Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Andres, V.
    Control of vascular cell proliferation and migration by cyclin-dependent kinase signalling: new perspectives and therapeutic potential (2004), Cardiovasc. Res., 63, 11-21.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.22 additional information CDKs are activated by phosphorylation Mus musculus
2.7.11.22 additional information CDKs are activated by phosphorylation Homo sapiens
2.7.11.22 additional information CDKs are activated by phosphorylation Rattus norvegicus

Application

EC Number Application Comment Organism
2.7.11.22 medicine the CDK-cyclins are targets for pharmacological and gene therapy strategies for the treatment of cardiovascular disease Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.22 additional information construction of CDK-null mutant mice Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.22 CDK inhibitory proteins members of the family of CDK inhibitory proteins, e.g. INK4 proteins, overview, CKIs may play a role as regulators in neointimal hyperplasia Homo sapiens
2.7.11.22 CDK inhibitory proteins members of the family of CDK inhibitory proteins, e.g. INK4 proteins, overview, CKIs may play a role as regulators in neointimal hyperplasia Mus musculus
2.7.11.22 CDK inhibitory proteins members of the family of CDK inhibitory proteins, e.g. INK4 proteins, overview, CKIs may play a role as regulators in neointimal hyperplasia Rattus norvegicus
2.7.11.22 CVT-313 inhibitor used in treatment of neointimal hyperplasia, IC50 for CDK1 is 0.004 mM, for CDK2 0.0005 mM, and for CDK4 0.215 mM Rattus norvegicus
2.7.11.22 flavopiridol inhibitor used in treatment of neointimal hyperplasia, IC50 for CDK1 is 0.0005 mM, for CDK2 0.0001 mM, for CDK4 0.000065 mM, for CDK6 0.00006 mM, and for CDK7 0.00011-0.0003 mM Rattus norvegicus
2.7.11.22 INK4 proteins inhibit CDK4 Homo sapiens
2.7.11.22 INK4 proteins inhibit CDK4 Mus musculus
2.7.11.22 INK4 proteins inhibit CDK4 Rattus norvegicus
2.7.11.22 additional information physiological effects of CDK inhibition, overview, CDKs are deactivated by dephosphorylation, protein p27Kip1 mediates CDK2 inhibition Homo sapiens
2.7.11.22 additional information physiological effects of CDK inhibition, overview, CDKs are deactivated by dephosphorylation, protein p27Kip1 mediates CDK2 inhibition Mus musculus
2.7.11.22 additional information physiological effects of CDK inhibition, overview, CDKs are deactivated by dephosphorylation, protein p27Kip1 mediates CDK2 inhibition Rattus norvegicus
2.7.11.22 p15Ink4b INK4 protein Homo sapiens
2.7.11.22 p15Ink4b INK4 protein Mus musculus
2.7.11.22 p15Ink4b INK4 protein Rattus norvegicus
2.7.11.22 p16Ink4a INK4 protein Homo sapiens
2.7.11.22 p16Ink4a INK4 protein Mus musculus
2.7.11.22 p16Ink4a INK4 protein Rattus norvegicus
2.7.11.22 p18Ink4c INK4 protein Homo sapiens
2.7.11.22 p18Ink4c INK4 protein Mus musculus
2.7.11.22 p18Ink4c INK4 protein Rattus norvegicus
2.7.11.22 p19Ink4d INK4 protein Homo sapiens
2.7.11.22 p19Ink4d INK4 protein Mus musculus
2.7.11.22 p19Ink4d INK4 protein Rattus norvegicus
2.7.11.22 simvastatin inhibition of CDK2 Homo sapiens
2.7.11.22 simvastatin inhibition of CDK2 Mus musculus
2.7.11.22 simvastatin inhibition of CDK2 Rattus norvegicus
2.7.11.22 tranilast inhibition of CDK2 and CDK4 Homo sapiens
2.7.11.22 tranilast inhibition of CDK2 and CDK4 Mus musculus
2.7.11.22 tranilast inhibition of CDK2 and CDK4 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.22 ATP + pocket protein p107 Mus musculus hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis ADP + phosphorylated pocket protein 107
-
 ?
2.7.11.22 ATP + pocket protein p107 Homo sapiens hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis ADP + phosphorylated pocket protein 107
-
 ?
2.7.11.22 ATP + pocket protein p107 Rattus norvegicus hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis ADP + phosphorylated pocket protein 107
-
 ?
2.7.11.22 ATP + pocket protein p130 Mus musculus hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis ADP + phosphorylated pocket protein 130
-
 ?
2.7.11.22 ATP + pocket protein p130 Homo sapiens hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis ADP + phosphorylated pocket protein 130
-
 ?
2.7.11.22 ATP + pocket protein p130 Rattus norvegicus hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis ADP + phosphorylated pocket protein 130
-
 ?
2.7.11.22 ATP + retinoblastoma protein Mus musculus i.e. Rb protein, hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis ADP + phosphorylated retinoblastoma protein
-
 ?
2.7.11.22 ATP + retinoblastoma protein Homo sapiens i.e. Rb protein, hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis ADP + phosphorylated retinoblastoma protein
-
 ?
2.7.11.22 ATP + retinoblastoma protein Rattus norvegicus i.e. Rb protein, hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis ADP + phosphorylated retinoblastoma protein
-
 ?
2.7.11.22 additional information Mus musculus CDK-cyclins and CDK inhibitory proteins are involved in the cell cycle regulation and of vascular cell proliferation and migration, as well as in the control of neointimal thickening, modeling, overview ?
-
 ?
2.7.11.22 additional information Homo sapiens CDK-cyclins and CDK inhibitory proteins are involved in the cell cycle regulation and of vascular cell proliferation and migration, as well as in the control of neointimal thickening, modeling, overview ?
-
 ?
2.7.11.22 additional information Rattus norvegicus CDK-cyclins and CDK inhibitory proteins are involved in the cell cycle regulation and of vascular cell proliferation and migration, as well as in the control of neointimal thickening, modeling, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.22 Homo sapiens
-
-
-
2.7.11.22 Mus musculus
-
-
-
2.7.11.22 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.22 phosphoprotein CDK is regulated by de-/phosphorylation Mus musculus
2.7.11.22 phosphoprotein CDK is regulated by de-/phosphorylation Homo sapiens
2.7.11.22 phosphoprotein CDK is regulated by de-/phosphorylation Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.22 keratinocyte
-
 Mus musculus
-
2.7.11.22 keratinocyte
-
 Homo sapiens
-
2.7.11.22 keratinocyte
-
 Rattus norvegicus
-
2.7.11.22 additional information different CDK-cyclins are orderly activated at specific phases of the cell cycle Homo sapiens
-
2.7.11.22 vascular cell
-
 Mus musculus
-
2.7.11.22 vascular cell
-
 Homo sapiens
-
2.7.11.22 vascular cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.22 ATP + pocket protein p107 hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis Mus musculus ADP + phosphorylated pocket protein 107
-
 ?
2.7.11.22 ATP + pocket protein p107 hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis Homo sapiens ADP + phosphorylated pocket protein 107
-
 ?
2.7.11.22 ATP + pocket protein p107 hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis Rattus norvegicus ADP + phosphorylated pocket protein 107
-
 ?
2.7.11.22 ATP + pocket protein p107 hyperphosphorylation by CDK/cyclin Mus musculus ADP + phosphorylated pocket protein 107
-
 ?
2.7.11.22 ATP + pocket protein p107 hyperphosphorylation by CDK/cyclin Homo sapiens ADP + phosphorylated pocket protein 107
-
 ?
2.7.11.22 ATP + pocket protein p107 hyperphosphorylation by CDK/cyclin Rattus norvegicus ADP + phosphorylated pocket protein 107
-
 ?
2.7.11.22 ATP + pocket protein p130 hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis Mus musculus ADP + phosphorylated pocket protein 130
-
 ?
2.7.11.22 ATP + pocket protein p130 hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis Homo sapiens ADP + phosphorylated pocket protein 130
-
 ?
2.7.11.22 ATP + pocket protein p130 hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis Rattus norvegicus ADP + phosphorylated pocket protein 130
-
 ?
2.7.11.22 ATP + pocket protein p130 hyperphosphorylation by CDK/cyclin Mus musculus ADP + phosphorylated pocket protein 130
-
 ?
2.7.11.22 ATP + pocket protein p130 hyperphosphorylation by CDK/cyclin Homo sapiens ADP + phosphorylated pocket protein 130
-
 ?
2.7.11.22 ATP + pocket protein p130 hyperphosphorylation by CDK/cyclin Rattus norvegicus ADP + phosphorylated pocket protein 130
-
 ?
2.7.11.22 ATP + retinoblastoma protein i.e. Rb protein, hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis Mus musculus ADP + phosphorylated retinoblastoma protein
-
 ?
2.7.11.22 ATP + retinoblastoma protein i.e. Rb protein, hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis Homo sapiens ADP + phosphorylated retinoblastoma protein
-
 ?
2.7.11.22 ATP + retinoblastoma protein i.e. Rb protein, hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis Rattus norvegicus ADP + phosphorylated retinoblastoma protein
-
 ?
2.7.11.22 ATP + retinoblastoma protein i.e. Rb protein, hyperphosphorylation by CDK/cyclin Mus musculus ADP + phosphorylated retinoblastoma protein
-
 ?
2.7.11.22 ATP + retinoblastoma protein i.e. Rb protein, hyperphosphorylation by CDK/cyclin Homo sapiens ADP + phosphorylated retinoblastoma protein
-
 ?
2.7.11.22 ATP + retinoblastoma protein i.e. Rb protein, hyperphosphorylation by CDK/cyclin Rattus norvegicus ADP + phosphorylated retinoblastoma protein
-
 ?
2.7.11.22 additional information CDK-cyclins and CDK inhibitory proteins are involved in the cell cycle regulation and of vascular cell proliferation and migration, as well as in the control of neointimal thickening, modeling, overview Mus musculus ?
-
 ?
2.7.11.22 additional information CDK-cyclins and CDK inhibitory proteins are involved in the cell cycle regulation and of vascular cell proliferation and migration, as well as in the control of neointimal thickening, modeling, overview Homo sapiens ?
-
 ?
2.7.11.22 additional information CDK-cyclins and CDK inhibitory proteins are involved in the cell cycle regulation and of vascular cell proliferation and migration, as well as in the control of neointimal thickening, modeling, overview Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.22 CDK
-
 Mus musculus
2.7.11.22 CDK
-
 Homo sapiens
2.7.11.22 CDK
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.22 ATP
-
 Mus musculus
2.7.11.22 ATP
-
 Homo sapiens
2.7.11.22 ATP
-
 Rattus norvegicus
2.7.11.22 cyclin regulatory subunit of CDK Mus musculus
2.7.11.22 cyclin regulatory subunit of CDK Homo sapiens
2.7.11.22 cyclin regulatory subunit of CDK Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.11.22 0.00006
-
 IC50 for CDK6 0.00006 mM Rattus norvegicus flavopiridol
2.7.11.22 0.000065
-
 IC50 for CDK4 0.000065 mM Rattus norvegicus flavopiridol
2.7.11.22 0.0001
-
 IC50 for CDK2 0.0001 mM Rattus norvegicus flavopiridol
2.7.11.22 0.00011 0.0003 IC50 for CDK7 0.00011-0.0003 mM Rattus norvegicus flavopiridol
2.7.11.22 0.0005
-
 inhibitor used in treatment of neointimal hyperplasia, IC50 for CDK1 is 0.0005 mM Rattus norvegicus flavopiridol
2.7.11.22 0.0005
-
 IC50 for CDK2 0.0005 mM Rattus norvegicus CVT-313
2.7.11.22 0.004
-
 inhibitor used in treatment of neointimal hyperplasia, IC50 for CDK1 is 0.004 mM Rattus norvegicus CVT-313
2.7.11.22 0.215
-
 IC50 for CDK4 0.215 mM Rattus norvegicus CVT-313