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Literature summary extracted from

  • Barber, M.C.; Price, N.T.; Travers, M.T.
    Structure and regulation of acetyl-CoA carboxylase genes of metazoa (2005), Biochim. Biophys. Acta, 1733, 1-28.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.4.1.2 citrate allosteric activation, kinetics Gallus gallus
6.4.1.2 citrate allosteric activation, kinetics Ovis aries
6.4.1.2 citrate allosteric activation, kinetics Homo sapiens
6.4.1.2 citrate allosteric activation, kinetics Rattus norvegicus
6.4.1.2 citrate allosteric activation, kinetics Mus musculus
6.4.1.2 D-glutamate allosteric activation Gallus gallus
6.4.1.2 D-glutamate allosteric activation Ovis aries
6.4.1.2 D-glutamate allosteric activation Homo sapiens
6.4.1.2 D-glutamate allosteric activation Rattus norvegicus
6.4.1.2 D-glutamate allosteric activation Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.4.1.2 DNA and amino acid sequence determination and analysis Gallus gallus
6.4.1.2 DNA and amino acid sequence determination and analysis Escherichia coli
6.4.1.2 DNA and amino acid sequence determination and analysis Saccharomyces cerevisiae
6.4.1.2 DNA and amino acid sequence determination and analysis Caenorhabditis elegans
6.4.1.2 DNA and amino acid sequence determination and analysis Ciona intestinalis
6.4.1.2 DNA and amino acid sequence determination and analysis Danio rerio
6.4.1.2 DNA and amino acid sequence determination and analysis Caenorhabditis briggsae
6.4.1.2 DNA and amino acid sequence determination and analysis Takifugu rubripes
6.4.1.2 DNA and amino acid sequence determination and analysis, alternative splicing, overview Ovis aries
6.4.1.2 DNA and amino acid sequence determination and analysis, alternative splicing, overview Rattus norvegicus
6.4.1.2 DNA and amino acid sequence determination and analysis, alternative splicing, the gene encoding isozyme ACC-beta is located on chromosome 12q24, overview Homo sapiens
6.4.1.2 DNA and amino acid sequence determination and analysis, chromosome 12 of all genotypes contains an ACACA pseudogene named acaca-psi, alternative splicing, overview Mus musculus
6.4.1.2 DNA and amino acid sequence determination and analysis, one gene encodes both isozymes, alternative splicing, long and short enzyme forms with different subcellular localization Drosophila melanogaster

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.4.1.2 long-chain fatty acids
-
 Gallus gallus
6.4.1.2 long-chain fatty acids
-
 Homo sapiens
6.4.1.2 long-chain fatty acids
-
 Mus musculus
6.4.1.2 long-chain fatty acids
-
 Ovis aries
6.4.1.2 long-chain fatty acids
-
 Rattus norvegicus
6.4.1.2 malonyl-CoA product inhibition, competitive to acetyl-CoA Gallus gallus
6.4.1.2 malonyl-CoA product inhibition, competitive to acetyl-CoA; product inhibition, competitive to acetyl-CoA Homo sapiens
6.4.1.2 malonyl-CoA product inhibition, competitive to acetyl-CoA; product inhibition, competitive to acetyl-CoA Mus musculus
6.4.1.2 malonyl-CoA product inhibition, competitive to acetyl-CoA Ovis aries
6.4.1.2 malonyl-CoA product inhibition, competitive to acetyl-CoA; product inhibition, competitive to acetyl-CoA Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.4.1.2 cytosol
-
 Caenorhabditis elegans 5829
-
6.4.1.2 cytosol isozyme ACC1 Caenorhabditis briggsae 5829
-
6.4.1.2 cytosol isozyme Acc1p Saccharomyces cerevisiae 5829
-
6.4.1.2 cytosol short enzyme form Drosophila melanogaster 5829
-
6.4.1.2 mitochondrion long enzyme form Drosophila melanogaster 5739
-
6.4.1.2 mitochondrion mitochondrion-specific isozyme ACC2 Caenorhabditis briggsae 5739
-
6.4.1.2 mitochondrion mitochondrion-specific isozyme Hfa1p Saccharomyces cerevisiae 5739
-
6.4.1.2 additional information subcellular location of isozymes, overview Gallus gallus
-
-
6.4.1.2 additional information subcellular location of isozymes, overview Ovis aries
-
-
6.4.1.2 additional information subcellular location of isozymes, overview Rattus norvegicus
-
-
6.4.1.2 additional information subcellular location of isozymes, overview Mus musculus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.4.1.2 265000
-
 1 * 265000, isozyme Acc1 Homo sapiens
6.4.1.2 280000
-
 1 * 280000, isozyme Acc2 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.4.1.2 ATP + acetyl-CoA + HCO3- Escherichia coli
-
 ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- Saccharomyces cerevisiae
-
 ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- Ciona intestinalis
-
 ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- Danio rerio
-
 ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- Takifugu rubripes
-
 ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- Ovis aries first committed step in fatty acid biosynthesis, hormonal, nutrient, and tissue-specific regulation of ACC genes, regulation of isozyme activity, overview ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- Homo sapiens first committed step in fatty acid biosynthesis, hormonal, nutrient, and tissue-specific regulation of ACC genes, regulation of isozyme activity, overview ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- Rattus norvegicus first committed step in fatty acid biosynthesis, hormonal, nutrient, and tissue-specific regulation of ACC genes, regulation of isozyme activity, overview ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- Mus musculus first committed step in fatty acid biosynthesis, hormonal, nutrient, and tissue-specific regulation of ACC genes, regulation of isozyme activity, overview ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- Gallus gallus hormonal, nutrient, and tissue-specific regulation of ACC genes, overview ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- Caenorhabditis elegans regulation of isozyme expression and activity ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- Drosophila melanogaster regulation of isozyme expression and activity, overview ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- Caenorhabditis briggsae regulation of isozyme expression and activity, overview ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- Caenorhabditis elegans W09B6 regulation of isozyme expression and activity ADP + malonyl-CoA + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.4.1.2 Caenorhabditis briggsae
-
-
-
6.4.1.2 Caenorhabditis elegans
-
-
-
6.4.1.2 Caenorhabditis elegans W09B6
-
-
-
6.4.1.2 Ciona intestinalis
-
 single gene
-
6.4.1.2 Danio rerio
-
 zebrafish
-
6.4.1.2 Drosophila melanogaster
-
-
-
6.4.1.2 Escherichia coli
-
-
-
6.4.1.2 Gallus gallus
-
-
-
6.4.1.2 Homo sapiens O00763 isozyme ACC2; gene ACACA, encoding isozyme ACC1 or ACC-alpha, and gene ACACB, encoding isozyme ACC2 or ACC-beta
-
6.4.1.2 Homo sapiens Q13085 isozyme ACC1; gene ACACA, encoding isozyme ACC1 or ACC-alpha, and gene ACACB, encoding isozyme ACC2 or ACC-beta
-
6.4.1.2 Mus musculus Q5SWU9 isozyme ACC1; gene ACACA, encoding isozyme ACC1 or ACC-alpha
-
6.4.1.2 Mus musculus Q6JIZ0 isozyme ACC2; gene ACACB, encoding isozyme ACC2 or ACC-beta
-
6.4.1.2 Ovis aries
-
-
-
6.4.1.2 Rattus norvegicus O70151 isozyme ACC2; gene ACACB, encoding isozyme ACC2 or ACC-beta
-
6.4.1.2 Rattus norvegicus P11497 isozyme ACC1; gene ACACA, encoding isozyme ACC1 or ACC-alpha
-
6.4.1.2 Saccharomyces cerevisiae
-
-
-
6.4.1.2 Takifugu rubripes
-
 puffer fish
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
6.4.1.2 phosphoprotein reversible phosphorylation has regulatory function, differential phosphorylation of isozymes, overview Ovis aries
6.4.1.2 phosphoprotein reversible phosphorylation has regulatory function, differential phosphorylation of isozymes, overview Homo sapiens
6.4.1.2 phosphoprotein reversible phosphorylation has regulatory function, differential phosphorylation of isozymes, overview Mus musculus
6.4.1.2 phosphoprotein the enzyme in liver is regulated by reversible phosphorylation, differential phosphorylation of isozymes, overview Rattus norvegicus

Reaction

EC Number Reaction Comment Organism Reaction ID
6.4.1.2 ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA catalytic regions analysis Drosophila melanogaster
a
6.4.1.2 ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA catalytic regions analysis Saccharomyces cerevisiae
a
6.4.1.2 ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA catalytic regions analysis Caenorhabditis elegans
a
6.4.1.2 ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA catalytic regions analysis Caenorhabditis briggsae
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.4.1.2 adipose tissue
-
 Ovis aries
-
6.4.1.2 adipose tissue isozyme Acc1 Homo sapiens
-
6.4.1.2 brain
-
 Ovis aries
-
6.4.1.2 brain
-
 Mus musculus
-
6.4.1.2 brown adipose tissue isozyme Acc2 Rattus norvegicus
-
6.4.1.2 heart
-
 Ovis aries
-
6.4.1.2 heart isozyme Acc2 Homo sapiens
-
6.4.1.2 liver
-
 Gallus gallus
-
6.4.1.2 liver
-
 Rattus norvegicus
-
6.4.1.2 liver isozyme Acc1 Homo sapiens
-
6.4.1.2 lung
-
 Ovis aries
-
6.4.1.2 mammary gland
-
 Ovis aries
-
6.4.1.2 mammary gland
-
 Rattus norvegicus
-
6.4.1.2 mammary gland
-
 Mus musculus
-
6.4.1.2 mammary gland lactating, isozyme Acc1 Homo sapiens
-
6.4.1.2 additional information tissue-specific expression of isozymes Ovis aries
-
6.4.1.2 additional information tissue-specific expression of isozymes Homo sapiens
-
6.4.1.2 additional information tissue-specific expression of isozymes Rattus norvegicus
-
6.4.1.2 additional information tissue-specific expression of isozymes Mus musculus
-
6.4.1.2 muscle
-
 Ovis aries
-
6.4.1.2 skeletal muscle isozyme Acc2 Homo sapiens
-
6.4.1.2 spleen
-
 Ovis aries
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.4.1.2 ATP + acetyl-CoA + HCO3-
-
 Escherichia coli ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3-
-
 Saccharomyces cerevisiae ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3-
-
 Ciona intestinalis ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3-
-
 Danio rerio ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3-
-
 Takifugu rubripes ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- first committed step in fatty acid biosynthesis, hormonal, nutrient, and tissue-specific regulation of ACC genes, regulation of isozyme activity, overview Ovis aries ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- first committed step in fatty acid biosynthesis, hormonal, nutrient, and tissue-specific regulation of ACC genes, regulation of isozyme activity, overview Homo sapiens ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- first committed step in fatty acid biosynthesis, hormonal, nutrient, and tissue-specific regulation of ACC genes, regulation of isozyme activity, overview Rattus norvegicus ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- first committed step in fatty acid biosynthesis, hormonal, nutrient, and tissue-specific regulation of ACC genes, regulation of isozyme activity, overview Mus musculus ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- hormonal, nutrient, and tissue-specific regulation of ACC genes, overview Gallus gallus ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- regulation of isozyme expression and activity Caenorhabditis elegans ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- regulation of isozyme expression and activity, overview Drosophila melanogaster ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- regulation of isozyme expression and activity, overview Caenorhabditis briggsae ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase Gallus gallus ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase Drosophila melanogaster ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase Escherichia coli ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase Saccharomyces cerevisiae ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase Ovis aries ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase Caenorhabditis elegans ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase Ciona intestinalis ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase Danio rerio ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase Caenorhabditis briggsae ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase Takifugu rubripes ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase Homo sapiens ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase Rattus norvegicus ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase Mus musculus ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- regulation of isozyme expression and activity Caenorhabditis elegans W09B6 ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase Caenorhabditis elegans W09B6 ADP + malonyl-CoA + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
6.4.1.2 monomer 1 * 265000, isozyme Acc1 Homo sapiens
6.4.1.2 monomer 1 * 265000-270000, isozyme Acc1 Rattus norvegicus
6.4.1.2 monomer 1 * 265000-270000, isozyme Acc1 Mus musculus
6.4.1.2 monomer 1 * 280000, isozyme Acc2 Homo sapiens
6.4.1.2 More domain structure and organization of the isozyme, evolution and functional domains, overview Rattus norvegicus
6.4.1.2 More domain structure and organization, evolution and functional domains, overview Homo sapiens
6.4.1.2 More domain structure and organization, evolution and functional domains, overview Mus musculus
6.4.1.2 More domain structure, evolution and functional domains, overview Escherichia coli
6.4.1.2 More domain structure, evolution and functional domains, overview Saccharomyces cerevisiae

Synonyms

EC Number Synonyms Comment Organism
6.4.1.2 ACC
-
 Gallus gallus
6.4.1.2 ACC
-
 Drosophila melanogaster
6.4.1.2 ACC
-
 Escherichia coli
6.4.1.2 ACC
-
 Saccharomyces cerevisiae
6.4.1.2 ACC
-
 Ovis aries
6.4.1.2 ACC
-
 Caenorhabditis elegans
6.4.1.2 ACC
-
 Ciona intestinalis
6.4.1.2 ACC
-
 Danio rerio
6.4.1.2 ACC
-
 Caenorhabditis briggsae
6.4.1.2 ACC
-
 Takifugu rubripes
6.4.1.2 ACC
-
 Homo sapiens
6.4.1.2 ACC
-
 Rattus norvegicus
6.4.1.2 ACC
-
 Mus musculus
6.4.1.2 More the enzyme belongs to the family of biotin-dependent carboxylases Gallus gallus
6.4.1.2 More the enzyme belongs to the family of biotin-dependent carboxylases Drosophila melanogaster
6.4.1.2 More the enzyme belongs to the family of biotin-dependent carboxylases Escherichia coli
6.4.1.2 More the enzyme belongs to the family of biotin-dependent carboxylases Saccharomyces cerevisiae
6.4.1.2 More the enzyme belongs to the family of biotin-dependent carboxylases Ovis aries
6.4.1.2 More the enzyme belongs to the family of biotin-dependent carboxylases Caenorhabditis elegans
6.4.1.2 More the enzyme belongs to the family of biotin-dependent carboxylases Ciona intestinalis
6.4.1.2 More the enzyme belongs to the family of biotin-dependent carboxylases Danio rerio
6.4.1.2 More the enzyme belongs to the family of biotin-dependent carboxylases Caenorhabditis briggsae
6.4.1.2 More the enzyme belongs to the family of biotin-dependent carboxylases Takifugu rubripes
6.4.1.2 More the enzyme belongs to the family of biotin-dependent carboxylases Homo sapiens
6.4.1.2 More the enzyme belongs to the family of biotin-dependent carboxylases Rattus norvegicus
6.4.1.2 More the enzyme belongs to the family of biotin-dependent carboxylases Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
6.4.1.2 ATP
-
 Gallus gallus
6.4.1.2 ATP
-
 Drosophila melanogaster
6.4.1.2 ATP
-
 Escherichia coli
6.4.1.2 ATP
-
 Saccharomyces cerevisiae
6.4.1.2 ATP
-
 Ovis aries
6.4.1.2 ATP
-
 Caenorhabditis elegans
6.4.1.2 ATP
-
 Ciona intestinalis
6.4.1.2 ATP
-
 Danio rerio
6.4.1.2 ATP
-
 Caenorhabditis briggsae
6.4.1.2 ATP
-
 Takifugu rubripes
6.4.1.2 ATP
-
 Homo sapiens
6.4.1.2 ATP
-
 Rattus norvegicus
6.4.1.2 ATP
-
 Mus musculus
6.4.1.2 biotin
-
 Gallus gallus
6.4.1.2 biotin
-
 Drosophila melanogaster
6.4.1.2 biotin
-
 Escherichia coli
6.4.1.2 biotin
-
 Saccharomyces cerevisiae
6.4.1.2 biotin
-
 Ovis aries
6.4.1.2 biotin
-
 Caenorhabditis elegans
6.4.1.2 biotin
-
 Ciona intestinalis
6.4.1.2 biotin
-
 Danio rerio
6.4.1.2 biotin
-
 Caenorhabditis briggsae
6.4.1.2 biotin
-
 Takifugu rubripes
6.4.1.2 biotin
-
 Homo sapiens
6.4.1.2 biotin
-
 Rattus norvegicus
6.4.1.2 biotin
-
 Mus musculus