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Literature summary extracted from

  • Chahinian, H.; Ali, Y.B.; Abousalham, A.; Petry, S.; Mandrich, L.; Manco, G.; Canaan, S.; Sarda, L.
    Substrate specificity and kinetic properties of enzymes belonging to the hormone-sensitive lipase family: comparison with non-lipolytic and lipolytic carboxylesterases (2005), Biochim. Biophys. Acta, 1738, 29-36.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.1.1 0.04
-
 4-nitrophenyl butanoate pH 7.5, 25°C Archaeoglobus fulgidus
3.1.1.1 0.05
-
 4-nitrophenyl butanoate pH 7.5, 25°C Alicyclobacillus acidocaldarius
3.1.1.1 0.05
-
 tributyrin pH 7.5, 25°C Archaeoglobus fulgidus
3.1.1.1 0.07
-
 tributyrin pH 7.5, 25°C Alicyclobacillus acidocaldarius
3.1.1.1 0.3
-
 tripropionin pH 7.5, 25°C Archaeoglobus fulgidus
3.1.1.1 0.4
-
 tributyrin pH 7.5, 25°C Homo sapiens
3.1.1.1 0.75
-
 tripropionin pH 7.5, 25°C Alicyclobacillus acidocaldarius
3.1.1.1 1
-
 4-nitrophenyl butanoate pH 7.5, 25°C Homo sapiens
3.1.1.1 2.5
-
 vinyl acetate pH 7.5, 25°C Alicyclobacillus acidocaldarius
3.1.1.1 2.5
-
 vinyl butanoate pH 7.5, 25°C Archaeoglobus fulgidus
3.1.1.1 3
-
 vinyl laurate pH 7.5, 25°C Homo sapiens
3.1.1.1 3
-
 vinyl butanoate pH 7.5, 25°C Alicyclobacillus acidocaldarius
3.1.1.1 4
-
 vinyl acetate pH 7.5, 25°C Archaeoglobus fulgidus
3.1.1.1 6
-
 vinyl propionate pH 7.5, 25°C Alicyclobacillus acidocaldarius
3.1.1.1 7
-
 vinyl propionate pH 7.5, 25°C Archaeoglobus fulgidus
3.1.1.1 10
-
 Triacetin pH 7.5, 25°C Archaeoglobus fulgidus
3.1.1.1 11
-
 vinyl butanoate pH 7.5, 25°C Homo sapiens
3.1.1.1 12
-
 Triacetin pH 7.5, 25°C Alicyclobacillus acidocaldarius
3.1.1.1 15
-
 tripropionin pH 7.5, 25°C Homo sapiens
3.1.1.1 70
-
 vinyl propionate pH 7.5, 25°C Homo sapiens
3.1.1.1 170
-
 vinyl acetate pH 7.5, 25°C Homo sapiens
3.1.1.79 0.4
-
 tributyrin
-
 Homo sapiens
3.1.1.79 4
-
 vinyl laurate
-
 Homo sapiens
3.1.1.79 15
-
 tripropionin
-
 Homo sapiens
3.1.1.79 25
-
 vinyl butyrate
-
 Homo sapiens
3.1.1.79 75
-
 vinyl propionate
-
 Homo sapiens
3.1.1.79 315
-
 vinyl acetate
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.1 Alicyclobacillus acidocaldarius
-
-
-
3.1.1.1 Archaeoglobus fulgidus
-
-
-
3.1.1.1 Homo sapiens
-
 isoform hormone-sensitive lipase
-
3.1.1.79 Homo sapiens
-
 recombinant
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.1 4-nitrophenyl butanoate + H2O
-
 Homo sapiens 4-nitrophenol + butanoate
-
 ?
3.1.1.1 4-nitrophenyl butanoate + H2O
-
 Archaeoglobus fulgidus 4-nitrophenol + butanoate
-
 ?
3.1.1.1 4-nitrophenyl butanoate + H2O
-
 Alicyclobacillus acidocaldarius 4-nitrophenol + butanoate
-
 ?
3.1.1.1 triacetin + H2O
-
 Archaeoglobus fulgidus ?
-
 ?
3.1.1.1 triacetin + H2O
-
 Alicyclobacillus acidocaldarius ?
-
 ?
3.1.1.1 tributyrin + H2O
-
 Homo sapiens ?
-
 ?
3.1.1.1 tributyrin + H2O
-
 Archaeoglobus fulgidus ?
-
 ?
3.1.1.1 tributyrin + H2O
-
 Alicyclobacillus acidocaldarius ?
-
 ?
3.1.1.1 tripropionin + H2O
-
 Homo sapiens ?
-
 ?
3.1.1.1 tripropionin + H2O
-
 Archaeoglobus fulgidus ?
-
 ?
3.1.1.1 tripropionin + H2O
-
 Alicyclobacillus acidocaldarius ?
-
 ?
3.1.1.1 vinyl acetate + H2O
-
 Homo sapiens vinyl alcohol + acetate
-
 ?
3.1.1.1 vinyl acetate + H2O
-
 Archaeoglobus fulgidus vinyl alcohol + acetate
-
 ?
3.1.1.1 vinyl acetate + H2O
-
 Alicyclobacillus acidocaldarius vinyl alcohol + acetate
-
 ?
3.1.1.1 vinyl butanoate + H2O
-
 Homo sapiens vinyl alcohol + butanoate
-
 ?
3.1.1.1 vinyl butanoate + H2O
-
 Archaeoglobus fulgidus vinyl alcohol + butanoate
-
 ?
3.1.1.1 vinyl butanoate + H2O
-
 Alicyclobacillus acidocaldarius vinyl alcohol + butanoate
-
 ?
3.1.1.1 vinyl laurate + H2O
-
 Homo sapiens vinyl alcohol + laurate
-
 ?
3.1.1.1 vinyl laurate + H2O
-
 Archaeoglobus fulgidus vinyl alcohol + laurate
-
 ?
3.1.1.1 vinyl laurate + H2O
-
 Alicyclobacillus acidocaldarius vinyl alcohol + laurate
-
 ?
3.1.1.1 vinyl propionate + H2O
-
 Homo sapiens vinyl alcohol + propionate
-
 ?
3.1.1.1 vinyl propionate + H2O
-
 Archaeoglobus fulgidus vinyl alcohol + propionate
-
 ?
3.1.1.1 vinyl propionate + H2O
-
 Alicyclobacillus acidocaldarius vinyl alcohol + propionate
-
 ?
3.1.1.79 p-nitrophenyl butyrate + H2O
-
 Homo sapiens p-nitrophenol + butanoate
-
 ?
3.1.1.79 tributyrin + H2O
-
 Homo sapiens dibutanoylglycerol + butanoate
-
 ?
3.1.1.79 trioctanoin + H2O
-
 Homo sapiens dioctanoylglycerol + octanoate
-
 ?
3.1.1.79 tripropionin + H2O
-
 Homo sapiens dipropanoylglycerol + propanoate
-
 ?
3.1.1.79 vinyl acetate + H2O
-
 Homo sapiens acetate + ethylenol
-
 ?
3.1.1.79 vinyl butyrate + H2O
-
 Homo sapiens butanoate + ethylenol
-
 ?
3.1.1.79 vinyl laurate + H2O
-
 Homo sapiens laurate + ethylenol
-
 ?
3.1.1.79 vinyl propionate + H2O
-
 Homo sapiens propanoate + ethylenol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.1 hormone-sensitive lipase
-
 Homo sapiens
3.1.1.1 HSL
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.1.1.1 7
-
 tripropionin pH 7.5, 25°C Homo sapiens
3.1.1.1 18
-
 tributyrin pH 7.5, 25°C Homo sapiens
3.1.1.1 31
-
 vinyl laurate pH 7.5, 25°C Homo sapiens
3.1.1.1 40
-
 Triacetin pH 7.5, 25°C Archaeoglobus fulgidus
3.1.1.1 50
-
 vinyl acetate pH 7.5, 25°C Archaeoglobus fulgidus
3.1.1.1 95
-
 tributyrin pH 7.5, 25°C Archaeoglobus fulgidus
3.1.1.1 105
-
 vinyl propionate pH 7.5, 25°C Homo sapiens
3.1.1.1 110
-
 vinyl acetate pH 7.5, 25°C Alicyclobacillus acidocaldarius
3.1.1.1 110
-
 tripropionin pH 7.5, 25°C Archaeoglobus fulgidus
3.1.1.1 140
-
 4-nitrophenyl butanoate pH 7.5, 25°C Archaeoglobus fulgidus
3.1.1.1 140
-
 vinyl acetate pH 7.5, 25°C Homo sapiens
3.1.1.1 190
-
 4-nitrophenyl butanoate pH 7.5, 25°C Homo sapiens
3.1.1.1 200
-
 vinyl propionate pH 7.5, 25°C Archaeoglobus fulgidus
3.1.1.1 210
-
 vinyl butanoate pH 7.5, 25°C Homo sapiens
3.1.1.1 210
-
 vinyl butanoate pH 7.5, 25°C Archaeoglobus fulgidus
3.1.1.1 480
-
 4-nitrophenyl butanoate pH 7.5, 25°C Alicyclobacillus acidocaldarius
3.1.1.1 835
-
 tripropionin pH 7.5, 25°C Alicyclobacillus acidocaldarius
3.1.1.1 945
-
 Triacetin pH 7.5, 25°C Alicyclobacillus acidocaldarius
3.1.1.1 980
-
 vinyl propionate pH 7.5, 25°C Alicyclobacillus acidocaldarius
3.1.1.1 1290
-
 tributyrin pH 7.5, 25°C Alicyclobacillus acidocaldarius
3.1.1.1 1930
-
 vinyl butanoate pH 7.5, 25°C Alicyclobacillus acidocaldarius
3.1.1.79 6
-
 trioctanoin
-
 Homo sapiens
3.1.1.79 7
-
 tripropionin
-
 Homo sapiens
3.1.1.79 18
-
 tributyrin
-
 Homo sapiens
3.1.1.79 170
-
 vinyl acetate
-
 Homo sapiens
3.1.1.79 190
-
 p-nitrophenyl butyrate
-
 Homo sapiens
3.1.1.79 375
-
 vinyl laurate
-
 Homo sapiens
3.1.1.79 625
-
 vinyl butyrate
-
 Homo sapiens
3.1.1.79 800
-
 vinyl propionate
-
 Homo sapiens