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Literature summary extracted from

  • Brouwer, C.; Vogels-Mentink, T.M.; Keizer-Garritsen, J.J.; Trijbels, F.J.; Bokkerink, J.P.; Hoogerbrugge, P.M.; van Wering, E.R.; Veerman, A.J.; De Abreu, R.A.
    Role of 5'-nucleotidase in thiopurine metabolism: enzyme kinetic profile and association with thio-GMP levels in patients with acute lymphoblastic leukemia during 6-mercaptopurine treatment (2005), Clin. Chim. Acta, 361, 95-103.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.3.5 medicine in patients with acute lymphoblastic leukemia, enzyme activity decreases during 6-mercaptopurine treatment to about 50% of initial activity. After 6 weeks of treatment, there is a significant negative correlation between thio-GMP levels and enzyme activity Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.5 additional information no product inhibition by 6-thioguanosine Homo sapiens
3.1.3.5 thio-IMP substrate inhibition Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.5 Homo sapiens
-
patients with acute lymphoblastic leukemia during 6-mercaptopurine treatment
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.5 5'-AMP + H2O
-
Homo sapiens adenosine + phosphate
-
?
3.1.3.5 5'-GMP + H2O
-
Homo sapiens guanosine + phosphate
-
?
3.1.3.5 5'-IMP + H2O
-
Homo sapiens inosine + phosphate
-
?
3.1.3.5 methylthio-IMP + H2O
-
Homo sapiens ? + phosphate
-
?
3.1.3.5 thio-GMP + H2o
-
Homo sapiens 6-thioguanosine + phosphate
-
?
3.1.3.5 thio-IMP + H2O
-
Homo sapiens 6-thioinosine + phosphate
-
?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.3.5 7
-
substrate thio-IMP Homo sapiens
3.1.3.5 7.5
-
substrates IMP, methylthio-IMP Homo sapiens
3.1.3.5 8
-
substrate thio-GMP Homo sapiens
3.1.3.5 8.5
-
substrates GMP, AMP Homo sapiens