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Literature summary extracted from

  • Ahn, B.H.; Min, G.; Bae, Y.S.; Min do, S.
    Phospholipase D is activated and phosphorylated by casein kinase-II in human U87 astroglioma cells (2006), Exp. Mol. Med., 38, 55-62.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.1 transient expression of CKII alpha and beta subunits in human U87 astroglioma cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.1.4.4 additional information overexpression of isoforms PLD1 and PLD2, but not their inactive mutants, stimulates Co2+-induced COX-2 expression and prostaglandin E2 production. PLD1 enhances COX-2 expression by Co2+ via reactive oxygen species, p38 MAK kinase, PKC-delta, and PKA, but not ERK, whereas PLD2 enhances Co2+-induced COX-2 expression via reactive oxygen species and p38 MAP kinase, but not PKC-delta, PKA and ERK Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.1 apigenin a CKII-specific inhibitor Homo sapiens
2.7.11.1 emodin a CKII-specific inhibitor Homo sapiens
3.1.4.4 1-butanol inhibitor of enzyme. Pretreatment with 1-butanol suppresses Co2+-induced COX-2 expression and prostaglandin E2 formation Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.1 Mn2+
-
 Homo sapiens
3.1.4.4 Co2+ stimulation of enzyme activity and synthesis of COX-2 protein in time- and dose-dependent manner. Elevated expression of isoforms PLD1 and PLD2 increases hypoxia-induced COX-2 expression and prostaglandin E2 production. PLD1 enhances COX-2 expression by Co2+ via reactive oxygen species, p38 MAK kinase, PKC-delta, and PKA, but not ERK, whereas PLD2 enhances Co2+-induced COX-2 expression via reactive oxygen species and p38 MAP kinase, but not PKC-delta, PKA and ERK Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.1 ATP + phospholipase D Homo sapiens CKII is involved in 4beta-phorbol 12-myristate 13-acetate-induced phospholipase D activation, of PLD1 or PLD2 activity as well as basal PLD activity ADP + phosphorylated phospholipase D
-
 ?
3.1.4.4 additional information Homo sapiens protein casein kinase II stimulates basal phospholipase D (PLD1 and PLD2) activity as well as PMA-induced phospholipase D activation in human U87 astroglioma cells ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.1 Homo sapiens
-
 constitutive enzyme
-
3.1.4.4 Homo sapiens
-
-
-
3.1.4.4 Homo sapiens O14939
-
-
3.1.4.4 Homo sapiens Q13393
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.4 U-87MG cell
-
 Homo sapiens
-
3.1.4.4 U-87MG cell astroglioma cell Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.1 ATP + phospholipase D
-
 Homo sapiens ADP + phosphorylated phospholipase D
-
 ?
2.7.11.1 ATP + phospholipase D CKII is involved in 4beta-phorbol 12-myristate 13-acetate-induced phospholipase D activation, of PLD1 or PLD2 activity as well as basal PLD activity Homo sapiens ADP + phosphorylated phospholipase D
-
 ?
3.1.4.4 additional information protein casein kinase II stimulates basal phospholipase D (PLD1 and PLD2) activity as well as PMA-induced phospholipase D activation in human U87 astroglioma cells Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.1 casein kinase-II
-
 Homo sapiens
2.7.11.1 protein casein kinase II
-
 Homo sapiens
3.1.4.4 PLD1
-
 Homo sapiens
3.1.4.4 PLD2
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.1 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.1 7.4
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.1 ATP
-
 Homo sapiens