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Literature summary extracted from

  • Zhang, T.; Brown, J.H.
    Role of Ca2+/calmodulin-dependent protein kinase II in cardiac hypertrophy and heart failure (2004), Cardiovasc. Res., 63, 476-486.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.17 Calmodulin dependent on, Ca2+/calmodulin activate CaMKII prior to autophosphorylation which renders the enzyme independent of Ca2+/calmodulin Mus musculus
2.7.11.17 Calmodulin dependent on, Ca2+/calmodulin activate CaMKII prior to autophosphorylation which renders the enzyme independent of Ca2+/calmodulin Homo sapiens
2.7.11.17 Calmodulin dependent on, Ca2+/calmodulin activate CaMKII prior to autophosphorylation which renders the enzyme independent of Ca2+/calmodulin Rattus norvegicus
2.7.11.17 Calmodulin dependent on, Ca2+/calmodulin activate CaMKII prior to autophosphorylation which renders the enzyme independent of Ca2+/calmodulin Sus scrofa
2.7.11.17 Calmodulin dependent on, Ca2+/calmodulin activate CaMKII prior to autophosphorylation which renders the enzyme independent of Ca2+/calmodulin Oryctolagus cuniculus
2.7.11.17 additional information the enzyme is regulated by de-/phosphorylation Mus musculus
2.7.11.17 additional information the enzyme is regulated by de-/phosphorylation Homo sapiens
2.7.11.17 additional information the enzyme is regulated by de-/phosphorylation Rattus norvegicus
2.7.11.17 additional information the enzyme is regulated by de-/phosphorylation Sus scrofa
2.7.11.17 additional information the enzyme is regulated by de-/phosphorylation Oryctolagus cuniculus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.17 additional information construction of transgenic mice overexpressing calmodulin, the mutant mice develop severe cardiac hypertrophy and show increased Ca2+/calmodulin-independent CaMKII activity, overexpression of CaMKIV and CaMKIV knockout also lead to development of cardiac hypertrophy, CaMKIIdeltaB overexpressing transgenic mice do not phosphorylate CREB Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.17 KN-93
-
 Homo sapiens
2.7.11.17 KN-93
-
 Mus musculus
2.7.11.17 KN-93
-
 Oryctolagus cuniculus
2.7.11.17 KN-93
-
 Rattus norvegicus
2.7.11.17 KN-93
-
 Sus scrofa
2.7.11.17 additional information CaMKII possesses an autoinhibitory domain, the enzyme is regulated by de-/phosphorylation Homo sapiens
2.7.11.17 additional information CaMKII possesses an autinhibitory domain, the enzyme is regulated by de-/phosphorylation Mus musculus
2.7.11.17 additional information CaMKII possesses an autoinhibitory domain, the enzyme is regulated by de-/phosphorylation Oryctolagus cuniculus
2.7.11.17 additional information CaMKII possesses an autoinhibitory domain, the enzyme is regulated by de-/phosphorylation Rattus norvegicus
2.7.11.17 additional information CaMKII possesses an autoinhibitory domain, the enzyme is regulated by de-/phosphorylation Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.17 cytoplasm isozyme CaMKIIdelta splicing variant deltaC, CaMKIV Mus musculus 5737
-
2.7.11.17 cytoplasm isozyme CaMKIIdelta splicing variant deltaC, CaMKIV Homo sapiens 5737
-
2.7.11.17 cytoplasm isozyme CaMKIIdelta splicing variant deltaC, CaMKIV Rattus norvegicus 5737
-
2.7.11.17 cytoplasm isozyme CaMKIIdelta splicing variant deltaC, CaMKIV Sus scrofa 5737
-
2.7.11.17 cytoplasm isozyme CaMKIIdelta splicing variant deltaC, CaMKIV Oryctolagus cuniculus 5737
-
2.7.11.17 nucleus isozyme CaMKIIdelta splicing variant deltaB, CaMKIV predominantly Mus musculus 5634
-
2.7.11.17 nucleus isozyme CaMKIIdelta splicing variant deltaB, CaMKIV predominantly Homo sapiens 5634
-
2.7.11.17 nucleus isozyme CaMKIIdelta splicing variant deltaB, CaMKIV predominantly Rattus norvegicus 5634
-
2.7.11.17 nucleus isozyme CaMKIIdelta splicing variant deltaB, CaMKIV predominantly Sus scrofa 5634
-
2.7.11.17 nucleus isozyme CaMKIIdelta splicing variant deltaB, CaMKIV predominantly Oryctolagus cuniculus 5634
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.17 Ca2+ dependent on, Ca2+/calmodulin activate CaMKII prior to autophosphorylation which renders the enzyme independent of Ca2+/calmodulin Mus musculus
2.7.11.17 Ca2+ dependent on, Ca2+/calmodulin activate CaMKII prior to autophosphorylation which renders the enzyme independent of Ca2+/calmodulin Homo sapiens
2.7.11.17 Ca2+ dependent on, Ca2+/calmodulin activate CaMKII prior to autophosphorylation which renders the enzyme independent of Ca2+/calmodulin Rattus norvegicus
2.7.11.17 Ca2+ dependent on, Ca2+/calmodulin activate CaMKII prior to autophosphorylation which renders the enzyme independent of Ca2+/calmodulin Sus scrofa
2.7.11.17 Ca2+ dependent on, Ca2+/calmodulin activate CaMKII prior to autophosphorylation which renders the enzyme independent of Ca2+/calmodulin Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.17 ATP + cAMP-response element binding protein Rattus norvegicus i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133 ADP + phosphorylated cAMP-response element binding protein
-
 ?
2.7.11.17 ATP + cAMP-response element binding protein Mus musculus i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133, and phosphorylation by CaMKII at Ser142 ADP + phosphorylated cAMP-response element binding protein
-
 ?
2.7.11.17 ATP + cAMP-response element binding protein Homo sapiens i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133, and phosphorylation by CaMKII at Ser142 ADP + phosphorylated cAMP-response element binding protein
-
 ?
2.7.11.17 ATP + cAMP-response element binding protein Sus scrofa i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133, and phosphorylation by CaMKII at Ser142 ADP + phosphorylated cAMP-response element binding protein
-
 ?
2.7.11.17 ATP + cAMP-response element binding protein Oryctolagus cuniculus i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133, and phosphorylation by CaMKII at Ser142 ADP + phosphorylated cAMP-response element binding protein
-
 ?
2.7.11.17 ATP + MEF-2A Mus musculus phosphorylation by CaMKIV ADP + phosphorylated MEF-2A
-
 ?
2.7.11.17 ATP + MEF-2C Mus musculus phosphorylation by CaMKIV ADP + phosphorylated MEF-2C
-
 ?
2.7.11.17 ATP + MEF-2D Mus musculus phosphorylation by CaMKIV ADP + phosphorylated MEF-2D
-
 ?
2.7.11.17 additional information Mus musculus CaMKII is a critical Ca2+ signaling transducer, CaMKII isozyme have special roles in regulating cardiac function determined by their subcellular localization, nuclear CaMKIIdeltaB plays a key role in hypertrophic gene expression, cytosolic CaMKIIdeltaC can affect excitation-contraction-coupling through phosphorylation of Ca2+-regulatory proteins and may introduce signals leading to apoptosis, CaMKII is involved in cardiac hypertrophy and heart failure, signaling pathways, overview, CaMK is involved in regulation of various transcription factors and other DNA-binding proteins, overview ?
-
 ?
2.7.11.17 additional information Rattus norvegicus CaMKII is a critical Ca2+ signaling transducer, CaMKII isozyme have special roles in regulating cardiac function determined by their subcellular localization, nuclear CaMKIIdeltaB plays a key role in hypertrophic gene expression, cytosolic CaMKIIdeltaC can affect excitation-contraction-coupling through phosphorylation of Ca2+-regulatory proteins and may introduce signals leading to apoptosis, CaMKII is involved in cardiac hypertrophy and heart failure, signaling pathways, overview, CaMK is involved in regulation of various transcription factors and other DNA-binding proteins, overview ?
-
 ?
2.7.11.17 additional information Sus scrofa CaMKII is a critical Ca2+ signaling transducer, CaMKII isozyme have special roles in regulating cardiac function determined by their subcellular localization, nuclear CaMKIIdeltaB plays a key role in hypertrophic gene expression, cytosolic CaMKIIdeltaC can affect excitation-contraction-coupling through phosphorylation of Ca2+-regulatory proteins and may introduce signals leading to apoptosis, CaMKII is involved in cardiac hypertrophy and heart failure, signaling pathways, overview, CaMK is involved in regulation of various transcription factors and other DNA-binding proteins, overview ?
-
 ?
2.7.11.17 additional information Oryctolagus cuniculus CaMKII is a critical Ca2+ signaling transducer, CaMKII isozyme have special roles in regulating cardiac function determined by their subcellular localization, nuclear CaMKIIdeltaB plays a key role in hypertrophic gene expression, cytosolic CaMKIIdeltaC can affect excitation-contraction-coupling through phosphorylation of Ca2+-regulatory proteins and may introduce signals leading to apoptosis, CaMKII is involved in cardiac hypertrophy and heart failure, signaling pathways, overview, CaMK is involved in regulation of various transcription factors and other DNA-binding proteins, overview ?
-
 ?
2.7.11.17 additional information Homo sapiens CaMKII is a critical Ca2+ signaling transducer, CaMKII isozyme have special roles in regulating cardiac function determined by their subcellular localization, nuclear CaMKIIdeltaB plays a key role in hypertrophic gene expression, cytosolic CaMKIIdeltaC can affect excitation-contraction-coupling through phosphorylation of Ca2+-regulatory proteins and may introduce signals leading to apoptosis, CaMKII is involved in cardiac hypertrophy, CaMKIIdeltaB expression is increased in heart failure, about 2fold in failing cardiomyopathy, signaling pathways, overview, CaMK is involved in regulation of various transcription factors and other DNA-binding proteins, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.17 Homo sapiens
-
 isozyme CaMKIIdelta exists in two splicing variants deltaB and deltaC in the heart
-
2.7.11.17 Mus musculus
-
 isozyme CaMKIIdelta exists in two splicing variants deltaB and deltaC in the heart
-
2.7.11.17 Oryctolagus cuniculus
-
 isozyme CaMKIIdelta exists in two splicing variants deltaB and deltaC in the heart
-
2.7.11.17 Rattus norvegicus
-
 isozyme CaMKIIdelta exists in two splicing variants deltaB and deltaC in the heart
-
2.7.11.17 Sus scrofa
-
 isozyme CaMKIIdelta exists in two splicing variants deltaB and deltaC in the heart
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.17 phosphoprotein Ca2+/calmodulin-bound CaMKIIdelta is further activated by autophosphorylation at Thr287beta/gamma and Thr286alpha in the autoinhibitory domain, as well as at Thr306/Thr307beta/gamma and Thr305/Thr306alpha rendering the enzyme independent of Ca2+/calmodulin Homo sapiens
2.7.11.17 phosphoprotein Ca2+/calmodulin-bound CaMKIIdelta is further activated by autophosphorylation at Thr287beta/gamma and Thr286alpha in the autoinhibitory domain, as well as at Thr306/Thr307beta/gamma and Thr305/Thr306alpha rendering the enzyme independent of Ca2+/calmodulin Rattus norvegicus
2.7.11.17 phosphoprotein Ca2+/calmodulin-bound CaMKIIdelta is further activated by autophosphorylation at Thr287beta/gamma and Thr286alpha in the autoinhibitory domain, as well as at Thr306/Thr307beta/gamma and Thr305/Thr306alpha rendering the enzyme independent of Ca2+/calmodulin Sus scrofa
2.7.11.17 phosphoprotein Ca2+/calmodulin-bound CaMKIIdelta is further activated by autophosphorylation at Thr287beta/gamma and Thr286alpha in the autoinhibitory domain, as well as at Thr306/Thr307beta/gamma and Thr305/Thr306alpha rendering the enzyme independent of Ca2+/calmodulin Oryctolagus cuniculus
2.7.11.17 phosphoprotein Ca2+/calmodulin-bound CaMKIIdelta is further activated by autophosphorylation at Thr287beta/gamma and Thr286alpha in the autoinhibitory domain, as wellas at Thr306/Thr307beta/gamma and Thr305/Thr306alpha rendering the enzyme independent of Ca2+/calmodulin Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.17 cardiac muscle
-
 Mus musculus
-
2.7.11.17 cardiac muscle
-
 Homo sapiens
-
2.7.11.17 cardiac muscle
-
 Rattus norvegicus
-
2.7.11.17 cardiac muscle
-
 Sus scrofa
-
2.7.11.17 cardiac muscle
-
 Oryctolagus cuniculus
-
2.7.11.17 heart CaMKII, no expression of CaMKIV Mus musculus
-
2.7.11.17 heart CaMKII, no expression of CaMKIV Homo sapiens
-
2.7.11.17 heart CaMKII, no expression of CaMKIV Rattus norvegicus
-
2.7.11.17 heart CaMKII, no expression of CaMKIV Sus scrofa
-
2.7.11.17 heart CaMKII, no expression of CaMKIV Oryctolagus cuniculus
-
2.7.11.17 additional information ubiquitous expression of CaMKII Mus musculus
-
2.7.11.17 additional information ubiquitous expression of CaMKII Homo sapiens
-
2.7.11.17 additional information ubiquitous expression of CaMKII Rattus norvegicus
-
2.7.11.17 additional information ubiquitous expression of CaMKII Sus scrofa
-
2.7.11.17 additional information ubiquitous expression of CaMKII Oryctolagus cuniculus
-
2.7.11.17 myocardium isozyme CaMKIIdelta splicing variants deltaB and deltaC Mus musculus
-
2.7.11.17 myocardium isozyme CaMKIIdelta splicing variants deltaB and deltaC Homo sapiens
-
2.7.11.17 myocardium isozyme CaMKIIdelta splicing variants deltaB and deltaC Rattus norvegicus
-
2.7.11.17 myocardium isozyme CaMKIIdelta splicing variants deltaB and deltaC Sus scrofa
-
2.7.11.17 myocardium isozyme CaMKIIdelta splicing variants deltaB and deltaC Oryctolagus cuniculus
-
2.7.11.17 neuron CaMKIV Mus musculus
-
2.7.11.17 neuron CaMKIV Homo sapiens
-
2.7.11.17 neuron CaMKIV Rattus norvegicus
-
2.7.11.17 neuron CaMKIV Sus scrofa
-
2.7.11.17 neuron CaMKIV Oryctolagus cuniculus
-
2.7.11.17 T-lymphocyte CaMKIV Mus musculus
-
2.7.11.17 T-lymphocyte CaMKIV Homo sapiens
-
2.7.11.17 T-lymphocyte CaMKIV Rattus norvegicus
-
2.7.11.17 T-lymphocyte CaMKIV Sus scrofa
-
2.7.11.17 T-lymphocyte CaMKIV Oryctolagus cuniculus
-
2.7.11.17 testis CaMKIV Mus musculus
-
2.7.11.17 testis CaMKIV Homo sapiens
-
2.7.11.17 testis CaMKIV Rattus norvegicus
-
2.7.11.17 testis CaMKIV Sus scrofa
-
2.7.11.17 testis CaMKIV Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.17 ATP + cAMP-response element binding protein i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133 Rattus norvegicus ADP + phosphorylated cAMP-response element binding protein
-
 ?
2.7.11.17 ATP + cAMP-response element binding protein i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133, and phosphorylation by CaMKII at Ser142 Mus musculus ADP + phosphorylated cAMP-response element binding protein
-
 ?
2.7.11.17 ATP + cAMP-response element binding protein i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133, and phosphorylation by CaMKII at Ser142 Homo sapiens ADP + phosphorylated cAMP-response element binding protein
-
 ?
2.7.11.17 ATP + cAMP-response element binding protein i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133, and phosphorylation by CaMKII at Ser142 Rattus norvegicus ADP + phosphorylated cAMP-response element binding protein
-
 ?
2.7.11.17 ATP + cAMP-response element binding protein i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133, and phosphorylation by CaMKII at Ser142 Sus scrofa ADP + phosphorylated cAMP-response element binding protein
-
 ?
2.7.11.17 ATP + cAMP-response element binding protein i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133, and phosphorylation by CaMKII at Ser142 Oryctolagus cuniculus ADP + phosphorylated cAMP-response element binding protein
-
 ?
2.7.11.17 ATP + MEF-2A phosphorylation by CaMKIV Mus musculus ADP + phosphorylated MEF-2A
-
 ?
2.7.11.17 ATP + MEF-2C phosphorylation by CaMKIV Mus musculus ADP + phosphorylated MEF-2C
-
 ?
2.7.11.17 ATP + MEF-2D phosphorylation by CaMKIV Mus musculus ADP + phosphorylated MEF-2D
-
 ?
2.7.11.17 additional information CaMKII is a critical Ca2+ signaling transducer, CaMKII isozyme have special roles in regulating cardiac function determined by their subcellular localization, nuclear CaMKIIdeltaB plays a key role in hypertrophic gene expression, cytosolic CaMKIIdeltaC can affect excitation-contraction-coupling through phosphorylation of Ca2+-regulatory proteins and may introduce signals leading to apoptosis, CaMKII is involved in cardiac hypertrophy and heart failure, signaling pathways, overview, CaMK is involved in regulation of various transcription factors and other DNA-binding proteins, overview Mus musculus ?
-
 ?
2.7.11.17 additional information CaMKII is a critical Ca2+ signaling transducer, CaMKII isozyme have special roles in regulating cardiac function determined by their subcellular localization, nuclear CaMKIIdeltaB plays a key role in hypertrophic gene expression, cytosolic CaMKIIdeltaC can affect excitation-contraction-coupling through phosphorylation of Ca2+-regulatory proteins and may introduce signals leading to apoptosis, CaMKII is involved in cardiac hypertrophy and heart failure, signaling pathways, overview, CaMK is involved in regulation of various transcription factors and other DNA-binding proteins, overview Rattus norvegicus ?
-
 ?
2.7.11.17 additional information CaMKII is a critical Ca2+ signaling transducer, CaMKII isozyme have special roles in regulating cardiac function determined by their subcellular localization, nuclear CaMKIIdeltaB plays a key role in hypertrophic gene expression, cytosolic CaMKIIdeltaC can affect excitation-contraction-coupling through phosphorylation of Ca2+-regulatory proteins and may introduce signals leading to apoptosis, CaMKII is involved in cardiac hypertrophy and heart failure, signaling pathways, overview, CaMK is involved in regulation of various transcription factors and other DNA-binding proteins, overview Sus scrofa ?
-
 ?
2.7.11.17 additional information CaMKII is a critical Ca2+ signaling transducer, CaMKII isozyme have special roles in regulating cardiac function determined by their subcellular localization, nuclear CaMKIIdeltaB plays a key role in hypertrophic gene expression, cytosolic CaMKIIdeltaC can affect excitation-contraction-coupling through phosphorylation of Ca2+-regulatory proteins and may introduce signals leading to apoptosis, CaMKII is involved in cardiac hypertrophy and heart failure, signaling pathways, overview, CaMK is involved in regulation of various transcription factors and other DNA-binding proteins, overview Oryctolagus cuniculus ?
-
 ?
2.7.11.17 additional information CaMKII is a critical Ca2+ signaling transducer, CaMKII isozyme have special roles in regulating cardiac function determined by their subcellular localization, nuclear CaMKIIdeltaB plays a key role in hypertrophic gene expression, cytosolic CaMKIIdeltaC can affect excitation-contraction-coupling through phosphorylation of Ca2+-regulatory proteins and may introduce signals leading to apoptosis, CaMKII is involved in cardiac hypertrophy, CaMKIIdeltaB expression is increased in heart failure, about 2fold in failing cardiomyopathy, signaling pathways, overview, CaMK is involved in regulation of various transcription factors and other DNA-binding proteins, overview Homo sapiens ?
-
 ?
2.7.11.17 additional information CaMKII is a multifunctional enzyme Mus musculus ?
-
 ?
2.7.11.17 additional information CaMKII is a multifunctional enzyme Homo sapiens ?
-
 ?
2.7.11.17 additional information CaMKII is a multifunctional enzyme Rattus norvegicus ?
-
 ?
2.7.11.17 additional information CaMKII is a multifunctional enzyme Sus scrofa ?
-
 ?
2.7.11.17 additional information CaMKII is a multifunctional enzyme Oryctolagus cuniculus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.17 multimer CaMKII, hetero- or homomultimer Homo sapiens
2.7.11.17 multimer CaMKII, hetero- or homomultimer Rattus norvegicus
2.7.11.17 multimer CaMKII, hetero- or homomultimer Sus scrofa
2.7.11.17 multimer CaMKII, hetero- or homomultimer Oryctolagus cuniculus
2.7.11.17 multimer CaMKII, hetero-or homonultimer Mus musculus

Synonyms

EC Number Synonyms Comment Organism
2.7.11.17 Ca2+/calmodulin-dependent protein kinase II
-
 Mus musculus
2.7.11.17 Ca2+/calmodulin-dependent protein kinase II
-
 Homo sapiens
2.7.11.17 Ca2+/calmodulin-dependent protein kinase II
-
 Rattus norvegicus
2.7.11.17 Ca2+/calmodulin-dependent protein kinase II
-
 Sus scrofa
2.7.11.17 Ca2+/calmodulin-dependent protein kinase II
-
 Oryctolagus cuniculus
2.7.11.17 CaMKII
-
 Mus musculus
2.7.11.17 CaMKII
-
 Homo sapiens
2.7.11.17 CaMKII
-
 Rattus norvegicus
2.7.11.17 CaMKII
-
 Sus scrofa
2.7.11.17 CaMKII
-
 Oryctolagus cuniculus
2.7.11.17 CaMKIV
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.17 ATP
-
 Mus musculus
2.7.11.17 ATP
-
 Homo sapiens
2.7.11.17 ATP
-
 Rattus norvegicus
2.7.11.17 ATP
-
 Sus scrofa
2.7.11.17 ATP
-
 Oryctolagus cuniculus