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Literature summary extracted from

  • Franscini, N.; Bachli, E.B.; Blau, N.; Fischler, M.; Walter, R.B.; Schaffner, A.; Schoedon, G.
    Functional tetrahydrobiopterin synthesis in human platelets (2004), Circulation, 110, 186-192.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.3.12 7,8-dihydroneopterin triphosphate Homo sapiens
-
 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.3.12 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.3.12 blood platelet
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.2.3.12 additional information
-
 5.3 pmol/min/10*10 platelets, PTPS activity does not change significantly after treatment with glucocorticoids in a dose equivalent to at least 100 mg prednisone for at least 7 days, enzyme assays at 37°C Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.3.12 7,8-dihydroneopterin triphosphate
-
 Homo sapiens 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.3.12 6-pyruvoyltetrahydropterin synthase
-
 Homo sapiens
4.2.3.12 PTPS
-
 Homo sapiens