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Literature summary extracted from

  • Kim, S.E.; Kim, S.Y.; KI, S.; Kang, T.; Lee, J.
    Deoxyribosyl analogues of methionyl and isoleucyl sulfamate adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetase (2005), Bioorg. Med. Chem. Lett., 15, 3389-3393.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.1.1.5 2,3-dideoxy-adenosine-5-[(2S,3S)-2-amino-3-methylpentanoyl]-sulfamate IC50: 0.0064 mM Escherichia coli
6.1.1.5 2-deoxy-adenosine-5-[(2S,3S)-2-amino-3-methylpentanoyl]-sulfamate IC50: 0.28 mM Escherichia coli
6.1.1.5 3-deoxy-adenosine-5-[(2S,3S)-2-amino-3-methylpentanoyl]-sulfamate IC50: 0.035 mM Escherichia coli
6.1.1.5 adenosine-5-[(2S,3S)-2-amino-3-methylpentanoyl]-sulfamate IC50: 0.000265 mM Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.5 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.5 ATP + L-isoleucine + tRNAIle
-
 Escherichia coli AMP + diphosphate + L-isoleucyl-tRNAIle
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.1.1.5 IleRS
-
 Escherichia coli

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
6.1.1.5 0.000265
-
 IC50: 0.000265 mM Escherichia coli adenosine-5-[(2S,3S)-2-amino-3-methylpentanoyl]-sulfamate
6.1.1.5 0.0064
-
 IC50: 0.0064 mM Escherichia coli 2,3-dideoxy-adenosine-5-[(2S,3S)-2-amino-3-methylpentanoyl]-sulfamate
6.1.1.5 0.035
-
 IC50: 0.035 mM Escherichia coli 3-deoxy-adenosine-5-[(2S,3S)-2-amino-3-methylpentanoyl]-sulfamate
6.1.1.5 0.28
-
 IC50: 0.28 mM Escherichia coli 2-deoxy-adenosine-5-[(2S,3S)-2-amino-3-methylpentanoyl]-sulfamate