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Literature summary extracted from

  • Rodriguez-Mora, O.G.; LaHair, M.M.; McCubrey, J.A.; Franklin, R.A.
    Calcium/calmodulin-dependent kinase I and calcium/calmodulin-dependent kinase kinase participate in the control of cell cycle progression in MCF-7 human breast cancer cells (2005), Cancer Res., 65, 5408-5416.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.17 Calmodulin dependent on, intracellular calcium receptor Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.17 additional information CaM-KI inhibition by expression of siRNA causes cell cycle arrest in MCF-7 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.17 KN-93 CaM-KI and CaMKII, CaMKI inhibition in vivo causes cell cycle arrest in MCF-7 cells and reduction in cyclin D1 and Rb protein phosphorylation Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.17 Ca2+ dependent on Homo sapiens
2.7.11.17 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.17 additional information Homo sapiens CaM-KI and calcium/calmodulin-dependent kinase kinase CaM-KK participate in the control of cell cycle progression in MCF-7 human breast cancer cells, CaM-KK controls the G0-G1 restriction check point ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.17 Homo sapiens Q14012
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.17 phosphoprotein CaMKI and CaMKII are phosphorylated by the calcium/calmodulin-dependent kinase kinase CaM-KK isozymes, regulatory role, overview Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.17 breast cancer cell differential expression of CaM-KI and CaM-KII in cell lines MCF-7 and MCF-10A Homo sapiens
-
2.7.11.17 MCF-10A cell breast cancer cell line Homo sapiens
-
2.7.11.17 MCF-7 cell breast cancer cell line Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.17 additional information CaM-KI and calcium/calmodulin-dependent kinase kinase CaM-KK participate in the control of cell cycle progression in MCF-7 human breast cancer cells, CaM-KK controls the G0-G1 restriction check point Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.17 calcium/calmodulin-dependent kinase I
-
 Homo sapiens
2.7.11.17 CaM-KI
-
 Homo sapiens
2.7.11.17 CaM-KII
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.17 ATP
-
 Homo sapiens