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Literature summary extracted from

  • Toscano, C.D.; O'Callaghan, J.P.; Guilarte, T.R.
    Calcium/calmodulin-dependent protein kinase II activity and expression are altered in the hippocampus of Pb2+-exposed rats (2005), Brain Res., 1044, 51-58.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.17 Calmodulin
-
 Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.17 EGTA
-
 Rattus norvegicus
2.7.11.17 KN-93
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.11.17 additional information
-
 additional information developmental Pb2+ exposure of rats alters the reaction kinetics of CaMKII in the hippocampus compared to rats grown in absence of Pb2+ Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.17 cytosol isozymes CaMKII alpha and CaMKIIbeta, contents of isozymes in membrane and cytosol of Pb2+ treated and untreated rats, overview Rattus norvegicus 5829
-
2.7.11.17 membrane isozymes CaMKII alpha and CaMKIIbeta, contents of isozymes in membrane and cytosol of Pb2+ treated and untreated rats, overview Rattus norvegicus 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.17 Ca2+
-
 Rattus norvegicus
2.7.11.17 Mg2+
-
 Rattus norvegicus
2.7.11.17 Pb2+ CaMKII activity and expression are altered in the hippocampus of Pb2+-exposed rats, reaction velocity is reduced by 41% and substrate affinity is increased by 22%, the rats exhibit deficits in hippocampal log-term potentiation and spatial learning, the content of CaMKIIbeta, but not of CaMKIIalpha, in the cytosolic fraction is reduced Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.17 additional information Rattus norvegicus CaMKII is involved in calcium signaling, synaptic plasticity, learning, and memory, CaMKII activity and expression are altered in the hippocampus of Pb2+-exposed rats, reaction velocity is reduced by 41% and substrate affinity is increased by 22%, the rats exhibit deficits in hippocampal log-term potentiation and spatial learning ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.17 Rattus norvegicus
-
 female LOng-Evans rats, isozymes CaMKIIalpha and beta
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.17 phosphoprotein CaMKII is autophosphorylated at Thr286 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.17 brain brains-specific isozymes CaMKII alpha and CaMKIIbeta Rattus norvegicus
-
2.7.11.17 hippocampus isozymes CaMKII alpha and CaMKIIbeta Rattus norvegicus
-
2.7.11.17 additional information rats grown with developmental exposure to Pb2+ Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.17 additional information CaMKII is involved in calcium signaling, synaptic plasticity, learning, and memory, CaMKII activity and expression are altered in the hippocampus of Pb2+-exposed rats, reaction velocity is reduced by 41% and substrate affinity is increased by 22%, the rats exhibit deficits in hippocampal log-term potentiation and spatial learning Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.17 Ca2+/calmodulin-dependent protein kinase II
-
 Rattus norvegicus
2.7.11.17 CaMKII
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.17 30
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.17 7.5
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.17 ATP
-
 Rattus norvegicus