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Literature summary extracted from

  • Kim, J.H.; Curtis-Long, M.J.; Seo, W.D.; Lee, J.H.; Lee, B.W.; Yoon, Y.J.; Kang, K.Y.; Park, K.H.
    alpha-Rhamnosidase inhibitory activities of polyhydroxylated pyrrolidine (2005), Bioorg. Med. Chem. Lett., 15, 4282-4285.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.40 (2S,3R,4S)-benzyl-3,4-dihydroxy pyrrolidine IC50 is 0.168 mM Penicillium decumbens
3.2.1.40 (2S,3R,4S)-deacetyl anisomycin IC50 is 0.137 mM Penicillium decumbens
3.2.1.40 (2S,3S,4R)-benzyl-3,4-dihydroxy pyrrolidine competitive Penicillium decumbens
3.2.1.40 (2S,3S,4R)-deacetyl anisomycin competitive Penicillium decumbens
3.2.1.40 (2S,3S,4S)-anisomycin competitive Penicillium decumbens
3.2.1.40 (2S,3S,4S)-deacetyl anisomycin competitive Penicillium decumbens
3.2.1.40 additional information design from aromatic amino acids and inhibitory potency of polyhydroxylated pyrrolidines, stereochemistry, overview Penicillium decumbens

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.40 Penicillium decumbens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.40 4-nitrophenyl alpha-L-rhamnopyranoside + H2O
-
 Penicillium decumbens 4-nitrophenol + alpha-L-rhamnose
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.2.1.40 30
-
 assay at Penicillium decumbens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.2.1.40 6.7
-
 assay at Penicillium decumbens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.2.1.40 0.0026
-
 (2S,3S,4R)-deacetyl anisomycin pH 6.7, 30°C, versus 4-nitrophenyl alpha-L-rhamnopyranoside Penicillium decumbens
3.2.1.40 0.0029
-
 (2S,3R,4S)-benzyl-3,4-dihydroxy pyrrolidine pH 6.7, 30°C, versus 4-nitrophenyl alpha-L-rhamnopyranoside Penicillium decumbens
3.2.1.40 0.0029
-
 (2S,3S,4S)-deacetyl anisomycin pH 6.7, 30°C, versus 4-nitrophenyl alpha-L-rhamnopyranoside Penicillium decumbens
3.2.1.40 0.058
-
 (2S,3S,4S)-anisomycin pH 6.7, 30°C, versus 4-nitrophenyl alpha-L-rhamnopyranoside Penicillium decumbens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.2.1.40 0.137
-
 IC50 is 0.137 mM Penicillium decumbens (2S,3R,4S)-deacetyl anisomycin
3.2.1.40 0.168
-
 IC50 is 0.168 mM Penicillium decumbens (2S,3R,4S)-benzyl-3,4-dihydroxy pyrrolidine