EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.24 | interleukin-1beta | activates the MAPKs, dexamethasone inhibits this activation | Homo sapiens | |
2.7.11.24 | additional information | oxidative stress activates the MAPKs, dexamethasone inhibits this activation | Homo sapiens | |
2.7.11.24 | TNF-alpha | activates the MAPKs, dexamethasone inhibits this activation | Homo sapiens | |
2.7.11.24 | transforming growth factor-beta | i.e. TGF-beta, activates p38, butenoside inhibits this activation | Homo sapiens |
EC Number | Application | Comment | Organism |
---|---|---|---|
2.7.11.24 | medicine | MAPKs are a molecular targets for pharmacological treatment of inflammatory lung diseases | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.24 | additional information | Homo sapiens | MAPKs, e.g. p38, play a key role in the transductin of biological signals from cell surface receptors, through the cytoplasm, to the transcriptional machinery in the nucleus | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.11.24 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.11.24 | bronchus | primary epithelial cells | Homo sapiens | - |
2.7.11.24 | endothelial cell | - |
Homo sapiens | - |
2.7.11.24 | epithelial cell | primary | Homo sapiens | - |
2.7.11.24 | vascular endothelial cell | of airway and alveolar endothelium | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.24 | additional information | MAPKs, e.g. p38, play a key role in the transductin of biological signals from cell surface receptors, through the cytoplasm, to the transcriptional machinery in the nucleus | Homo sapiens | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.11.24 | p38 | - |
Homo sapiens |