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Literature summary extracted from

  • Medina, M.G.; Ledesma, M.D.; Dominguez, J.E.; Medina, M.; Zafra, D.; Alameda, F.; Dotti, C.G.; Navarro, P.
    Tissue plasminogen activator mediates amyloid-induced neurotoxicity via Erk1/2 activation (2005), EMBO J., 24, 1706-1716.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.68 2,7-bis-(4-amidinobenzylidene)-cycloheptanone-(1)dihydrochloride
-
Mus musculus
3.4.21.68 2,7-bis-(4-amidinobenzylidene)-cycloheptanone-(1)dihydrochloride
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.68 plasminogen + H2O Mus musculus
-
plasmin + ?
-
?
3.4.21.68 plasminogen + H2O Rattus norvegicus
-
plasmin + ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.68 Mus musculus P11214
-
-
3.4.21.68 Rattus norvegicus P19637
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.68 brain primary hippocampal neuron Mus musculus
-
3.4.21.68 brain primary hippocampal neuron Rattus norvegicus
-
3.4.21.68 Neuro-2a cell
-
Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.68 plasminogen + H2O
-
Mus musculus plasmin + ?
-
?
3.4.21.68 plasminogen + H2O
-
Rattus norvegicus plasmin + ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.68 Tissue plasminogen activator
-
Mus musculus
3.4.21.68 Tissue plasminogen activator
-
Rattus norvegicus
3.4.21.68 tPA
-
Mus musculus
3.4.21.68 tPA
-
Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.21.68 0.000035
-
2,7-bis-(4-amidinobenzylidene)-cycloheptanone-(1)dihydrochloride
-
Mus musculus
3.4.21.68 0.000035
-
2,7-bis-(4-amidinobenzylidene)-cycloheptanone-(1)dihydrochloride
-
Rattus norvegicus