EC Number | Application | Comment | Organism |
---|---|---|---|
3.1.3.5 | medicine | in patients with acute lymphoblastic leukemia, enzyme activity decreases during 6-mercaptopurine treatment to about 50% of initial activity. After 6 weeks of treatment, there is a significant negative correlation between thio-GMP levels and enzyme activity | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.1.3.5 | additional information | no product inhibition by 6-thioguanosine | Homo sapiens | |
3.1.3.5 | thio-IMP | substrate inhibition | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.3.5 | Homo sapiens | - |
patients with acute lymphoblastic leukemia during 6-mercaptopurine treatment | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.3.5 | 5'-AMP + H2O | - |
Homo sapiens | adenosine + phosphate | - |
? | |
3.1.3.5 | 5'-GMP + H2O | - |
Homo sapiens | guanosine + phosphate | - |
? | |
3.1.3.5 | 5'-IMP + H2O | - |
Homo sapiens | inosine + phosphate | - |
? | |
3.1.3.5 | methylthio-IMP + H2O | - |
Homo sapiens | ? + phosphate | - |
? | |
3.1.3.5 | thio-GMP + H2o | - |
Homo sapiens | 6-thioguanosine + phosphate | - |
? | |
3.1.3.5 | thio-IMP + H2O | - |
Homo sapiens | 6-thioinosine + phosphate | - |
? |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.1.3.5 | 7 | - |
substrate thio-IMP | Homo sapiens |
3.1.3.5 | 7.5 | - |
substrates IMP, methylthio-IMP | Homo sapiens |
3.1.3.5 | 8 | - |
substrate thio-GMP | Homo sapiens |
3.1.3.5 | 8.5 | - |
substrates GMP, AMP | Homo sapiens |