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Literature summary extracted from
- Identification of two apurinic/apyrimidinic endonucleases from Caenorhabditis elegans by cross-species complementation (2005), DNA Repair, 4, 655-670.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 4.2.99.18 | apn-1 gene of Caenorhabditis elegans expresses AP endonuclease activity in yeast mutants | Caenorhabditis elegans |
| 4.2.99.18 | exo-3 gene of Caenorhabditis elegans expresses AP endonuclease activity in yeast mutants | Caenorhabditis elegans |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 4.2.99.18 | D190A | mutant enzyme is completely devoid of DNA repair activity and fails to rescue the genetic instability of Saccharomyces cerevisiae strain YW778 | Caenorhabditis elegans |
| 4.2.99.18 | E68A | mutant retains both AP endonuclease and 3'-diesterase repair activity, lacks ability to protect Saccharomyces cerevisiae strain YW778 from spontaneous and drug-induced DNA lesions | Caenorhabditis elegans |
| 4.2.99.18 | H279A | mutant enzyme is completely devoid of DNA repair activity and fails to rescue the genetic instability of Saccharomyces cerevisiae strain YW778 | Caenorhabditis elegans |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.2.99.18 | Caenorhabditis elegans | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 4.2.99.18 | GST-EXO-3 fusion protein and GST-E68A fusion protein | Caenorhabditis elegans |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.2.99.18 | APN-1 | - |
Caenorhabditis elegans |
| 4.2.99.18 | EXO-3 | - |
Caenorhabditis elegans |
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