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Literature summary extracted from

  • Pelaia, G.; Cuda, G.; Vatrella, A.; Fratto, D.; Tagliaferri, P.; Maselli, R.; Costanzo, F.S.; Marsico, S.A.
    Mitogen-activated protein kinases: new molecular targets for pharmacological treatment of inflammatory lung diseases (2003), Curr. Med. Chem., 2, 131-141.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.24 interleukin-1beta activates the MAPKs, dexamethasone inhibits this activation Homo sapiens
2.7.11.24 additional information oxidative stress activates the MAPKs, dexamethasone inhibits this activation Homo sapiens
2.7.11.24 TNF-alpha activates the MAPKs, dexamethasone inhibits this activation Homo sapiens
2.7.11.24 transforming growth factor-beta i.e. TGF-beta, activates p38, butenoside inhibits this activation Homo sapiens

Application

EC Number Application Comment Organism
2.7.11.24 medicine MAPKs are a molecular targets for pharmacological treatment of inflammatory lung diseases Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.24 additional information Homo sapiens MAPKs, e.g. p38, play a key role in the transductin of biological signals from cell surface receptors, through the cytoplasm, to the transcriptional machinery in the nucleus ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.24 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.24 bronchus primary epithelial cells Homo sapiens
-
2.7.11.24 endothelial cell
-
Homo sapiens
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2.7.11.24 epithelial cell primary Homo sapiens
-
2.7.11.24 vascular endothelial cell of airway and alveolar endothelium Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.24 additional information MAPKs, e.g. p38, play a key role in the transductin of biological signals from cell surface receptors, through the cytoplasm, to the transcriptional machinery in the nucleus Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.24 p38
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Homo sapiens