K II
-
 Rattus norvegicus
2.7.11.17 CaM-K IV
-
 Mus musculus
2.7.11.17 CaM-K IV
-
 Homo sapiens
2.7.11.17 CaM-K IV
-
 Rattus norvegicus
2.7.11.17 CaM-kinase I
-
 Mus musculus
2.7.11.17 CaM-kinase I
-
 Homo sapiens
2.7.11.17 CaM-kinase I
-
 Rattus norvegicus
2.7.11.17 CaM-kinase II
-
 Mus musculus
2.7.11.17 CaM-kinase II
-
 Homo sapiens
2.7.11.17 CaM-kinase II
-
 Rattus norvegicus
2.7.11.17 CaM-kinase III
-
 Mus musculus
2.7.11.17 CaM-kinase III
-
 Homo sapiens
2.7.11.17 CaM-kinase III
-
 Rattus norvegicus
2.7.11.17 CaM-kinase IV
-
 Mus musculus
2.7.11.17 CaM-kinase IV
-
 Homo sapiens
2.7.11.17 CaM-kinase IV
-
 Rattus norvegicus
2.7.11.17 More the enzyme belongs to the family of CaM-kinases, overview Mus musculus
2.7.11.17 More the enzyme belongs to the family of CaM-kinases, overview Homo sapiens
2.7.11.17 More the enzyme belongs to the family of CaM-kinases, overview Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.17 ATP
-
 Mus musculus
2.7.11.17 ATP
-
 Homo sapiens
2.7.11.17 ATP
-
 Rattus norvegicus