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Literature summary extracted from
- Slow-binding inhibition of 2-keto-3-deoxy-6-phosphogluconate (KDPG) aldolase (2004), Bioorg. Med. Chem., 12, 2965-2972.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.2.14 | 2,4-dioxo-4-phenylbutanoic acid | - |
Escherichia coli |  |
| 4.1.2.14 | 2,4-dioxo-4-[2-(trifluoromethyl)phenyl]butanoic acid | - |
Escherichia coli | |
| 4.1.2.14 | 2,4-dioxo-4-[3-(trifluoromethyl)phenyl]butanoic acid | - |
Escherichia coli | |
| 4.1.2.14 | 2,4-dioxo-4-[4-(trifluoromethyl)phenyl]butanoic acid | - |
Escherichia coli | |
| 4.1.2.14 | 4-(3-methoxyphenyl)-2,4-dioxobutanoic acid | - |
Escherichia coli | |
| 4.1.2.14 | 4-(4-methoxyphenyl)-2,4-dioxobutanoic acid | - |
Escherichia coli | |
| 4.1.2.14 | acetylpyruvic acid | - |
Escherichia coli | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.1.2.14 | 0.06 | - |
2-dehydro-3-deoxy-D-gluconate 6-phosphate | pH 7.6, 25°C | Escherichia coli | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.2.14 | Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.2.14 | 2-dehydro-3-deoxy-D-gluconate 6-phosphate | - |
Escherichia coli | pyruvate + D-glyceraldehyde 3-phosphate | - |
? | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.1.2.14 | 0.03 | - |
2,4-dioxo-4-[3-(trifluoromethyl)phenyl]butanoic acid | pH 7.6, 25°C | Escherichia coli | |
| 4.1.2.14 | 0.04 | - |
2,4-dioxo-4-[2-(trifluoromethyl)phenyl]butanoic acid | pH 7.6, 25°C | Escherichia coli | |
| 4.1.2.14 | 0.07 | - |
2,4-dioxo-4-phenylbutanoic acid | pH 7.6, 25°C | Escherichia coli | |
| 4.1.2.14 | 0.075 | - |
4-(3-methoxyphenyl)-2,4-dioxobutanoic acid | pH 7.6, 25°C | Escherichia coli | |
| 4.1.2.14 | 0.18 | - |
4-(4-methoxyphenyl)-2,4-dioxobutanoic acid | pH 7.6, 25°C | Escherichia coli | |
| 4.1.2.14 | 0.25 | - |
acetylpyruvic acid | pH 7.6, 25°C | Escherichia coli | |
| 4.1.2.14 | 0.38 | - |
2,4-dioxo-4-[4-(trifluoromethyl)phenyl]butanoic acid | pH 7.6, 25°C | Escherichia coli | |
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